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Preparations containing rebeprazole and sodium bicarbonate and method for preparing the same

A technology of rabeprazole and sodium bicarbonate, applied in the directions of medical preparations containing active ingredients, pill delivery, pharmaceutical formulations, etc., can solve problems such as no research report on combined use and the like

Active Publication Date: 2008-03-05
SHANGHAI SINE PHARMA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no research report on the combination of rabeprazole and sodium bicarbonate

Method used

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  • Preparations containing rebeprazole and sodium bicarbonate and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Preparation of capsules (100 capsules)

[0061] Rabeprazole 2g

[0062] Sodium bicarbonate 100g

[0063] Mannitol 35g

[0064] Croscarmellose Sodium 10g

[0065] Magnesium stearate 2g

[0066] Hydroxypropyl Methyl Cellulose 10g

[0067] Cellulose acetate phthalate 20g

[0068] Mix 2 g of rabeprazole with the above-mentioned weight of mannitol and croscarmellose sodium to obtain material 1.

[0069] Dissolve the cellulose acetate phthalate of the above weight in 50ml of ethanol to prepare an enteric coating solution.

[0070] The above-mentioned material 1 was placed in a Mini-Glatt one-step granulator (Glatt Company, Germany), and powder-coated with the enteric-coating solution prepared above to obtain an enteric-coated powder.

[0071] Mix the above-mentioned enteric-coated powder with 10 mg of rabeprazole and the above-mentioned weight of magnesium stearate evenly, and put the resulting mixture into hard capsules.

[0072] The hydroxypropyl methylcellulose of ...

Embodiment 2

[0074] Preparation of dry suspension

[0075] Rabeprazole 20mg

[0076] Sodium bicarbonate 1500mg

[0077] Mannitol 500mg

[0078] Xylitol 100mg

[0079] Xanthan Gum 20mg

[0080] Sucralose 120mg

[0081] Menthol 100mg

[0082] Mix 10 mg of rabeprazole and the above weight of mannitol uniformly to obtain material 1.

[0083] Dissolve the cellulose acetate phthalate of the above weight in 50ml of ethanol to prepare an enteric coating solution.

[0084] Material 1 was placed in a Mini-Glatt one-step granulator (Glatt Company, Germany), and powder-coated with the obtained enteric coating solution to obtain a coated powder.

[0085] The obtained coating powder is mixed with 10 mg of rabeprazole, sodium bicarbonate of the above weight, xylitol, xanthan gum, sucralose and menthol to obtain the final product.

Embodiment 3

[0087] Preparation of orally disintegrating tablets

[0088] Rabeprazole 20mg

[0089] Sodium bicarbonate 2000mg

[0090] Mannitol 400mg

[0091] Maltose 200mg

[0092] Aspartame 150mg

[0093] Magnesium Stearate 60mg

[0094] Orange Flavor 600mg

[0095] Cellulose acetate phthalate 200mg

[0096] Mix 10 mg of rabeprazole and the above weight of mannitol uniformly to obtain material 1.

[0097] Dissolve the cellulose acetate phthalate of the above weight in 50ml of ethanol to prepare an enteric coating solution.

[0098] Material 1 was placed in a Mini-Glatt one-step granulator (Glatt, Germany), and powder-coated with the enteric coating solution prepared above to obtain a coated powder.

[0099] Mix the above-mentioned coating powder with 10 mg of rabeprazole, the above-mentioned weight of sodium bicarbonate, maltose, aspartame, orange essence, and magnesium stearate evenly, and directly compress into tablets to obtain the final product.

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Abstract

The present invention provides one kind of medicine composition comprising rabeprazole in 10-80 weight portions and sodium bicarbonate in 100-5000 weight portions. The medicine composition with both quickly released medicine and slowly released medicine is superior to enteric preparation, and has short peak reaching time and medicine acting time as long as 12-20 hr.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating peptic ulcer, in particular to a pharmaceutical composition containing rabeprazole and sodium bicarbonate. Background technique [0002] Peptic ulcer is a global frequently-occurring disease. With the aging of society, the incidence of peptic ulcer in the elderly is increasing. According to statistics, the incidence rate of gastric ulcer over the age of 65 is 5.2%, and it increases to 8.5% over the age of 70, and because of its atypical clinical symptoms, it is easy to be ignored. The health and quality of life of elderly patients is of paramount importance. [0003] At present, the drugs for the treatment of peptic ulcer disease can be divided into histamine H2 receptor antagonists, proton pump inhibitors, antacids and gastric mucosal protective agents. [0004] Proton pump inhibitors (Proton Pump Inhibitors, PPIs) have opened up a new way to treat peptic ulcer. Proton pump inhibit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61K33/10A61K9/00A61K9/48A61K9/20A61P1/04
Inventor 高原陈彬华王燕夏凌云曾亚琳
Owner SHANGHAI SINE PHARMA LAB
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