Preparation for chemical composition of Shenmai injection and application in treating cardiovascular and cerebrovascular diseases thereof

Abstract

The invention discloses three compounds of hydroxide radical methyl ophiopogonanone B (hereinafter referred as 6), 2Belta-hydroxide radical methyl ophiopogonanone A (hereinafter referred as 7a) and 2Alpha- hydroxide radical methyl ophiopogonanone A (hereinafter referred as 7b) for SMI and the preparation method thereof. The invention also discloses a method for controlling the quality of the SMI so as to control the compound 6, 7a and 7b and active compound methyl ophiopogonanone B (hereinafter referred as 5), ophiopogonin A (hereinafter referred as 8) and ginsenoside Rb1 with a fixed quantity. A plurality of researches prove that the components can be the main active substances of caring cardiovascular disease through the SMI. As the invention is added with ophiopogon angiocarpy active ingredient as a quality control standard, the quality of the SMI product is more stable and reliable when compared with the traditional quality control art, thereby fundamentally solving the problem of being unbeneficial for the quality control of the ophiopogon part during the traditional SMI production process.

Description

Technical field [0001] The invention relates to a preparation method of a new compound and active chemical composition of a traditional Chinese medicine injection for the treatment of cardiovascular and cerebrovascular diseases, and its application in the treatment of cardiovascular diseases and in quality control. Background technique [0002] Shenmai Injection (also known as "Shenmai Injection", hereinafter referred to as "Shenmai Needle") is a derivative of the ancient prescription "Shengmai San", which is extracted and processed from two traditional Chinese medicinal materials, red ginseng and Ophiopogon japonicus. It is used to treat shock, coronary heart disease, viral myocarditis, chronic pulmonary heart disease, and neutropenia of deficiency of both qi and yin. It is a national protection product of traditional Chinese medicine and is a basic emergency medicine. Shenmai Needle has been clinically used for more than 20 years, but the active ingredients in it have not been ...

AI Technical Summary

Problems solved by technology

Shenmai needles have been clinically used for more than 20 years, but the active ingredients in them have not been very clear. The current quality standards for Shenmai needles only stipulate three ginsenosides Rb in ginseng (red ginseng) 1 , Rg 1 and Re content determination, but did not reflect the active ingredients of another medicinal material Radix Radix in the prescription at all, which is very unfavorable to the quality control of Radix Radix in the production of medicines, and thus to the quality control of Shenmai Injection. quite unfavorable

[0003] At the same time, there are a large number of traditional Chinese medicine preparations containing Ophiopogon japonicus in the market, such as Shengmai Capsules, Yixin Oral Liquid, Xintong Oral Liquid, etc., and there has been a lack of effective quality control methods for Ophiopogon japonicus for a long time. The quality control method is also a problem to be solved

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