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Lamb stomach extract vitamin B12 preparations composing prescription

An extract and B12 technology, applied in the field of lamb stomach extract vitamin B12 formulations, can solve the problems of ulcers with no protective effect and inapplicability, and achieve the effects of advanced production equipment, significant curative effect, and promotion of therapeutic effect.

Active Publication Date: 2008-09-17
XINJIANG BIOCHEM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the existing gastric medicine prescriptions, there are only a small amount of biological raw materials, but because there is no vitamin B 12 , has no protective effect on ulcers caused by phenylbutamine. Therefore, some gastric medicines are not suitable for treating atrophic gastritis, superficial gastritis, and erosive gastritis.

Method used

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  • Lamb stomach extract vitamin B12 preparations composing prescription
  • Lamb stomach extract vitamin B12 preparations composing prescription
  • Lamb stomach extract vitamin B12 preparations composing prescription

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] The upper part of the lamb’s fourth stomach is cut from the end of the third stomach, and the lower part is cut from the upper part of the duodenum. After the raw material is washed with running water to remove the stomach content, the fat and connective tissue are peeled off, frozen at -20 ° C, low temperature After mincing, put it in the warehouse at -10℃~10℃ to break the wall and autolyze. Then add 0.5%-2.0% NaCl solution 5 times, stir and extract for 4 hours, then filter with a vibrating sieve, add 2 times the amount of 0.5-2.0% NaCl solution, stir and extract for 2 hours, combine the filtrates, and discard the residue. Stir the filtrate with 2mol / L HCl to adjust the pH to 1.5-4.0, add 1% precipitant with stirring at a temperature of 0-15°C, and centrifuge at 3000r / min after standing for 24 hours to obtain a precipitate.

[0032] The supernatant was taken, concentrated in vacuum at a temperature below 50°C, and then boiled and dried to obtain a dry product.

[0033...

example 1

[0182] Tao Hong, male, 42 days old, milk-fed, often vomited milk within 2 hours after feeding for nearly a month, about 4-5 times a day, good energy, appetite, normal stool, once took digestive aids, vitamin B6, phenagen , morphine, etc. are invalid, taking "lamb stomach extract vitamin B 12 Capsule "after the treatment, the vomiting stopped on the next day, and continued to take the medicine for observation for a week without vomiting.

example 2

[0184] Chen Jianguo, male, 20 days old, milk-fed, often vomited 5-6 times after breastfeeding since birth, defecated 2-3 times / day, normal in nature, took "lamb stomach extract vitamin B 12 The vomiting stopped on the second day after the "capsule", and the stool was reduced to 1-2 times / day on the third day. Continue to take the medicine and observe for a week without vomiting.

[0185] The quality standard of lamb stomach extract stipulates:

[0186] 1. Determination of curd potency

[0187] Preparation of chymosin substrate solution Take 12g of whole milk powder, add calcium chloride solution (take 2.05g of sodium acetate, 1.11g of calcium chloride, add water to dissolve into 1000ml, adjust the pH value to 6.3±0.1) in an appropriate amount, and grind evenly , put it in a 100ml measuring bottle, add calcium chloride solution to the mark, and shake well. This solution should be freshly prepared before use.

[0188] Preparation of Standard Solution Take an appropriate amoun...

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PUM

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Abstract

The invention provides a formulation of B12 extracted from the gastric of lambs. The material extracted from the gastric of lambs is the total extracts from the forth gastric of the lambs; when calculated as the dried material, the rennet activity in each gram is not less than 800 units, and the stomach cnzyme activity is not less than 230 units; the ratio of rennet activity and the stomach cnzyme activity is 2.0 to 4.1. The ratio can clinically avoid side effects caused by too high stomach cnzyme activity; the invention can be used for patients of gastritis with erosion, hyperemia and ulcer, and can also treat anorexia, diarrhea and milk vomiting of babies. The formulation of B12 extracted from the gastric of lambs has simple manufacturing process and does not use organic solvent.

Description

technical field [0001] The invention relates to lamb stomach extract vitamin B 12 Prescription Background technique [0002] In the existing gastric medicine prescriptions, there are only a small amount of biological raw materials, but because there is no vitamin B 12 , has no protective effect on ulcers caused by phenylbutamine. Therefore, some stomach medicines are not suitable for treating atrophic gastritis, superficial gastritis, and erosive gastritis. Contents of the invention [0003] The object of the present invention is to provide a kind of medicine that can not only treat atrophic gastritis, superficial gastritis, but also treat erosive gastritis, and also have significant curative effect on duodenal ulcer, especially for erosive gastritis caused by tricarboxylic acid. It has a good effect of promoting treatment. The formulation process of the preparation is simple, and the treatment effect is good. [0004] To achieve the above object, the present invention...

Claims

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Application Information

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IPC IPC(8): A61K35/38A61P1/04A61K31/714A61K35/57
Inventor 赵新民
Owner XINJIANG BIOCHEM PHARMA CO LTD
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