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Medicament for preventing and treating alzheimer's disease and caducity

A technology of Alzheimer's disease and drugs, applied in the field of medicine, to improve the energy metabolism of brain cells, with great theoretical significance, prevention and treatment of AD and aging effects

Active Publication Date: 2008-03-05
SHANGHAI RIXIN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no research reports on the prevention and treatment of AD and aging by modulating blood thiamine concentration or / and thiamine-related protease activity at home and abroad.

Method used

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  • Medicament for preventing and treating alzheimer's disease and caducity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Animal experiment

[0018] 1) preparation of different dosage forms of benfotiamine

[0019] According to conventional methods, respectively prepare benfotiamine tablet, powder, powder injection, rectal suppository, skin patch (transdermal administration), wherein use lipoic acid, hydrochloric acid, Lactic acid, carbonic acid, phosphoric acid or phosphate buffer solution to prepare benfotiamine aqueous injection and spray;

[0020] 2) Clinical application experiments of different dosage forms of benfotiamine,

[0021] Apply different dosage forms of benfotiamine, through different routes of oral (including) oral administration, intramuscular injection, intraperitoneal injection, intravenous injection, spray administration, rectal administration or transdermal administration, using 1 mg-1000 mg per day to prevent or to treat Alzheimer's disease or aging;

[0022] 3) Animal experiment curative effect observation,

[0023] By oral or intraperitoneal inject...

Embodiment 2

[0027] 1, conventional method prepares benfotiamine tablet;

[0028] 2. By oral administration, give 6-month-old transgenic AD model mice or 12-month-old wild Kunming mice a daily dose of 1 mg-1000 mg of benfotiamine for 6 consecutive months;

[0029] 3. The mice in the benfotiamine treatment group can significantly improve the cognitive function and prolong the average life expectancy of the mice. The results prove that benfotiamine can prevent and treat Alzheimer's disease and aging.

Embodiment 3

[0031] 1. Preparation of benfotiamine aqueous injection by conventional method;

[0032] 2. Through intraperitoneal administration, give 6-month-old transgenic AD model mice or 12-month-old wild Kunming mice a daily dose of 1 mg-1000 mg of benfotiamine for 6 consecutive months;

[0033] 3. The mice in the benfotiamine treatment group can significantly improve the cognitive function and prolong the average life expectancy of the mice. The results prove that benfotiamine can prevent and treat Alzheimer's disease and aging.

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PUM

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine for preventing and treating Alzheimer disease or senility and its preparation process. The medicine of the present invention consists of benfotiamine and / or lipoic acid, carnitine, zinc sulfate, coenzyme Q10, vitamin B6 and folic acid and / or mecobalamin. Benfotiamine has molecular formula of C19H23N4O6PS and molecular weight of 466.45. Animal experiment shows that the medicine of the present invention has the effects of improving mitochondrion function of mouse, eliminating in vivo free radical, antagonizing oxidation injury, improving cognition capacity and prolonging life. The medicine for preventing and treating Alzheimer disease or senility possesses broad clinical application foreground.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a medicine for preventing and treating Alzheimer's disease or aging and a preparation method thereof. Background technique [0002] Alzheimer's disease (AD) is a chronic, age-related brain degenerative disease, mainly manifested by impairment of brain cognitive functions such as learning and memory. According to reports, in European and American countries, 4%-12% of the elderly over the age of 60 develop dementia, and more than half of them are AD. Recent survey results show that the incidence of dementia in my country is close to that of European and American countries. There are more than 5 million elderly patients with dementia, of which AD accounts for 2 / 3. With the acceleration of population aging, the incidence and prevalence of AD will further increase, which will bring heavy mental and economic burdens to patients, families and society. [0003] At present, the exact pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61P25/28A61P39/06A61K31/122A61K31/205A61K31/4415A61K31/505A61K31/519A61K31/714
Inventor 钟春玖费国强
Owner SHANGHAI RIXIN BIOTECHNOLOGY CO LTD
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