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Propofol medicinal composition for injection
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A kind of technology of propofol and composition, which is applied in the field of propofol pharmaceutical composition for injection, and achieves the effects of reducing market risk, the method is simple and easy, and not easy to decompose
Inactive Publication Date: 2012-12-19
TIANJIN SONGRUI MEDICAL TECH
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[0016] Propofol injection can also be used after dilution, but it can only be diluted with 5% glucose injection and stored in PVC infusion bag or infusion bottle
Method used
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Embodiment 1
[0058] Every 1000 described propofol pharmaceutical compositions for injection, its formula consists of:
[0059]
[0060] Including the following steps:
[0061] 1) Put the prescribed amount of soybean oil and medium-chain oil in the preparation container, mix evenly, and when heated to 55±5°C, add the prescribed amount of propofol, dissolve completely, and keep warm;
[0062] 2) Add the prescribed amount of glycerin, soybean lecithin, and poloxamer 188 into the prescribed amount of water, mix well, heat to 55±5°C, and keep warm;
[0063] 3) Add 2) to 1), and in a high-speed homogenizer, use 10000r / min and homogenize for 10 minutes to make colostrum.
[0071] Every 1000 described propofol pharmaceutical compositions for injection, its formula consists of:
[0072]
[0073] Preparation steps are the same as in Example 1.
Embodiment 3
[0075] Every 1000 described propofol pharmaceutical compositions for injection, its formula consists of:
[0076]
[0077] Preparation steps are the same as in Example 1.
[0078] The present invention also provides following test example, to illustrate the screening of process condition of the present invention:
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Abstract
The invention discloses a propofol medicinal composition for injection, which consists of propofol used as a raw material and soybean lecithin, poloxamer 188, soybean oil, medium chain oil, glycerol, oleic acid and water which are used as auxiliary materials. The propofol medicinal composition for injection has high stability and has more obvious advantages of improving the yield of a product, reducing the cost, implementing the industrialization and further clinically applying the propofol medicinal composition.
Description
technical field [0001] The invention relates to medicines in the field of medicine, in particular to a pharmaceutical composition of propofol for injection. Background technique [0002] Propofol, whose chemical name is 2,6-diisopropylphenol, is a new type of rapid and short-acting intravenous anesthetic commonly used clinically for induction of anesthesia, maintenance of anesthesia, and sedation of critically illICU patients. It has the advantages of fast onset of anesthesia induction, rapid recovery and complete functional recovery, and low incidence of postoperative nausea and vomiting. [0003] English name: propofol; [0004] Chemical name: 2,6-diisopropylphenol; [0005] Molecular formula: C 12 h 18 O; [0006] Molecular weight: 178.3; [0007] Indications: Inducer of general intravenous anesthesia, component of "total intravenous anesthesia" or adjunct to anesthesia. [0008] Dosage: The use of propofol usually requires the use of painkillers. Propofol can be...
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