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Incadronate for preparing medicament for preventing and curing osteoporosis

A technology of incadronate disodium and cadronate disodium is applied in the field of incadronate disodium used for preparing medicines for preventing and treating osteoporosis, and can solve the problems of long duration of inhibition of bone resorption and the like

Inactive Publication Date: 2008-09-03
王洪 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bone resorption inhibitory effect lasts for a long time

Method used

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  • Incadronate for preparing medicament for preventing and curing osteoporosis
  • Incadronate for preparing medicament for preventing and curing osteoporosis
  • Incadronate for preparing medicament for preventing and curing osteoporosis

Examples

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Effect test

example 1

[0006] Example 1: Prevention and treatment of rats with osteoporosis caused by retinoic acid by oral administration of disodium incadronate

[0007] 1.1 Preparation of animal models

[0008] Rats (250-320g), half male and half male, totally 50. They were randomly divided into 5 groups: normal control group, model control group, three dose groups of incadronate disodium 0.5639 mg / kg, 3.6712 mg / kg, 10.6418 mg / kg (low, medium and high). Except for the normal control group, the other groups were fed with retinoic acid 65 mg / kg once a day for 2 consecutive weeks. Simultaneously with modeling, each administration group was intragastrically administered 0.15ml / kg according to the set dose, once a day, the control group was given the same amount of vehicle, and the model control group was fed normally for 4 consecutive weeks.

[0009] 1.2 Influence of disodium incadronate on bone mineral density and bending strength of rats with osteoporosis caused by retinoic acid

[0010] The nex...

example 2

[0037] Example 2: Incadronate disodium prevents and treats osteoporosis in ovariectomized rats

[0038] The occurrence of menopause with osteoporosis has been confirmed by many epidemiological studies. Menopause can cause disturbance of glucose metabolism and insulin resistance, and disturbance of glucose metabolism is the main reason for the increase of advanced glycation end products. High levels of advanced glycation end products can lead to decreased number and activity of osteoblasts, decreased bone formation, and ultimately osteoporosis.

[0039] At present, hormone replacement therapy is mainly used in the treatment of postmenopausal osteoporosis. Although it has a certain effect on osteoporosis, it can cause the occurrence of breast cancer and endometrial cancer. The invention adopts ovariectomy method to make rat osteoporosis model, and proves the prevention and treatment effect of incadronate disodium on postmenopausal osteoporosis.

[0040] 1.6 Preparation of anim...

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Abstract

The invention discloses an application of incadronate disodium in preparing drugs for preventing and treating osteoporosis. An animal experiment research finds that the incadronate disodium not only has good preventive and therapeutic effects on osteoporosis in an oophorectomized rat, but also can remarkably increase the bone density and bone calcium content of the rat suffers from retinoic acid-induced osteoporosis. The incadronate disodium can be prepared into any clinically-acceptable oral preparations such as tablet, capsule, granule, suspension and oral liquid for treating primary and secondary osteoporosis and fracture caused by osteoporosis.

Description

technical field [0001] Osteoporosis is a systemic bone disease characterized by damage to the microstructure of bone tissue, a decrease in the proportion of bone mineral components and bone matrix, bone thinning, a decrease in the number of bone trabeculae, increased bone fragility, and increased risk of fracture. Diseases of metabolic disorders. Osteoporosis is the most common disease of the elderly. The invention relates to the application of incadronate disodium in preventing and treating osteoporosis. Bisphosphonate is an endogenous pyrophosphonate analogue, which adheres to the surface of bone hydroxyapatite, replaces the pyrophosphonate in bone matrix, and inhibits excessive bone resorption by osteoclasts, so it can effectively treat bone Metastatic pain. Our research group found that oral incadronate disodium has good preventive and therapeutic effects on osteoporosis. Background technique [0002] In today's society, the incidence of age-related and menopause-rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/6615A61P19/10
Inventor 王洪韩静
Owner 王洪
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