Magnetic chitosan medicine-carried nano particles and preparation method thereof

Abstract

The invention relates to a magnetic chitosan drug-loaded nanoparticle and its preparation method. Magnetic chitosan drug-loaded nanoparticle is spheroidal particle with particle diameter of 70-130nm and 5-flurouracil as active component. The preparation method comprises adopting acetic acid aqueous solution containing chitosan, gamma -Fe2O3nanoparticle and 5-flurouracil as water phase and liquid paraffin containing surfactant Span 80 as oil phase, mixing water phase and oil phase to obtain micro emulsion, washing with sodium citrate as cross-linking agent, and drying to obtain magnetic chitosan drug-loaded nanoparticle with entrapment efficiency of 40-50%, and drug loading dosage of particle of 15-25%.The inventive magnetic drug-loaded nanoparticle has obvious effects in promoting apoptosis of tumor cell, nano-graded particle diameter, good dispersity, no coacervation, and sustained release effect.

Description

technical field

[0001] The invention relates to the field of biomedical drug carriers, in particular to chitosan drug-loaded particles, in particular to magnetic chitosan drug-loaded nanoparticles. technical background

[0002] Chitosan is the product of deacetylation of chitin. It is an aminopolysaccharide with many unique physical, chemical properties and biological functions. Chitosan has good bioadhesive properties and biodegradability (Jiang Tingda. Chitosan. Beijing: Chemical Industry Press 2001: 1~32), which can enhance penetration and enzyme inhibition, so it was developed into The delivery carrier of biomacromolecular drugs to increase the effective concentration of drugs in the body and improve the curative effect. Compared with other types of polymer drug carriers, chitosan is not only rich in raw materials, but also has the advantages of low cost, biodegradability, good biocompatibility and bioaffinity, non-toxic, and easy chemical modification. It also has th...

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