Dripping pill for treating digestive ulcer and medicine composition containing the same

A technology for digestive tract ulcers and compositions, applied in the field of pharmaceutical preparations for the treatment of digestive tract ulcers, can solve problems such as difficulty in completely reaching the colon, inconvenient use of enemas, and difficult acceptance by patients, so as to achieve labor protection and environmental protection, and improve Bioavailability, portable effect

Inactive Publication Date: 2008-03-19
杨明 +1
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, because the main components of Periplaneta americana extract are easily destroyed by gastrointestinal fluids, enemas are used to treat UC. However, enema drugs are difficult to fully reach the colon and are unevenly d

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 medicine dropping pill of the present invention

[0035] 1. Buy the commercially available Periplaneta americana extract and keep it for later use. The semi-finished products used in this study were provided by Sichuan Panxi Cannonda Pharmaceutical Co., Ltd. The standard number is WS 3 -B-3674-2002(Z).

[0036] Two, the formula of drop pill preparation

[0037]The matrix used in this example is polyethylene glycol 6000, and the ratio of the extract to the matrix is ​​1:4.

[0038] 3. Preparation process of dropping pills

[0039] Step 1: Take an appropriate amount of ethanol to dissolve the extract according to parts by weight, mix the extract and the matrix evenly at a ratio of 1:4, place in a heating container and heat while stirring until melting;

[0040] Step 2: Use a special pilling machine (such as the DW-1 pilling machine of Jiangsu Taizhou Pharmaceutical Machinery No. The temperature of the condensation column is controlled...

Embodiment 2

[0094] Embodiment 2 The preparation of the dripping pill of the present invention

[0095] Take the ethanol extract of Periplaneta americana, add the same amount of 70% ethanol as the extract, dissolve after heating in a water bath (70° C.), and stir evenly. Take PEG6000 of 4 times the amount of the extract as the drop pill matrix, add it to the extract, use liquid paraffin as the condensing agent, and make drops according to the following conditions: the temperature of the feed liquid is 75°C, the dropping speed is 40 drops / min, and the drop distance is 6cm. After the dropping pills are formed, the condensing agent is removed and dried in a desiccator for 12 hours.

Embodiment 3

[0096] The preparation of embodiment 3 coating drop pills of the present invention

[0097]Take the ethanol extract of Periplaneta americana, heat until the fat dissolves, and mix well. Add 3 times the amount of glyceryl monostearate of the extract, heat and melt, stir evenly, use methyl silicone oil as a condensing agent, and make drops according to the following conditions: material liquid holding temperature 80°C, dropping speed 60 drops / min, drop The distance is 5cm, and the condensation temperature is 10℃±1℃. After the drop pills are formed, the condensing agent is removed and dried in a desiccator.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Wavelengthaaaaaaaaaa
Login to view more

Abstract

A dropping pill for remedying the alimentary tract canker considers extract of American periplaneta ethanol as the active component and is the dropping pill which is prepared by being mixed with a matrix, wherein the total weight of aminophenol which is contained in each dropping pill can not be less than 0.35 percent. The invention also provides the preparation method of the dropping pill and an intestines soluble preparation which contains the dropping pill. The dropping pill of the invention can meet the requirement of large production and at the same time can be prepared as an oral colon positioning preparation, which ensures that the drug can successfully arrive at the position of the colon through the alimentary tract after being orally taken to be released, thus the drug concentration at the position of the colon is improved; the pain of the patient is relieved, and the conformance performance is improved.

Description

technical field [0001] The invention relates to a pharmaceutical preparation for treating peptic ulcer, in particular to a drop pill prepared by using ethanol extract of Periplaneta americana as an active ingredient, and belongs to the field of medicine. Background technique [0002] Periplaneta americana (Linnaeus) is an animal of the genus Periplaneta in the cockroach family. Its main components are proteins, polypeptides and 18 kinds of amino groups and components. Promote angiogenesis, promote the shedding of necrotic tissue, promote the proliferation of granulation tissue and epithelial growth and so on. Periplaneta americana extract is used to treat gastric ulcer and duodenal ulcer orally, and enema administration is used to treat ulcerative colitis. The ethanol extract of Periplaneta americana is an existing commercially available product, which complies with the provisions of the State Food and Drug Administration Standard Identification Item, and the standard numbe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K35/64A61K9/20A61K9/48A61P1/04A61J3/06
Inventor 杨明李小芳黄毅
Owner 杨明
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap