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Self-adaption finite element light source reconstruction method based on simple spectrum or mix segment measurement

A finite element, self-adaptive technology, applied in diagnostic recording/measurement, application, medical science, etc., can solve problems such as aggravating autofluorescence tomography morbidity, increasing numerical instability and computational cost, etc., and achieves balanced mesh division degree and algorithm efficiency, solving ill-conditioned problems, improving efficiency and robustness

Inactive Publication Date: 2008-10-29
INST OF AUTOMATION CHINESE ACAD OF SCI
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Problems solved by technology

However, over-fine meshing will aggravate the ill-conditioned nature of autofluorescence tomography, increasing numerical instability and computational cost

Method used

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  • Self-adaption finite element light source reconstruction method based on simple spectrum or mix segment measurement
  • Self-adaption finite element light source reconstruction method based on simple spectrum or mix segment measurement
  • Self-adaption finite element light source reconstruction method based on simple spectrum or mix segment measurement

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Embodiment Construction

[0027] The present invention will be described in detail below in conjunction with the accompanying drawings. It should be noted that the described embodiments are only intended to facilitate the understanding of the present invention, rather than limiting it in any way.

[0028] Specific embodiments of the present invention such as figure 1 The experimental flowchart for autofluorescence tomography is shown as follows:

[0029] 1. Using the light source characteristic parameters and anatomical structure information of the reconstructed target area, the reconstructed target area is divided into a priori feasible light source area and a priori forbidden light source area.

[0030] 2. At the boundary of the reconstructed target area, use a high-sensitivity optical detection instrument (such as a liquid nitrogen-cooled CCD detector) to perform single-spectrum or mixed-spectrum detection of the escaped photons to obtain the boundary escape luminous flux Q(r).

[0031] 3. Using th...

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Abstract

The present invention discloses a self-adaptive finite element optical source rebuilding method based on single spectrum or mixed spectrum measurement. A prior feasible optical source area and a prior forbidden optical source area are confirmed by the optical characteristic parameter and the dissection structure information of a target rebuilding area. Partial gridding is optimized and decomposed by single spectrum or mixed spectrum light flux measurement data at the boundary of the target rebuilding area to be combined with multilevel self-adaptive finite element and a posteriori error estimation method, so as to obtain a fluorescent optical source inside the target rebuilding area. Therefore, based on the single spectrum or mixed spectrum boundary measurement data, the method of the present invention adopts the prior feasible optical source area to reduce the morbidity characteristic of bioluminescence tomography and ensures that the present invention can confirm the only solution; the self-adaptive finite element method is used for balancing gridding partitioning degree, algorithm efficiency and value stability and the partial gridding is optimized according to the posteriori error estimation, which improves quality, efficiency and robustness of the fluorescent optical source rebuilding.

Description

technical field [0001] The invention belongs to the field of molecular imaging, and relates to an in-body fluorescence tomography algorithm, in particular to an adaptive finite element light source reconstruction method based on single-spectrum or mixed-spectrum measurement. Background technique [0002] Autofluorescence tomography is an emerging optical molecular imaging technology in recent years. Autofluorescence uses luciferase to mark the reconstruction target. In the presence of ATP and oxygen, if luciferase encounters the substrate luciferin, luciferase Will catalyze the oxidation of fluorescein and generate photons, the intensity of which is proportional to the number of labeled targets. Outside the reconstruction target area, the photons escaping from the reconstruction target area can be detected directly by using high-sensitivity optical detection instruments, and then the position and intensity of the fluorescent light source inside the reconstruction target area...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00G06F17/10
Inventor 田捷吕玉杰秦承虎杨鑫
Owner INST OF AUTOMATION CHINESE ACAD OF SCI
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