Chinese medicinal composition for preventing and controlling alcoholic liver damnification and preparation method thereof

A technology of alcoholic liver injury and composition, applied in the field of medical preparations, can solve problems such as excited respiratory rate, unavoidable decline in human immunity, increased gastric acid heartburn, etc.

Inactive Publication Date: 2008-12-10
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drink "Hovenia Hoveniae Decoction" composed of Hovenia dulcis and Pueraria lobata root is recognized by doctors of all dynasties as an essential prescription for relieving hangovers. Avoid alcoholic liver damage and human immune decline caused by long-term drinking
Later generations improved this prescription, as disclosed in the invention patent of CN1528429 "A traditional Chinese medicine preparation with auxiliary protective effect on alcoholic liver injury and its preparation method", which is prepared from the following raw materials in weight ratio: The prepared Chinese medicine preparations: 29-35% of kudzu root, 19-25% of Hovenia dulcis, 19-25% of schisandra, 9-15% of astragalus and 9-15% of tangerine peel. Animal experiments and case studies have proved that the preparation can significantly reduce The concentration of alcohol in blood and tissue has a good therapeutic effect on acute alcoholic liver injury, but there is no evidence that the preparation has a preventive effect on chronic alcoholic liver injury; and the schisandra used in the preparation is slightly toxic and can Exciting the respiratory center can increase the frequency and amplitude of breathing, and it can also increase gastric acid and cause heartburn, so it is not suitable as a hangover drug that is often taken

Method used

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  • Chinese medicinal composition for preventing and controlling alcoholic liver damnification and preparation method thereof
  • Chinese medicinal composition for preventing and controlling alcoholic liver damnification and preparation method thereof
  • Chinese medicinal composition for preventing and controlling alcoholic liver damnification and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0091] Embodiment 1: make tablet

[0092] Add 1 part of Hovenia dulcis, 1 part of Pueraria root and 10 parts of Wuzhi Maotao into 60% ethanol, heat and reflux to extract twice, the amount of ethanol added each time should not exceed the medicinal surface, combine the two extracts, filter, and reduce at 80 ° C. Press to recover ethanol, condense into an extract with a specific gravity of 1.1-1.35, dry at 105°C to form a dry extract, crush the dry extract into powder, add starch and carboxymethyl cellulose, mix evenly, granulate, and tablet , coated, made into tablets.

Embodiment 2

[0093] Embodiment 2: make hard capsule

[0094] Add 75% ethanol to 1 part of Hovenia dulcis, 1 part of kudzu root and 1 part of Wuzhi Maotao, heat and reflux for extraction twice, the amount of ethanol added each time is preferably no more than the medicinal surface, and the extracts are combined, and the ethanol is recovered under reduced pressure at 65 ° C. Concentrate into an extract with a specific gravity of 1.1-1.35, spray dry to obtain a spray-dried powder, granulate, pack into hard gelatin capsules, and make hard capsules.

Embodiment 3

[0095] Embodiment 3: make soft capsule

[0096] Add 70% ethanol to 1 part of Hovenia dulcis, 2 parts of kudzu root and 8 parts of Wuzhi Maotao, heat and reflux for extraction twice, each time for 3 hours. The ethanol is recovered, concentrated into an extract with a specific gravity of 1.1-1.35, spray-dried to obtain a spray-dried powder, added with vegetable oil, mixed uniformly, filled into soft capsules, and made into soft capsules.

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Abstract

The present invention provides a traditional Chinese medicine combination for preventing and remedying the alcoholic liver damage. The combination consists of active component and medically acceptable auxiliary materials, wherein, the active component is made from the raw material medicines with the weight proportions of 1 to 10 portions of fruitsemen Hoveniae, 1 to 10 portions of kudzuvine roots and 1 to 10 portions of radix fici simplicissimae. The combination uses the fruitsemen Hoveniae as a monarch drug which relieves alcoholism and is diuretic; the kudzuvine root is used as an associate drug which expels evil factors from the muscles and promoting secretion; the radix fici simplicissimae is used as an envoy drug which eliminates damp to promote the circulation of qi and tonifies qi to strengthen the healthy qi. Three drugs are combined for using and take effects of dispelling damp and stasis, relieving alcoholism and relaxing liver together, and the traditional Chinese medicine combination can also improve the body immunological competence.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a medical preparation using plants as raw materials. Background technique [0002] Alcoholic liver injury refers to a series of diseases such as liver damage caused by excessive intake of alcohol. Alcoholic liver injury can be divided into acute alcoholic liver injury and chronic alcoholic liver injury. Acute alcoholic liver injury is the liver function damage caused by excessive alcohol intake at one time, manifested as acute hepatitis symptoms such as loss of appetite, nausea, liver discomfort and jaundice. Chronic alcoholic liver injury is the fibrosis and necrosis of liver cells caused by long-term alcohol intake, and the immune function of the liver is destroyed. It often manifests as alcoholic fatty liver, alcoholic hepatitis and alcoholic liver cirrhosis. [0003] Drugs for the treatment of alcoholic liver injury mainly include: anti-endotoxin drugs, antioxidants, glucocorticoids...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/72A61P1/16
Inventor 赖小平苏子仁陈建南
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
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