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Method for preparing compound milettia reticulata particles

A technology of Glycyrrhiza chinensis and Dianjixueteng, which is applied in the field of preparation of compound Phyllostachys chinensis granules, can solve the problems of hard texture, low quality standard level, poor controllability and the like

Inactive Publication Date: 2008-02-06
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation has definite curative effect and a long history of application, but due to weak basic research, the current dosage form is backward, the quality standard level is low, and the controllability is poor
[0003] The finished product of compound Caulis Spatholobus paste in the prior art has a hard texture, and it needs to be mixed with half and half of wine and water, which is very inconvenient, and the total amount of auxiliary materials glutinous rice and caramel exceeds 70%. When taking it, the dosage of the medicine is increased.
Due to weak basic research, the 2005 edition of "Chinese Pharmacopoeia" only stipulates the properties of the preparation and the color reaction of coumarin and phenolic compounds under the item of compound Jixueteng ointment, which has poor specificity and lacks the characteristic identification and indicators of the medicinal flavors in the prescription. As for the content determination method of the ingredients, there is no report on the quality control of compound Jixueteng ointment in the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take Spathiphyllum yunnanensis, add water and decoct three times, the first time 6 times the amount of water for 4 hours, the second time 4 times the amount of water for 3 hours, the third time 4 times the amount of water for 2 hours, filter, the filtrate is concentrated to 1.28g / ml, 60 Vacuum-dried at ℃, crushed, passed through a No. 6 sieve, and set aside; Chuan Achyranthes bidentata, Dipsacus, safflower, and black beans were decocted three times, each time with 4 times the amount of water for 2 hours, combined decoction, filtered, and the filtrate was concentrated to 0.73g / ml, add Spatholobus Spatholobus paste powder, mix thoroughly, dry in vacuum at 60°C, pulverize, and pass through a No. 5 sieve. The obtained dry paste powder is uniformly mixed with soluble starch and xylitol powder in a ratio of 4:5:1.8, sprayed with 50% ethanol (amount of 30%) to make a soft material, granulated through a 12-mesh sieve, and dried at 60°C. Whole the granules and pack them separat...

Embodiment 2

[0019] Take Spathiphyllum yunnanensis, add water and decoct three times, the first time 6 times the amount of water for 4 hours, the second time 4 times the amount of water for 3 hours, the third time 4 times the amount of water for 2 hours, filter, the filtrate is concentrated to 1.30g / ml, 60 Vacuum dry at ℃, pulverize, pass through a No. 6 sieve, and set aside; Add water to decoct Achyranthes bidentata, Dipsacus, safflower, and black beans three times, each time 4 times the amount of water for 2 hours, combine the decoction, filter, and concentrate the filtrate to 0.70g / ml, add Spatholobus Spatholobus paste powder, mix well, dry in vacuum at 60°C, crush, and pass through a No. 5 sieve. Evenly mix the obtained dry cream powder with powdered sugar and dextrin in a ratio of 2:1:1, spray 50% ethanol (25% dosage) to make soft materials, pass through a 12-mesh sieve to granulate, dry at 60°C, and granulate , sub-package to obtain the sugar-containing granules of the present inven...

Embodiment 3

[0021] Take Spathiphyllum yunnanensis, add water and decoct three times, the first time 6 times the amount of water for 4 hours, the second time 4 times the amount of water for 3 hours, the third time 4 times the amount of water for 2 hours, filter, the filtrate is concentrated to 1.30g / ml, 60 Vacuum-dried at ℃, crushed, passed through a No. 6 sieve, and set aside; Chuan Achyranthes bidentata, Dipsacus, safflower, and black beans were decocted three times, each time with 4 times the amount of water for 2 hours, combined the decoction, filtered, and the filtrate was concentrated to 0.73g / ml, add Spatholobus Spatholobus paste powder, mix well, dry in vacuum at 60°C, crush, and pass through a No. 5 sieve. The obtained dry cream powder is evenly mixed with dextrin and xylitol in a ratio of 2:1:0.5, sprayed with 50% ethanol (25%) to make a soft material, granulated through a 12-mesh sieve, dried at 60°C, and dried. granules, sub-packaged to obtain the sugar-free granules of the pr...

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PUM

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Abstract

The present invention belongs to the traditional Chinese medicine pharmacy field and relates to a preparation method and the quality control method of compound Caulis Spatholobi granules. The present invention overcomes the shortcomings of the prior art; a main active ingredient is biphenyl cyclooctene lignin which is mainly allotype Kadsura peltigera; the main active ingredient is used as an index ingredient of the quality control of the compound Caulis Spatholobi granules with measurement of HPLC determination method. The made-up granules have exact curative effect for treating blood deficiency, deadlimb, joint ache and menoxenia. Compared with the prior art, the present invention has the advantages of convenient administration, small dosage and strong quality controllability.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method and a quality control method of compound Jixueteng granules. Background technique [0002] Compound Caulis Spatholobus Ointment is a traditional Chinese medicine, which is recorded in "Chinese Pharmacopoeia" (2005 edition one). It is processed from Yunnan Caulis Spatholobus Ointment Powder, Achyranthes Radix Chuanxie, Dipsacus, Safflower and Black Bean, and has the function of nourishing blood. , promoting blood circulation, regulating menstruation, used for blood deficiency, numb hands and feet, joint pain and irregular menstruation. The preparation has a definite curative effect and a long history of application. However, due to weak basic research, the current dosage form is backward, the quality standard level is low, and the controllability is poor. [0003] The finished product of compound Caulis Spatholobus paste in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/486A61K9/16A61P29/00A61P19/02A61P15/00
Inventor 卢燕陈道峰
Owner FUDAN UNIV