External plaster containing flurbiprofen
一种氟比洛芬、贴剂的技术，应用在氟比洛芬的外用贴剂领域，能够解决皮肤刺激、糊状残留、粘合剂凝集力破坏等问题，达到制剂稳定化、抑制结晶析出、稳定经皮吸收性的效果
Active Publication Date: 2008-02-06
TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
However, the volatile 1-menthol volatilizes during storage, resulting in the possibility of crystallization of flurbiprofen as the main ingredient
[0009] In addition, in Patent Document 5 (Japanese Unexamined Patent Publication No. 7-309749), a rubber-based adhesive using lactate as a flurbiprofen dissolving agent is disclosed. When formulated, the solvent may leave a pasty residue on the skin, and may also be a cause of skin irritation
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1～4
[0046] Examples 1 to 4 / Comparative Examples 1 to 3
[0047] According to the above-mentioned manufacturing method, a patch based on the mixed prescription of Table 1 (Examples 1 to 4) and Table 2 (Comparative Examples 1 to 3) was obtained.
[0048] Table 1
[0049]
Make up
Example
1
2
3
4
SIS
25
15
12
10
Rosin resin
30
40
50
60
41
40
32
23
BHT
2
2
2
2
2
3
4
5
[0050] Table 2
[0051]
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The present invention provides a transdermal external patch, which is an external patch in which an adhesive layer is laminated on a support, wherein the adhesive layer contains styrene-isoprene-benzene as an essential component. An ethylene block copolymer (SIS), a tackifying resin, and a softener, and flurbiprofen as an active ingredient are mixed therein. The external patch containing flurbiprofen makes possible the long-term stable release of the flurbiprofen contained, and the preparation has high stability and very high drug release.
Description
Technical field [0001] The present invention relates to an adhesive containing styrene-isoprene-styrene block copolymer (SIS), tackifying resin and softener as essential components, mixed with flurbiprofen as an effective component Of topical patches. Background technique [0002] Flurbiprofen, one of the non-steroidal analgesic and anti-inflammatory agents (NSAIDs), is widely used as an agent for chronic articular rheumatism, osteoarthritis, shoulder arthritis, low back pain, tenosynovitis, muscle pain, etc. The administration method can be oral administration in dosage forms such as tablets and granules, and transdermal administration in dosage forms such as ointments and patches. [0003] In the case of oral administration preparations, there are side effects such as gastrointestinal disorders specific to NSAIDs, and the drug absorbed in the body is metabolized and decomposed by the liver at an early stage, resulting in the disadvantage of reduced efficacy. [0004] In contras...
Claims
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IPC IPC(8): A61K31/192A61K9/70A61K47/32A61K47/44A61P19/02A61P29/00
CPCA61K9/7076A61K9/7053A61K31/192A61P19/00A61P19/02A61P29/00A61K47/32A61K47/44A61K9/7023A61K2121/00A61K9/70
Inventor 山地正博菅原贵也
Owner TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD