Preparation of sedative and brain-invigorating oral liquid

Abstract

The present invention relates to a preparation technique of a tranquilizer, in particular to the improvement of the preparation technique of the tranquilizer, which relates to the technical field of Chinese medicine preparation. The improved preparation technique includes the following steps: in the process of the preparation of tranquilizer extract, extract solution is filtered by an ultramicro filter membrane with a pore diameter between 20mm and 200mm, and after being collected, clear solution is concentrated, so that the tranquilizer extract is finally obtained; in the process of the preparation of the tranquilizer, the mixed liquor is filtered by a tubular ultrafiltration membrane device, the molecular weight cutoff of the membrane pore diameter is between 5000 and 200000, the filtering pressure is between 0.1MPa and 0.4 MPa, the filtering temperature is between 0 DEG C and 40 DEG C, and the membrane flux is between 50L / m<2>h and 300L / m<2>h. The adoption of the ultramicro filter membrane reduces the usage of ethanol and even can realize non-ethanol production, the production period is shortened, and the production cost and the energy consumption are reduced. At the same time, since the filtering technique of the tubular ultrafiltration membrane is adopted to terminally filter the prepared liquor, the clarity of the liquor is improved, the product quality is increased, and the stability of the product quality is ensured.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to the improvement of the preparation process of Anshen Bunao Liquid. Background technique [0002] Anshen Bunao Liquid is a traditional Chinese medicine liquid preparation refined from pilose antler, Polygonum multiflorum, Epimedium, dried ginger, jujube, licorice, and vitamin B1. Insomnia, forgetfulness, headache and other diseases are widely welcomed by consumers. However, due to the limitations of the traditional production process, like other traditional Chinese medicine oral preparations, it is prone to precipitation during production and storage, which is more obvious after prolonged storage, and the product quality stability is poor. [0003] In the 2005 edition of "Chinese Pharmacopoeia", the preparation process of Anshen Bunao Liquid has been disclosed, including step 1 to prepare velvet antler extract; step 2 to extract dried ginger volatile...

AI Technical Summary

Problems solved by technology

However, in actual production, Chinese herbal medicines are bulky, consume a lot of ethanol, consume a lot, cost is high, and have a low boiling point, which is not conducive to safe production, poor safety, long cycle, high labor intensity, and poor production environment.

[0005] Traditional talcum powder filter-aid plate frame filter is generally used to filter and refine the traditional Chinese medicine liquid in the preparation process of Anshen Bunao liquid. Since this filtering method depends on the shape of the talc powder filter cake, when the amount of talc powder is inappropriate or the operation fails At that time, the talcum powder filter cake will not be tight, which will seriously affect the filtering effect of the liquid medicine, so that the clarity of the liquid medicine cannot meet the requirements, so it is necessary to re-prepare the talc powder filter cake to repeat the filtration of the liquid medicine, resulting in prolonged operation time. cumbersome, still can not guarantee product quality

[0006] Chinese patent CN 100998846A discloses a membrane production process of Anshen Bunao liquid. In the pre-extraction, a ceramic membrane filtration process is used instead of coarse filtration. The pore size is 0.22um, and the membrane pore size is relatively large, which still cannot completely replace the effect of the alcohol precipitation process, so the liquid medicine still needs to be processed, otherwise the clarity of the product cannot be guaranteed

[0009] (2) The hollow fiber membrane polypropylene (PP) material is easy to break, and the working pressure is only 0.1mpa. It is not easy to find after the break, which affects the separation effect

[0010] (3) The microporous flow channel of the hollow fiber membrane is a finger-like pore structure, and the inner and outer skin layers are easy to deposit pollutants and difficult to clean.

[0011] (4) The hollow fiber membrane channel is small, less than 1 mm, the material flow resistance is large, and the flux per unit square is small

[0012] (5) Hollow fiber membrane external pressure dead-end filtration form, no fixed flow channel, no discharge (or small discharge) of retentate, fast fouling, many dead ends, incomplete cleaning, affecting the quality of subsequent products

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