Asepsis patch for postoperative wound pain relieving

A technology of patch and wound, applied in the field of patch, can solve the problems of organ tissue toxicity, high cost of pain relief pump, inconvenience of life, etc., and achieve the effect of slow release

Inactive Publication Date: 2008-07-09
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pain is an inevitable reaction of patients during surgical wound healing, which generally lasts for 3-7 days. The existing postoperative pain relief methods are mostly oral analgesic drugs or the use of pain relief pumps, although the above methods can relieve the pain of patients to a certain extent. Pain, however, after taking painkillers orally, the drugs are distributed throughout the body, and only a small part of the drugs reach the wound, which not only has poor pain relief effect, but also causes unnecessary toxicity to other organs and tissues
In addition, during the wound healing period, it is necessary to take oral painkillers several times a day to relieve the pain of the patient; the use of the pain pump is not only costly, but it will also bring a lot of inconvenience to the patient's life if the patient is kept using the pain pump for a few days after the operation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A sterile patch for postoperative wound pain relief, which is composed of an anti-adhesion layer, a drug storage layer and a backing layer. The drug storage layer is composed of a framework material of polyvinyl alcohol and microspheres carrying Lidocaine. Each square centimeter of the membrane contains 5 mg of lidoca.

[0013] Lidocaine-loaded microspheres are prepared by a conventional spray drying method. The drug-loaded microspheres prepared by using polylactic acid and lidocaine are uniformly mixed with the framework material polyvinyl alcohol, coated on the backing layer and then covered with an anti-adhesive layer. The preparation process is carried out under aseptic conditions.

[0014] Before use, peel off the anti-adhesive layer, stick the medicine storage layer with the backing layer directly on the wound after suture treatment, then peel off the backing layer, and finally wrap the wound with sterile gauze.

Embodiment 2

[0016] A sterile patch used for postoperative wound pain relief, which is composed of an anti-adhesion layer, a drug storage layer and a backing layer. The drug storage layer is composed of a framework material chitosan and microspheres loaded with tetracaine. Each square centimeter of the membrane contains 1 mg of Dinka.

[0017] The microspheres loaded with tetracaine are prepared by the emulsification-solvent volatilization method. Polylactic acid-glycolic acid and tetracaine are used to prepare drug-loaded microspheres, which are then uniformly mixed with chitosan as the framework material, and then coated on the backing layer and covered with an anti-adhesion layer. The preparation process is carried out under aseptic conditions.

Embodiment 3

[0019] A sterile patch for postoperative wound pain relief, which is composed of an anti-adhesion layer, a drug storage layer and a backing layer. The drug storage layer is composed of a skeleton material polyvinylpyrrolidone and procaine-loaded microspheres . Each square centimeter of the membrane contains 3 mg of proca.

[0020] Procaine-loaded microspheres are prepared by the emulsification-solvent evaporation method. Chitosan and procaine are used to prepare drug-loaded microspheres, which are then uniformly mixed with the framework material polyvinylpyrrolidone, coated on the backing layer and then covered with an anti-adhesive layer.

[0021] The preparation process is carried out under aseptic conditions.

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PUM

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Abstract

The present invention discloses aseptic sticking membrane agent used for postoperation wound acesodyne, which consists of an anti-sticking layer, a drug-storing layer and a back lining layer. The drug-storing layer consists of framework material and microsphere loaded with local anesthetic, and the framework material is macromolecular polymer with film forming ability. The aseptic sticking membrane agent used for the postoperation wound acesodyne of the present invention can realize the uniform, lasting and slow release of the drug to achieve the lasting acesodyne effect, because the local anesthetic is wrapped inside the microsphere by the micro spheroidization technology. The aseptic sticking membrane agent used for the postoperation wound acesodyne of the present invention is used for the postoperation wound acesodyne, which can ensure that a patient does not have obvious painful feeling during the wound healing period.

Description

Technical field [0001] The invention relates to a patch, in particular to a patch for postoperative wound pain relief. Background technique [0002] Pain is an inevitable reaction of patients during surgical wound healing. It usually lasts for 3-7 days. The existing postoperative pain relief methods are mostly oral pain medications or the use of analgesic pumps, although the above methods relieve the patients to a certain extent. Pain, however, after oral administration of analgesics, the drugs are distributed throughout the body, and only a small part of the drugs reach the wound, which not only has a poor analgesic effect, but also causes unnecessary toxicity to other organs and tissues. In addition, during the wound healing period, it is necessary to take orally analgesics several times a day to relieve the pain of the patient; the use of an analgesic pump is not only costly, but it will also bring a lot of inconvenience to the life of the patient to use the analgesic pump for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/167A61K31/245A61K47/38A61K47/36A61K47/34A61P23/02
Inventor 魏振平周倩
Owner TIANJIN UNIV
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