Self-sterilized, antiseptic collagen preparations, their use and method for producing them

一种胶原蛋白、原蛋白的技术，应用在医药和/或者美容目的胶原蛋白制品,自消毒胶原蛋白制剂制备的制品领域，能够解决昂贵、费时等问题，达到制备成本增加的效果

Inactive Publication Date: 2008-04-16
LOHMANN & RAUSCHER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In addition, the above-mentioned disinfection methods are expensive and time-consuming

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1 liter of a 1% (w / w) aqueous collagen solution (pH 6.5) was thoroughly mixed with 20 ml of a 20% aqueous solution of poly(hexamethylenebiguanide) hydrochloride (Cosmocil(R) QC) at room temperature. After mixing, the viscosity of the formulation increased slightly due to the physical interaction between collagen and PHMB. The mixture thus prepared is cast into polystyrene, polyethylene or polypropylene moulds, deep cooled at -40° C. and dried under vacuum (lyophilization).

[0059] In order to test the antibacterial effect of the resulting collagen sponge, a standard test (agar diffusion test) was carried out on it. These agar diffusion tests were performed with Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans and showed that the antibacterial effect of the collagen sponge lasted for >120 hours .

Embodiment 2

[0061] At room temperature, 800 ml of the collagen / PHMB mixture of Example 1 and 200 ml of 1% (w / w) sodium alginate aqueous solution were thoroughly stirred. The prepared collagen preparations were cast into polystyrene, polyethylene or polypropylene molds, deep cooled at -40°C and dried under vacuum (lyophilization).

[0062] In order to test the antibacterial effect of the resulting collagen sponge, a standard test (agar diffusion test) was carried out on it. These agar diffusion tests were performed with Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans and showed that the antibacterial effect of the collagen sponge lasted for more than 120 hours.

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PUM

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Abstract

The present invention relates to a method for disinfecting collagen preparations, the preparation of self-sterilizing, antibacterial collagen preparations, and to its use in the preparation of collagen preparations, such as sponges, membranes or gels, in particular for medicinal and / or cosmetic purposes. glue), and to articles prepared from said self-sterilizing collagen preparation.

Description

technical field [0001] The present invention relates to a method for disinfecting collagen preparations and to the preparation of self-sterilizing, antibacterial collagen preparations, and to the preparation of collagen preparations, such as sponges, membranes or gels, in particular for medical and / or cosmetic purposes. glue), and to articles prepared from said self-sterilizing collagen preparation. Background technique [0002] Collagen is the most important fibrous component of skin, bones, tendons, cartilage and blood vessels. Collagen is a structural protein and is characterized by a particular amino acid composition. Thus, the glycine portion of the polypeptide chain amounts to roughly one-third, the proline portion is higher than in most proteins, and collagen is characterized by the presence of amino acids 4-hydroxyproline and 5-hydroxyproline rarely found in other proteins. Hydroxylysine. In its native form, collagen exists as a triple helix (triple helix) stabili...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/06
CPCC08L89/06C08L2666/26
Inventor 胡里安-科尔内留·阿卢佩伊马里于斯-托马斯·戈尔卡彼得·路得克里斯琴·勒雷尔赫尔穆特·鲁普赖特
Owner LOHMANN & RAUSCHER
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