Traditional Chinese medicine containing composition for increasing bone mineral density and preparation method thereof

A technology for increasing bone density and composition, which is applied in the field of composition and its preparation, can solve problems such as slow action, and achieve the effects of hygienic compliance, high degree of automation, and high bioavailability

Active Publication Date: 2013-08-21
BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In daily life, supply sufficient protein, supplement calcium, vitamin D, etc. to prevent and assist in the treatment of osteoporosis. It is safe and has no side effects, but the effect is slow

Method used

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  • Traditional Chinese medicine containing composition for increasing bone mineral density and preparation method thereof
  • Traditional Chinese medicine containing composition for increasing bone mineral density and preparation method thereof
  • Traditional Chinese medicine containing composition for increasing bone mineral density and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0031] Experimental Example 1. Investigation on Alcohol Extraction Process of Epimedium, Rhizoma Drynariae and Achyranthes Radix

[0032] Rhizoma Drynariae, Epimedium and Achyranthes bidentata are commonly used traditional Chinese medicines. The active ingredients of Rhizoma Drynariae are dihydroflavonoids such as naringin, and the active ingredients of Epimedium are flavonoids such as icariin. The active ingredients of Achyranthes bidentata are saponins. This product uses icariin as the symbolic ingredient, and it can be extracted with ethanol to achieve better results.

[0033] Because alcohol extraction has simple and popular equipment, low cost, low production site requirements, easy operation, and is suitable for large-scale industrial production; at the same time, the alcohol extraction method generally adopts the heat reflux method in industry, which can retain active ingredients and achieve the purpose of removing roughness and extracting essence. The main components ...

experiment example 2

[0047] Experimental Example 2: Concentration, drying and pulverization of the extracts of Epimedium, Drynaria and Achyranthes bidentata

[0048] After laboratory research, we have formulated the process concentration conditions and the degree of concentration. The temperature is 70°C and the pressure is 0.08Mpa. Concentrate under reduced pressure, and concentrate to a thick extract with a relative density of 1.15-1.25 (55°C thermal test); dry using Vacuum drying method, drying parameters: temperature is 60°C, vacuum degree is 0.08Mpa, time is 50-60 hours; crushed and sieved, choose 80 mesh sieve; chondroitin sulfate, calcium carbonate, vitamin C, vitamin D 3 , fish collagen powder, and glucosamine hydrochloride were all passed through an 80-mesh sieve. This process has been scaled up by the pilot test to correct the deviation and determine the scientific and reasonable process technical parameters.

experiment example 3

[0049] Experimental example 3, mixing process investigation

[0050] Vitamin D 3 The dosage is very small, and it is used after passing through an 80-mesh sieve. In order to fully mix, it is mixed with an appropriate amount of dextrin by the method of equal increase, and then mixed with other auxiliary materials.

[0051] According to the proportion of 10 times the formula amount, weigh the crushed and sieved medicinal material extract dry paste powder and chondroitin sulfate, calcium carbonate, fish collagen powder, glucosamine hydrochloride, vitamin C, vitamin D 3 Put the mixed powder with dextrin in the mixer, stop mixing after 10 minutes, take out the mixed material, and take about 3 grams of samples from the upper left, upper right, middle, lower front, and lower back respectively. After sampling, mix the mixture again Put it in the mixer and continue mixing. After that, take a sample according to the above method at intervals of 10 minutes, until it is mixed for 50 min...

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Abstract

The invention discloses a multicomponent traditional Chinese medicine containing composition for increasing bone mineral density and a preparation method thereof. The composition comprises the traditional Chinese medicine raw materials in parts by weight: 400-500 parts of herba epimedii, 400-500 parts of Rhizoma Drynariae, 300-400 parts of achyranthes root and also comprises the following nutritional substances in parts by weight: 75-95 parts of calcium carbonate, 40-60 parts of fish collagen powder, 20-38 parts of chondroitin sulfate, 5-6.2 parts of glucosamine hydrochloride, 10-13 parts of vitamin C and 0.0003-0.0004 parts of vitamin D. According to conventional process, an oral solid preparation is prepared by extracting herba epimedii, Rhizoma Drynariae and achyranthes root by ethanol and mixing the ethanol extract and the nutritional substances and appropriate amount of auxiliary materials. The medical composition provided by the invention has the function of increasing bone mineral density and can be used for prevention and assistant treatment of osteoporosis.

Description

technical field [0001] The invention relates to a composition and a preparation method thereof, in particular to a composition containing traditional Chinese medicine for increasing bone density and a preparation method thereof. Background technique [0002] At present, with the acceleration of population aging, the incidence of osteoporosis has jumped to the seventh place in the incidence of various common diseases, and 90% of elderly women and 66% of elderly men suffer from this disease. Clinically, as long as a patient has a fragility fracture or low bone mineral density (BMD), it can be diagnosed as osteoporosis. In modern clinical medicine, the drugs for the treatment of osteoporosis mainly include: ① anti-bone resorption drugs, such as bisphosphonates, calcitonin, estrogen, etc.; ② drugs that promote bone formation, such as PTH (parathyroid hormone ); ③ calcium agents, such as calcium carbonate, active calcium, calcium gluconate, calcium lactate, etc.; ④ vitamin D dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61K38/39A61P19/10A23L1/29A23L1/303A23L1/304A23L1/305A61K33/10A61K31/737A61K31/7008A61K31/375A61K31/593A23L33/00A23L33/155
Inventor 迟玉明周天浩牟艳英李晋生吴炜刘名徐意
Owner BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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