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Method for producing radiotracer

A technology of radioactive tracers and production methods, which is applied in the direction of radioactive preparations in vivo, devices for transforming chemical elements by radiation, and pharmaceutical formulations, etc., which can solve the problems of repeated start-up and use, poor flexibility of use, and inability to produce online, etc., to achieve convenience in clinical practice application, improve overall performance, and reduce the effect of production operations

Inactive Publication Date: 2008-04-02
王黎
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The purpose of the present invention is to overcome the shortcomings of the existing method for producing radioactive tracers in cyclotrons and provide a radioactive tracer with multi-purpose, randomized on-line production, highly integrated, small volume, stable method and low-cost production. The production method of the tracer, which solves the problems of low efficiency, inability to produce on-line production, large equipment volume, complex design, inability to start and use repeatedly in a short period of time, poor use flexibility and high maintenance costs in the existing cyclotron production method for radioactive tracers. shortcoming

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  • Method for producing radiotracer
  • Method for producing radiotracer
  • Method for producing radiotracer

Examples

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Embodiment 1

[0044] Example 1: Method of radiotracer production without particle beam acceleration process:

[0045] The production method of the radioactive tracer in this embodiment is to use a high-power laser and the primary target to generate a particle beam; after the particle beam is focused, it reacts with the radionuclide target material to produce a radionuclide after a nuclear reaction; the radionuclide is processed Or synthesized and made into radioactive tracers for human imaging. The specific steps are as follows:

[0046] 1] Generating laser beams: high-power lasers generate high-energy, high-density laser beams, and the power on the laser spot needs to reach 10 15 W / cm 2 above.

[0047] 2] Generation of particle beams: high-energy particle beams are used to interact with primary targets to complete 180 (p, n) 18 F nuclear reaction produces particle beams, and the energy of the particle beams needs to be greater than 1.5 MeV; different primary targets are selected accord...

Embodiment 2

[0052] Example 2: Method of radiotracer production with particle beam acceleration process:

[0053] When large doses of radionuclides need to be produced, the focused particle beam can be re-accelerated; in this embodiment, the radioactive tracer production method is to use a high-power laser and a primary target to generate a particle beam; the particle beam is focused and After further acceleration, it reacts with the radionuclide target material and produces radionuclide after a nuclear reaction; the radionuclide is processed or synthesized to make a radioactive tracer for human imaging. Specific steps are as follows:

[0054] 1] Generating laser beams: high-power lasers generate high-energy, high-density laser beams, and the power on the laser spot needs to reach 10 15 W / cm 2 above.

[0055] 2] Generate particle beam: Generate particle beam: high-energy particle beam is used to interact with the primary target to complete 180 (p, n) 18 F nuclear reaction produces part...

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Abstract

The invention discloses a production method of radioactive tracer and includes the following steps: a high power laser is adopted to match with a primary target to generate particle beam; the particle beam completes nuclear reaction with the matter on a radioactive tracer target after focusing and accelerating so as to generate target radioactive tracer; finally, the target radioactive tracer is transmitted to a radioactive tracer synthesis system to synthesize radioactive tracer which is used in human body visualization. The method overcomes the disadvantages of the prior radioactive tracer production method through adopting cyclotron such as low efficiency, incapability of on-line production, big equipment volume, complex design, incapability of repeated starting up for use in a short time, poor flexibility in use and high maintenance cost; meanwhile, the invention has the advantages of instant on-line production of radioactive tracer, realization of desktop radioactive tracer production system, low shielding requirements of equipment, overall performance improvement of radioactive tracer production system and reduction in production and operating costs.

Description

technical field [0001] The invention relates to a method for producing radiotracers using high-power laser beams and radionuclide targets. Background technique [0002] Radiotracers are the basis and precursor of clinical molecular imaging. If there is no positron nuclide (positron nuclide), then PET, PET / CT, PET / MRI and other equipment cannot play their clinical role and value. The current clinical routine uses the medical cyclotron method to produce radionuclides, such as 15 O. 13 N. 11 C. 18 F. 124 I and 64 Cu et al. The medical cyclotron method (Cyclotron) first needs an ion source (ionicsource) to generate ions (generally using H 2 The method of ionizing into ions), and then the ion beam is accelerated in the cyclotron, and when the energy reaches the preset energy, the accelerated ion beam is extracted and the target material produced by the radionuclide undergoes a nuclear reaction to obtain all Positron radionuclides required. The obtained positron radioact...

Claims

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Application Information

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IPC IPC(8): G21G1/00A61K51/00
Inventor 王黎
Owner 王黎
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