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Prescription of low-dose condensed type Mai jun an tablet or capsule and preparation thereof

A concentrated, high-dose technology, which is applied to medical preparations containing active ingredients, capsule delivery, and pharmaceutical formulations. It can solve the problems of unstable preparation quality, backward preparation methods, and large dosages, and achieve indicators that are easy to quantify and quality Controllable, small dose effect

Inactive Publication Date: 2008-11-05
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation method of the above-mentioned Maijunan preparation is relatively backward, and the two kinds of Chinese medicinal materials (Uncaria, Puerariae) are simply crushed, partially extracted, and then mixed with hydrochlorothiazide and supplementary materials according to the prescribed dosage.
Therefore, the Maijunan preparations currently produced and sold all have problems such as complex components, unstable preparation quality, and large dosages.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Pueraria lobata is pulverized through 80 mesh sieve, weighs 100g, adds 70% ethanol in the ratio of 1:12 (m / V) by solid-liquid ratio, extracts 120min under the condition that extraction temperature is 80 ℃, obtains lobata root total flavonoids extract 100ml, add concentrated hydrochloric acid to adjust the pH to 1-2 to make an acidic solution as a spare solution for the purification process.

[0020] Take about 300g of D101 macroporous adsorption resin, and wet-pack the column with ethanol, first wash with absolute ethanol until the effluent is not cloudy after adding water, and then wash with purified water until the effluent is clear. Put the spare solution on the column, wash it with water until it is neutral, and elute it with 50% ethanol with a pH of 1 to 2, until there are no spots in the eluent by thin-layer detection, recover the ethanol from the eluent under reduced pressure, concentrate, and evaporate the concentrated solution to dryness in a water bath. Dried ...

Embodiment 2

[0022] Grind Uncaria medicinal material, weigh 100g and immerse in 1000ml of 80% ethanol and 0.1% hydrochloric acid mixture at 25°C for 12h, then place in 1000ml of 80% ethanol and 0.1% hydrochloric acid mixture at 60°C After warming for 3 hours, filter with suction, combine the filtrates, recover ethanol under reduced pressure at 60°C, and concentrate the mixed solution after recovering ethanol to obtain a concentrated solution with a pH of 2-3. Put the concentrated solution into a separatory funnel, alkalinize it with concentrated ammonia water to pH 10-11, then extract with chloroform and recover the chloroform to obtain 3.47 g of total alkaloids.

[0023] The pretreated macroporous adsorption resin is packed into the chromatographic column, and the resulting total alkali is formulated into 35 ml of solution and slowly applied to the column for adsorption, left to stand for 0.5 h, and eluted with 280 ml of 0.08 mol / l hydrochloric acid as the eluent to The effluents were com...

Embodiment 3

[0025] Accurately weigh 8g / 500g of hydrochlorothiazide, 260g / 500g of total flavonoids of kudzu root (content 80%), 120g / 500g of total alkaloids of Uncaria (content 50%), add 112g / 500g of auxiliary agents, excipients to compress tablets or fill capsules 1000 capsules. The product specification is 0.5 g / tablet or capsule, and the oral dosage is 1 tablet or capsule at a time, 3 times a day.

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Abstract

The invention provides maijun'an tablets or capsules for lowering blood pressure which have more significant effect, safety, and no toxicity or side effect, thus achieving the purpose of effectively lowering the blood pressure under the situation of taking smaller dose. The adopted method is to respectively carry out separation and purification of active ingredients for lowering the blood pressure in kudzuvine root and gambir plant, thus obtaining total flavonoids of the kudzuvine root with the purity of over 80 percent and total alkaloids of the gambir plant with the purity of over 50 percent. 8g / 500g of hydrochlorothiazide, 260g / 500g of the total flavonoids of the kudzuvine root, 120g / 50g of total alkaloids of the gambir plant and 112g / 500g of auxiliary agents are added for preparing tablets, pills or capsules. The concentrated maijun'an tablets or capsules of the invention do not only have small administration dose, but also have significant efficacy, controllable quality and easily quantified indicators, thus facilitating the standardized production of the pharmaceutical composition preparation for lowering the blood pressure.

Description

technical field [0001] The invention relates to a traditional Chinese medicine prescription for reducing blood pressure and a preparation method thereof, in particular to a concentrated Maijun'an tablet or capsule formula with a small dosage and a preparation method thereof. Background technique [0002] Hypertension is a common disease, frequently-occurring disease. With the improvement of living standards, changes in dietary structure, and accelerated pace of work, the incidence of hypertension has gradually increased. At present, most of the antihypertensive drugs commonly used by hypertensive patients are chemical drugs, which have many side effects and are prone to drug resistance after long-term use. The commonly used antihypertensive Chinese patent medicines have the disadvantages of taking large doses and slow onset of effect. The prescription of Maijunan preparation (tablets and capsules) of Chinese patent medicine is Uncaria 1470g, hydrochlorothiazide 1.5g, and Pu...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/20A61K9/48A61P9/12A61K31/549
Inventor 陈勇韩凤梅张继业张仙王恒松
Owner HUBEI UNIV
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