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Dantrolene sodium chewable tablet and method of preparing the same

A technology for telbivudine and chewable tablets, applied in the field of telbivudine chewable tablets and their preparation, can solve problems such as no chewable tablet preparations, no reports and the like

Inactive Publication Date: 2008-09-03
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] After search and query, there is no chewable tablet preparation of telbivudine according to the present invention in China, and there is no relevant report

Method used

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  • Dantrolene sodium chewable tablet and method of preparing the same
  • Dantrolene sodium chewable tablet and method of preparing the same
  • Dantrolene sodium chewable tablet and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] prescription:

[0020]

[0021] Preparation:

[0022] 1. Pass all the above solid raw and auxiliary materials through a 65-mesh sieve, and set aside;

[0023] 2. Take the prescribed amount of telbivudine and mix it evenly with other excipients, then add 70% ethanol solution to make soft materials. Granulate with 16 mesh sieve, dry at 60°C, granulate with 16 mesh sieve, and set aside;

[0024] 3. Add orange essence to the above granules, mix evenly, adjust tablet weight and pressure to 7-12kgN, and press into tablets.

Embodiment 2

[0026] prescription:

[0027]

[0028] Preparation:

[0029] 1. Take telbivudine, sorbitol, and pregelatinized starch and dry at 80°C for 0.5 to 1 hour;

[0030] 2. Take micronized silica gel, lemon essence, aspartame and 50g of pregelatinized starch and mix them evenly, and then pre-mix other raw materials and auxiliary materials by equal increment method.

[0031] 3. After mixing evenly, adjust the tablet weight and pressure, and press the powder directly into tablets.

Embodiment 3

[0033] prescription:

[0034]

[0035] Preparation:

[0036] 1. Pass all the above solid raw and auxiliary materials through a 65-mesh sieve, and set aside;

[0037] 2. Dissolve curcumin in 2.5% pvp50% alcohol solution and stir evenly;

[0038] 3. Take the prescribed amount of telbivudine and mix it evenly with other excipients, then add the above-mentioned pigment-containing binder solution to make a soft material. Granulate with a 16-mesh sieve, dry at 60°C, granulate with a 16-mesh sieve, and set aside;

[0039] 4. Add acesulfame-K, lemon essence, and talcum powder to the above granules, mix evenly, adjust the tablet weight and pressure to 7-12kgN, and press into tablets.

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PUM

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Abstract

The invention provides a telbivudine chewable tablet for oral administration, and a preparation method and uses thereof. The telbivudine chewable tablet comprises telbivudine as active ingredient and pharmaceutically-acceptable adjuvants including bulking agent, adhesive, correctant and lubricant. The inventive telbivudine chewable tablet has the advantages of good mouthfeel, convenient administration, quick absorption, improved bioavailability and quick action.

Description

technical field [0001] The invention relates to a preparation method and application of an oral telbivudine oral chewable tablet with good taste, convenient taking, rapid absorption, rapid drug absorption, improved bioavailability and rapid onset of effect. Background technique [0002] Hepatitis B is a common infectious disease caused by hepatitis B virus infection. The pathogenesis of hepatitis B is that after hepatitis B virus infects the human body, the virus itself does not directly cause liver cell lesions, but survives and replicates in the liver cells, and the replicated antigen is expressed on the liver cell membrane and stimulated. The body's immune system recognizes and responds to attack and clear the infection. Among them, acute hepatitis B means that the body's immune function is sound and the immune system is activated to recognize the hepatitis B virus to attack the infected liver cells and clear it; chronic hepatitis B means that the body's immune function i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7072A61P1/16A61P31/12
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD