Amlodipine controlled release patch and preparing method thereof

Abstract

The invention belongs to medical technique field and discloses an amlodipine controlled-release patch and a preparation method. The invention comprises a backing layer, a drug reservoir and an anti-sticking layer. The drug reservoir consists of amlodipine which is the main medicine materials, pressure sensitive adhesive and composite and percutaneous absorption enhancer; wherein, the dosage of amlodipine accounts for 0.5 to 45 wt percent of the weight of drug reservoir, the dosage of pressure sensitive adhesive accounts for 10 to 90 wt percent of the weight of drug reservoir and the dosage of the composite and percutaneous absorption enhancer accounts for 1 to 45 wt percent of the weight of drug reservoir. The invention also can be added with plasticizer, tackifier and chemical inhibitor, etc. an amlodipine controlled-release patch is a novel drug delivery system which can avoid the gastrointestinal stimulation of oral dosage and release drug slowly to relieve the side effects of the drug, and releases drug continuously for 72 hours, thereby having persistent and steady efficacy. When drug delivery needs to be interrupted, people just need to take off the patch, thereby being convenient. The invention also has the advantages of good flexibility and appropriate adhesiveness.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to an amlodipine controlled-release patch and a preparation method thereof. Background technique: [0002] The status of calcium channel blockers as first-line antihypertensive drugs has been affirmed in the 1999 WHO / ISH guidelines for the prevention and treatment of hypertension and the 2003 European guidelines for the prevention and treatment of hypertension. According to the circadian rhythm of cardiovascular disease and the damage to target organs caused by the total cardiovascular load in 24 hours, hypertensive patients should try to choose antihypertensive drugs with long half-life or slow and controlled release preparations to keep the blood drug concentration as stable as possible. [0003] Amlodipine is the second-generation 1,4-dihydropyridine calcium antagonist that came out in the mid-1980s. Although its chemical structure is similar to that of nifedipine, it has unique ...

AI Technical Summary

Problems solved by technology

At present, the amlodipine preparations used clinically are mainly tablets, and there are no research reports on amlodipine percutaneous absorption patches at home and abroad.

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