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Establishing beagle dog myocardial infarction model using polythene foam plugging method

A technology of polyethylene foam and myocardial infarction, applied in the fields of application, medical science, surgery, etc., can solve the problems of increased animal mortality, inaccurate blockage of coronary arteries, long operation time, etc., achieve good experimental repeatability and improve success rate , the effect of easy survival

Inactive Publication Date: 2008-04-09
ZHEJIANG HOSPITAL
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Problems solved by technology

This method is inaccurate to block the coronary artery, the operation time is relatively long, and it is easy to increase the mortality of animals. [5]

Method used

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  • Establishing beagle dog myocardial infarction model using polythene foam plugging method
  • Establishing beagle dog myocardial infarction model using polythene foam plugging method
  • Establishing beagle dog myocardial infarction model using polythene foam plugging method

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Embodiment Construction

[0030] The method for establishing the myocardial infarction model by applying polyethylene foam plugging method comprises the steps:

[0031] 1) 30 Beagle dogs, half male and half male, weighing 10-13 kg, were provided by the Animal Experiment Center of Zhejiang University of Traditional Chinese Medicine. Dogs are fasted for 12-16 hours before operation, and water is deprived for 4-6 hours. 3% pentobarbital sodium 1-2ml / kg is used for general anesthesia by intraperitoneal injection. The route of anesthetic administration can also choose pentobarbital sodium intravenously. anaesthetization. Other types of anesthetic drugs may also be used. The main requirement is that the dog can tolerate and go through the operation safely and smoothly;

[0032] The experimental equipment used includes: C-arm X-ray machine: H5000, PHILIPS company; ECG monitoring instrument: polychannel physiological recording instrument of Prucka Engineering company; 76% diatrizoate glutamine diluted into 5...

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Abstract

The invention discloses a method for applying a polyethylene foam blocking method to establish a myocardial infarction model. The polyethylene foam blocking method is used to block the left coronary artery of a Beagle dog through a cardiac catheter technology, and the animal model of the chronic myocardial infarction is arranged. After 30 pieces of 10-12 Kg Beagle dog is fully narcotized through a common carotid artery, firstly, after the ischemia is pre-adapted, the polyethylene foam is used to drop in the 1 / 3 position of the distant end at the left front part through a conduit tube embolus, and then the myocardial infarction model is caused. The model manufacture of all dogs succeeds, one dog is dead due to the damage of a coronary pulse and the cardiac tamponade during the operation process, and two dogs are dead in the operation room due to tremor. Two dogs are dead due to occurring III degree room conduction block during the operation process. The model manufacture to other dogs succeeds. The instant survival rate of the operation reaches 83.3percent, the survival rate after operating within two weeks is 66.6 percent. The effect that a polyethylene foam embolus blocking method that can not transmit X ray is used to manufacture the myocardial infarction model is definite, the invention is close to the clinical pathology physiology process, the repeatability is good, the invention is safer compared with a traditional thoracotome buckling coronary artery, the invention can be taken as an experimental platform used for researching the myocardial ischemia.

Description

technical field [0001] The invention relates to a method for establishing a myocardial infarction model by using a polyethylene foam plugging method. Background technique [0002] Coronary heart disease has become the number one killer in the world. Therefore, the study of the pathogenesis of coronary heart disease has become a research hotspot. Acute myocardial infarction is a critical stage in the development of coronary heart disease. Therefore, how to establish a good and reproducible experimental animal model of acute myocardial infarction has become the basis and premise for the study of coronary heart disease. As a breed, Beagle dogs have the characteristics of fixed and excellent breeds and stable genetic performance. Generally, there is no hereditary neurological disease, and the reproducibility is good and stable in research work. And many characteristics of dogs are closer to people. Among the research results using dogs as experimental animals, only Beagle c...

Claims

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Application Information

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IPC IPC(8): A61B19/00A61B90/00
Inventor 沈法荣黄杼伟金红峰凌锋
Owner ZHEJIANG HOSPITAL
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