Chitosan and polyvinyl alcohol compound cataplasm matrix and preparing method thereof

A technology of polyvinyl alcohol and chitosan, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, sheet-like delivery, etc., can solve problems such as skin allergies and limited applications, achieve high physiological activity, and improve moisturizing performance , The effect of stable physical and chemical properties

Inactive Publication Date: 2008-07-30
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the matrix formula based on sodium polyacrylate is the most researched, and great progress has been made, but because sodium polyacrylate itself may cause skin allergic reactions, the application of this product is greatly limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The formula of chitosan / polyvinyl alcohol composite cataplasm base contains by weight:

[0026] Chitosan: 0.5g

[0027] Polyvinyl alcohol: 0.75g

[0028] Glutaraldehyde with a mass concentration of 2%: 0.28g

[0029] Glycerol: 2.5g

[0030] Water: 18g

[0031] The preparation method of chitosan / polyvinyl alcohol composite cataplasm matrix, the steps are as follows:

[0032] 1) Add 0.75g of polyvinyl alcohol into 18g of water, and dissolve in a water bath at 80-90°C;

[0033] 2) Add glacial acetic acid to the above solution to form a 1% acetic acid solution, then add 0.5g chitosan, stir at 60°C for 30min to dissolve;

[0034] 3) Add 2.5 g of glycerol and 0.28 g of glutaraldehyde with a mass concentration of 2% in sequence, stir evenly, and statically cross-link for 10 minutes to obtain a hydrogel;

[0035] 4) Spread the prepared hydrogel evenly on the pre-cut non-woven fabric, and then cover it with a polyethylene film.

[0036] Adopt orthogonal test method to the...

Embodiment 2

[0042] The formula of chitosan / polyvinyl alcohol composite cataplasm base contains by weight:

[0043] Chitosan: 0.25g

[0044] Polyvinyl alcohol: 1.25g

[0045] Glutaraldehyde with a mass concentration of 2%: 0.32g

[0046] Glycerol: 3.0g

[0047] Water: 16g

[0048] The preparation method and steps are the same as in Example 1, except that the contents of each component are different.

[0049] Adopt orthogonal test method to the holding power (cohesion), peeling strength of gained matrix, initial adhesion force, skin followability is measured, and the result is:

[0050] Sticking force: hanging time more than 20min

[0051] Peel strength: 0.050 / 0.5kg

[0052] Initial adhesion: 3.00cm

[0053] The skin is quasi-spontaneous: stick it on the skin and shake it 10 times and it will not fall off.

Embodiment 3

[0055] The formula of chitosan / polyvinyl alcohol composite cataplasm base contains by weight:

[0056] Chitosan: 0.75g

[0057] Polyvinyl alcohol: 1.00g

[0058] Glutaraldehyde with a mass concentration of 2%: 0.30g

[0059] Glycerol: 3.5g

[0060] Water: 20g

[0061] The preparation method and steps are the same as in Example 1, except that the contents of each component are different.

[0062] Adopt orthogonal test method to the holding power (cohesion), peeling strength of gained matrix, initial adhesion force, skin followability is measured, and the result is:

[0063] Sticking force: hanging time more than 20min

[0064] Peel strength: 0.020 / 0.5kg

[0065] Initial adhesion: 3.09cm

[0066] The skin is quasi-spontaneous: stick it on the skin and shake it 10 times and it will not fall off.

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PUM

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Abstract

The invention discloses a chitosan or polyvinyl alcohol composite cataplasm matrix. The indigents of the invention and the weight of each indigent are as following: chitosan: 0.25 to 0.75g, polyvinyl alcohol: 0.75 to 1.25g, glutaric dialdehyde with the mass concentration being 2 percent: 0.28 to 0.32g, water: 16 to 20g, propanetriol: twice as much as the sum weight of chitosan and polyvinyl alcohol. The preparation procedure is as following: dissolving the polyvinyl alcohol with water and then adding glacial acetic acid to form acetum which is then added with chitosan until stirring to dissolve; adding propanetriol and glutaric dialdehyde successively, which is statically crosslinked to obtain hydrogel; coating the well-prepared hydrogel on non-woven fabrics evenly and then coating a polyethylene film. The chitosan or polyvinyl alcohol composite cataplasm matrix of the invention does not stimulate skin and has good property.

Description

technical field [0001] The invention relates to a cataplasm (water-based plaster) matrix, especially a chitosan / polyvinyl alcohol composite cataplasm matrix and a preparation method thereof. Background technique [0002] Cataplasm, that is, a water-based plaster, is a plaster made of a water-soluble polymer compound or a hydrophilic substance as a base, combined with a traditional Chinese medicine extract or powder, and is a type of transdermal drug delivery preparation. kind. Because of its convenient use, no allergies and irritation to the skin, no pain and no residue during peeling, it has attracted more and more people's attention. At present, the matrix formula based on sodium polyacrylate is the most researched, and great progress has been made, but the application of this product is greatly limited because sodium polyacrylate itself may cause skin allergic reactions. Contents of the invention [0003] The purpose of the present invention is to provide a chitosan / p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/36
Inventor 胡巧玲崔玮
Owner ZHEJIANG UNIV
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