Particles with superparamagnetism and method for manufacturing same

A technology of superparamagnetic particles and manufacturing methods, applied in the direction of inorganic material magnetism, iron oxide/iron hydroxide, etc., can solve the problems of application limitations, inability to withstand high temperature and acid resistance for a long time, and achieve wide application and good acid resistance Effect

Active Publication Date: 2008-11-19
TAIWAN ADVANCED NANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, the surface of iron ferric oxide particles is coated with high molecular polymer or inorganic oxide of silicon dioxide, but these particles often have the disadvantages of being unable to withstand high temperature for a long time and poor acid resistance, which limits their application.

Method used

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  • Particles with superparamagnetism and method for manufacturing same
  • Particles with superparamagnetism and method for manufacturing same
  • Particles with superparamagnetism and method for manufacturing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1: Small-scale preparation of superparamagnetic iron oxide particles

[0062] Dissolve 0.25 grams of ferric chloride powder and 6 grams of urea crystal particles in 100 milliliters of deionized water, stir rapidly in a glass reactor equipped with a condenser tube for 10 minutes to form a yellow-green clear solution, and transfer it to an oil pan at 90°C for After 12 hours of reflux reaction, black iron oxide particles were formed. After standing for precipitation, the nearly clear supernatant was poured out, and the precipitate was washed three times with deionized water to remove ammonium ions and chloride ions left in the reaction. Prior to silica coating, the aforementioned precipitate was kept in an aqueous solution to avoid drying.

Embodiment 2

[0063] Example 2: Mass Preparation of Superparamagnetic Iron Oxide Particles

[0064]Dissolve 60 grams of ferric chloride powder and 90 grams of urea crystal particles in 1 liter (1000 ml) of deionized water, stir rapidly for 3 minutes in a glass reactor equipped with a condenser tube, and transfer the mixture to a temperature of 95°C The oil pan was refluxed for 12 hours to generate black iron oxide particles. After standing for precipitation, the nearly clear supernatant was sucked out, and the precipitate was washed three times with deionized water to remove the ammonium ions and chloride ions left in the reaction. Prior to silica coating, the aforementioned precipitate was kept in an aqueous solution to avoid drying.

Embodiment 3

[0065] Embodiment 3: coating of silicon dioxide

[0066] 30 grams of iron oxide particles prepared in Example 1 or Example 2 were dispersed in 225 milliliters of deionized water, then 22.5 milliliters of 28% ammonia water was added, and then 900 milliliters of isopropanol was added, and the solution was sealed in a glass reactor Stir continuously and ultrasonically shake for 10 minutes. Add 4.5 ml of tetraethyl silicate, raise the water temperature to 50°C, and continue the reaction for 2 hours; then lower the water temperature to room temperature (about 25°C), then add 4.5 ml of tetraethyl silicate, and continue the reaction 1 hour. After the reaction is completed, let it stand for precipitation, suck out the transparent supernatant, and wash it with deionized water until there is no smell of ammonia water and isopropanol. The image figure of the superparamagnetic particle coated with silicon dioxide that is made in embodiment 3 is as follows figure 1 shown.

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Abstract

The invention provides a super paramagnetic particle and a method for making the same. The method comprises the following steps that: ferro compound powder, carbamide and water are mixed and stirred, and the mixture undergoes the back flow reaction under the conditions of the normal pressure and the temperature between 80 and 110 DEG C for 1 to 24h to obtain ferric oxide particles; the ferric oxide particles are washed, added with water, ammonia water and organic alcohol solvent and stirred, and the mixture undergoes the ultrasonic vibration; the mixture is added with tetraethl silicate and reacts with tetraethl silicate at a temperature of between 50 and 70 DEG C for 0.5 to 12h; products obtained by mixing at a temperature of 70 DEG C are cooled down to a temperature of between 25 and 30 DEG C and added with tetraethl silicate to react for 1 to 12h, and finally the ferric oxide particles with super paramagnetism which are covered by silicon dioxide are obtained. The invention also provides a super paramagnetic particle prepared by the method.

Description

technical field [0001] The invention provides a method for manufacturing superparamagnetic particles and superparamagnetic particles manufactured by the method. The superparamagnetic particle can be applied to the purification and reaction of chemical or biochemical substances, and can be applied to large-scale reaction and automatic magnetic bead operation platform. Background technique [0002] Superparamagnetic particles (superparamagnetic particles), under the condition of an external magnetic field, will be induced by the magnetic field to generate magnetism, and gather to the N pole or S pole of the magnetic field; after the magnetic field is removed, its magnetism will disappear instantly and recover To a non-magnetic state, re-disperse. Iron oxide particles are the most widely used of all magnetic particles due to their biocompatibility and non-cytotoxicity. [0003] In the early application and research of magnetic particles with superparamagnetism, their particle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/02B22F1/02C04B35/628H01F1/11
Inventor 杨裕胜
Owner TAIWAN ADVANCED NANOTECH
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