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Technique for preparing potassium sodium dehydroandroandrographolide succinic by using potassium dehydroandrographolide succinate

A technology of andrographolide and Chuanhuning, which is applied in antipyretics, organic chemistry, non-central analgesics, etc., can solve the problems of unstable pH value of preparations, incomplete removal of impurities, low product yield, etc., and achieve less impurities , Reduce energy consumption, high product purity

Active Publication Date: 2008-09-10
CHANGCHUN MAILING BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a process for preparing potassium sodium salt of andrographolide half-ester succinate using Chuanhuning as a raw material, which solves the problem of low yield and low content of the product in the existing preparation process, unstable pH value of the prepared preparation, and removal of impurities incomplete question

Method used

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  • Technique for preparing potassium sodium dehydroandroandrographolide succinic by using potassium dehydroandrographolide succinate
  • Technique for preparing potassium sodium dehydroandroandrographolide succinic by using potassium dehydroandrographolide succinate
  • Technique for preparing potassium sodium dehydroandroandrographolide succinic by using potassium dehydroandrographolide succinate

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Embodiment 1

[0140] Weigh 200g of Chuanhuning, add 650ml of absolute ethanol to make a suspension, weigh another 29.5g of sodium bicarbonate, add water to dissolve it in a water bath, add the Chuanhuning suspension in a 45°C water bath dropwise sodium bicarbonate solution, slowly Add dropwise and stir until the liquid medicine is clear and impurities are precipitated out at the same time, pass through a 0.22 μm membrane, add 1500ml of absolute ethanol under stirring, stir for 10 minutes, and let it stand at room temperature for 15 hours to naturally crystallize. Filter, wash twice with 1000ml of absolute ethanol, filter, and dry under reduced pressure at 50°C to obtain 176g of light yellow powder.

Embodiment 2

[0142] Weigh 400g of Chuanhuning, add 2000ml of absolute ethanol to make a suspension, weigh another 63.2g of sodium bicarbonate, add water to dissolve it in a water bath, add the Chuanhuning suspension in a 50°C water bath dropwise with sodium bicarbonate solution, slowly Slowly add dropwise and stir until the liquid medicine is clear and impurities are precipitated at the same time. After passing through a 0.22μm membrane, add 3600ml of absolute ethanol under stirring, stir for 20 minutes, and let it stand at room temperature for 18 hours to naturally crystallize. Filter, wash 3 times with 2300ml of absolute ethanol, filter, and dry under reduced pressure at 55°C to obtain 336g of light yellow powder.

Embodiment 3

[0144] Weigh 600g of Chuanhuning, add 3600ml of absolute ethanol to make a suspension, weigh another 91.3g of sodium bicarbonate, add water to dissolve it in a water bath, add the Chuanhuning suspension in a 60°C water bath dropwise with sodium bicarbonate solution, slowly Slowly add dropwise, stir until the liquid medicine is clear, and impurities are precipitated at the same time, pass through a 0.22 μm membrane, add 7200ml of absolute ethanol under stirring, stir for 30 minutes, and stand at room temperature for 20 hours, and crystallize naturally. Filter, wash 3 times with 3600ml of absolute ethanol, filter, and dry under reduced pressure at 60°C to obtain 498g of light yellow powder.

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Abstract

The invention discloses a process of preparing Dehydroandrographolide Succinate Sodium and Potassium salts with Potassium Dehydroandrograpolide Succinate. The process comprises the steps of: weighing right amount of Potassium Dehydroandrograpolide Succinate, adding absolute ethyl alcohol about 3 to 6 times to make suspension; weighting mole Sodium bicarbonate in equal weight, adding water to dissolve, dripping slowly Sodium bicarbonate solution in potassium dehydroandrograpolide succinate suspension in a water bath at a temperature of between 40 and 60 DEG C, mixing into liquid medicine and defecating, dissolving impurity and filtering, putting on a 0.22 mu m filter membrane, adding absolute ethyl alcohol about 7 to 12 times while mixing, after 10 to 30 minutes of mixing, natural crystallization seeds out after 13 to 18 hours standing in room temperature; filtering and washing 2 to 3 times with right amount of absolute ethyl alcohol; filtering and drying with less pressure. The invention provides a process route of preparing potassium sodium dehydroandroan drographolide succinate for injection with high purity, which is high in process yields, high in product purity, good in solubility, less in impurity and complete in combination of Potassium and Sodium; no obvious toxic and side effect in clinic application, the preparation is more stable compared with the similar and can be prepared into various preparations.

Description

technical field [0001] The invention discloses a process for preparing potassium half ester succinate sodium salt of andrographolide by using Chuanhuning as a raw material, which is an optimization and improvement of the existing production process and belongs to the technical field of chemical medicine preparation. Background technique: [0002] The present invention relates to dehydroandrographolide potassium half ester succinate sodium salt (common name: Yanhuning), chemical name is: 14-dehydroxyl-11,12-didehydroandrographolide-3,19-di Potassium succinate half ester sodium salt, the main structure is dehydroandrographolide succinate half ester, which has the functions of clearing heat, antibacterial, anti-inflammatory, and antiviral; the traditional process currently used includes using chuanhuning and sodium bicarbonate as raw materials, generating acid in water Alkali neutralization reaction, sterile filtration, and freeze-drying to prepare Yanhuning, the product yield ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/58A61P29/00A61P31/12
Inventor 杜宏明高强苏中孙玉芹
Owner CHANGCHUN MAILING BIOLOGICAL ENG CO LTD
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