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A buccal pellicle for treating gingivitis and oral mucosa canker as well as its preparation method

A technology for oral mucosa and gingivitis, which is applied in the field of sustained-release liposome buccal film to achieve the effects of fast absorption, low price and high drug concentration

Inactive Publication Date: 2008-04-09
BEIJING UNION GENIUS PHARMA TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no relevant literature report on the therapeutic effect of high-ester catechin buccal film on gingivitis and oral mucosal ulcers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Dissolve 30 g of sodium alginate in 1000 ml of purified water to prepare 3% sodium alginate solution I; then add 5 g of high-ester catechin powder into solution I, and mix thoroughly so that the final concentration of high-ester catechin is 0.5 %, to obtain solution II; then use a syringe to add solution II dropwise to 1.0% CaCl 2 The solution was stirred for about 1 hour to obtain white spheres, which were taken out and washed with water until neutral, and then dried to obtain sustained-release liposomes of high-ester catechins. where CaCl 2 The ratio of the amount of the solution to the volume of the sodium alginate solution I is 4:1.

[0032] The formulation of the drug film is as follows: 5 g of high-ester catechin sustained-release liposome, with a final concentration of 50 g / L; 10 g of polyvinyl alcohol; and 2.0 g of glycerin. According to the above steps, the medicine film is made, cut, sterilized, packaged, and the product is obtained.

Embodiment 2

[0034] Dissolve 15 g of sodium alginate in 1000 ml of purified water to prepare 1.5% sodium alginate solution I; then add 50 g of high-ester catechin powder into solution I, and mix thoroughly so that the final concentration of high-ester catechin is 5 %, to obtain solution II; then use a syringe to add solution II dropwise to 2.0% CaCl 2 The solution was stirred for about 1 hour to obtain white spheres, which were taken out and washed with water until neutral, and then dried to obtain sustained-release liposomes of high-ester catechins. where CaCl 2 The ratio of the amount of the solution to the volume of the sodium alginate solution I is 1:1.

[0035] The formulation of the drug film is as follows: 1 g of high-ester catechin sustained-release liposome, with a final concentration of 10 g / L; 10 g of polyvinyl alcohol; and 2.5 g of glycerin. According to the above steps, the medicine film is made, cut, sterilized, packaged, and the product is obtained.

Embodiment 3

[0037] Dissolve 10 g of sodium alginate in 1000 ml of purified water to prepare 1% sodium alginate solution I; then add 20 g of high-ester catechin powder into solution I, and mix thoroughly so that the final concentration of high-ester catechin is 2 %, to obtain solution II; then use a syringe to add solution II dropwise to 3.0% CaCl 2 The solution was stirred for about 1 hour to obtain white spheres, which were taken out and washed with water until neutral, and then dried to obtain sustained-release liposomes of high-ester catechins. where CaCl 2 The ratio of the amount of the solution to the volume of the sodium alginate solution I is 1:2.

[0038] The formulation of the drug film is as follows: 10 g of high-ester catechin sustained-release liposome, with a final concentration of 100 g / L; 15 g of polyvinyl alcohol; and 3.0 g of glycerin. According to the above steps, the medicine film is made, cut, sterilized, packaged, and the product is obtained.

[0039] The present inv...

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PUM

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Abstract

The invention relates to slow release liposome mouth dissolving film agent for remedying gingivitis and oral mucosa helcosis and the preparation technology thereof. The invention belongs to the biologic medicine field, in particular relates to slow release liposome mouth film agent taking high-fat catechin as a main component. The preparation of the slow releasing liposome applies the package technology of sodium alginate and calcium salt conversion liposome. The product of the technology is used for remedying the gingivitis and the oral mucosa helcosis, the invention is simple, the curative effect is reliable, the price is cheap, and the invention is adaptive to the national situation.

Description

technical field [0001] The invention relates to the field of biomedicine, a slow-release liposome buccal agent for the treatment of gingivitis and oral mucosal ulcers and its preparation technology, in particular to a slow-release liposome whose main component is high-ester type catechin Plastid oral membrane agent. Background technique [0002] The incidence of oral diseases in the population is very high, and gingivitis and oral mucosal ulcers are common and frequently-occurring diseases in the Department of Stomatology. The inflammation of gingival tissue makes gingival hyperemia edema, discharge pus, hemorrhage and halitosis. Oral mucosal ulcers occur periodically and repeatedly, and can occur several times a year, or several times a month, and even new and old lesions appear alternately. Dental caries is a progressive lesion of dental hard tissue caused by multiple factors in the oral cavity. It is characterized by demineralization of inorganic matter and decompositio...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61K9/127A61K47/36A61K47/38A61P1/02
Inventor 李楠韩国柱张维英王爱平王童王英明李万芳
Owner BEIJING UNION GENIUS PHARMA TECH
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