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Intravenous medicine carrier material and its prepn process

A carrier material, intravenous drug technology, applied in the direction of non-active components of polymer compounds, etc., can solve problems such as limited application scope, and achieve the effects of easy to master, standardized equipment, and widely available sources.

Inactive Publication Date: 2007-12-19
李潮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its safety is still being studied, the scope of application is limited

Method used

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  • Intravenous medicine carrier material and its prepn process

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Embodiment 1

[0055] The intravenous drug carrier material of this embodiment is made of commercially available gelatin (Wenzhou Huabao Gelatin Co., Ltd.) as the base material.

[0056] Its preparation method is:

[0057] 1) gelatin is formulated into an aqueous solution according to 3% by weight;

[0058] 2) According to the weight ratio of gelatin and proteolytic enzyme is 100:1, add neutral protease into gelatin solution, and degrade at 50° C. for 60 min;

[0059] 3) According to the weight ratio of gelatin and cross-linking agent of 100:2, the glutaraldehyde aqueous solution was added to the gelatin degradation solution, and the cross-linking reaction was carried out at 25° C. for 20 h;

[0060] 4) The cross-linking reaction product is filtered and dried at 45°C for 20 hours to form a material.

[0061] The material prepared by the above method was mixed with urokinase to prepare a solution as the injection of the test group, and the solution prepared with simple urokinase was used as...

Embodiment 2

[0064] The method and equipment are basically the same as in Example 1, except that the gelatin in this example is formulated into an aqueous solution at 5% by weight; the crosslinking agent is a carbodiimide solution, and the crosslinking reaction is carried out at 5° C. for 12 hours. The measurement results of dynamic fibrinolysis rate are shown in curve 1 and curve 2 of Fig. 2 .

[0065] Figure 2 dynamic fibrinolysis rate

[0066] Curve 1 is the dynamic fibrinolysis rate of simple urokinase.

[0067] Curve 2 is the dynamic fibrinolysis rate of carrier-urokinase complex.

[0068] It can be seen from the figure that the intravenous drug carrier material of this embodiment has a good controlled release effect.

Embodiment 3

[0070] The method and equipment are basically the same as in Example 1, except that the gelatin in this example is formulated into an aqueous solution at 5% by weight; the crosslinking agent is a carbodiimide solution, and the crosslinking reaction is carried out at 15° C. for 18 hours. The measurement results of dynamic fibrinolysis rate are shown in curve 1 and curve 2 of Fig. 3 .

[0071] Figure 3 dynamic fibrinolysis rate

[0072] Curve 1 is the dynamic fibrinolysis rate of simple urokinase.

[0073] Curve 2 is the dynamic fibrinolysis rate of carrier-urokinase complex.

[0074] It can be seen from the figure that the intravenous drug carrier material of this embodiment has a good controlled release effect.

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Abstract

The present invention relates to intravenous medicine carrier material and its preparation process. The intravenous medicine carrier material is medicine release controlling material to avoid the fast removing of medicine from blood, and has itself no pharmacological effect. It is prepared with gelatin as base material, and through degrading gelatin in enzyme solution, cross-linking with cross-linking agent, purifying and drying. It has intravenous medicine release controlling effect, no toxicity, and other advantages.

Description

(1) Technical field [0001] The invention relates to a drug auxiliary material, which belongs to a drug carrier material which has no pharmacological effect and can slow down the rapid removal of protein drugs from blood and a manufacturing method thereof. (2) Technical background [0002] Some intravenous injection drugs have positive therapeutic effects, but due to the rapid rise and fall of the blood concentration of the drug after administration, the drug is maintained at the therapeutic concentration level for a short time, and the therapeutic effect is limited; at the same time, the side effects caused by the increase of the blood concentration The risk is increased by this. The kinetic characteristics of this class of drugs clearly hinder their clinical application. [0003] In order to reduce the risk caused by excessive drug blood concentration, the main preventive measure in clinical treatment is to control the dosage, but the price is to reduce the therapeutic eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42
Inventor 李潮
Owner 李潮
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