Moisture absorption humectant employing trehalose quaternary ammonium salt and preparation thereof

A technology of trehalose and quaternary ammonium salt, applied in the field of daily chemicals, can solve the problems of high extraction cost, trehalose cannot meet market needs, cannot be chemically synthesized, etc., and achieves the effects of high hygroscopic and moisturizing performance, low cost and high yield

Inactive Publication Date: 2011-06-22
烟台大境生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The resource of trehalose is more extensive than that of hyaluronic acid, but it is still a high value-added product, which cannot be chemically synthesized, and the extraction cost is relatively high
Therefore, trehalose cannot meet the needs of the market at present.

Method used

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  • Moisture absorption humectant employing trehalose quaternary ammonium salt and preparation thereof
  • Moisture absorption humectant employing trehalose quaternary ammonium salt and preparation thereof
  • Moisture absorption humectant employing trehalose quaternary ammonium salt and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Preparation of trehalose quaternary ammonium salt: 1g trehalose (see figure 1 ) was added 10mL isopropanol, then 0.25g NaCl (5%) was added to prevent swelling, the pH was adjusted to 11 with NaOH, and the etherifying agent 2,3-epoxypropyltrimethylammonium chloride (25%, MW =188.1) 7.96mL, stirred and reacted in a water bath at 40°C for 7-9h, neutralized with acetic acid or hydrochloric acid to a pH of 6.0-7.0, washed with an appropriate amount of methanol, suction filtered, and dried at 50°C to obtain trehalose quaternary ammonium salt ( see figure 2 ).

[0016] From figure 2 It can be seen that compared with trehalose, 1482cm -1 and 3016cm -1 The absorption peak at place is the characteristic absorption peak of quaternary ammonium group (Liu Zemin, Zhang Yuqing, Wang Jinggang, Hu Junjun; Synthesis of 2,3-epoxypropyltrimethylammonium chloride by phase transfer autocatalysis; Journal of Henan University of Science and Technology, Natural Science Edition, 2006, 27:...

Embodiment 2

[0019] The difference from Example 1 is:

[0020] Preparation of trehalose quaternary ammonium salt: add 1g trehalose to 12.5mL isopropanol, then add 0.3g NaCl (5%) to prevent swelling, adjust pH=11 with NaOH, add etherifying agent 2,3-epoxypropyl Trimethylammonium chloride (25%) 9.95mL, stirred and reacted in a water bath at 50°C for 5-7h, neutralized with acetic acid or hydrochloric acid to a pH of 6.0-7.0, washed with an appropriate amount of methanol, suction filtered, and dried at 50°C. Trehalose quaternary ammonium salt was obtained.

Embodiment 3

[0022] The difference from Example 1 is:

[0023] Preparation of trehalose quaternary ammonium salt: add 1g trehalose to 15mL isopropanol, then add 0.35g NaCl (5%) to prevent swelling, adjust pH=11 with NaOH, add etherification agent 2,3-epoxypropyl trimethyl ammonium chloride (25%) 11.94mL, stirred and reacted in a water bath at 60°C for 3-5h, neutralized with acetic acid or hydrochloric acid to a pH of 6.0-7.0, washed with an appropriate amount of methanol, suction filtered, and dried at 50°C to obtain seaweed Sugar quaternary ammonium salt.

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Abstract

The invention relates to a moisture absorption humectant which adopts trehalose quaternary ammonium salt and a preparation method thereof, belonging to the daily chemical field and medicine industry. The moisture absorption humectant adopts trehalose quaternary ammonium salt as a moisture absorption moisturizing agent. The preparation method is as follows: the trehalose quaternary ammonium salt is prepared by the method that trehalose, whose mole mass ratio is 1: 4 to 6, is processed by alkaline isopropanol solution, then the trehalose reacts with an etherifying agent for 3 to 9 hours under 40 DEG C to 60 DEG C, and finally, the trehalose is air pump filtered and dried; and the etherifying agent is 3-chlorine-2- hydroxypropyl trimethyl ammonium chloride. The moisture absorption humectant adopts effective synthesizing means to prepare the trehalose quaternary ammonium salt, so the production cost is improved little while the moisture absorption and moisture retention performances are improved obviously. As an effective moisture absorption and moisture retention factor, the prepared trehalose quaternary ammonium salt is hopeful to become a substitute of hyaluronic acid to be used inthe cosmetics.

Description

technical field [0001] The invention relates to the field of daily chemicals and the pharmaceutical industry, in particular to a hygroscopic moisturizing agent using trehalose quaternary ammonium salt and a preparation method thereof. Background technique [0002] Hyaluronic acid (Hyaluronic acid), also known as hyaluronic acid, is an acidic polymucopolysaccharide. It has strong hydrophilicity and very good moisturizing performance. It is the best moisturizing substance found in nature. Cosmetics industry is recognized as the most ideal natural moisturizing factor. However, the source of hyaluronic acid is very limited, and the extraction cost is high, which makes hyaluronic acid expensive and unable to meet market needs. Finding suitable substitutes is one of the effective channels to solve the lack of hyaluronic acid. [0003] Trehalose, also known as yeast sugar, is a non-reducing disaccharide formed by condensation of two α-D glucose molecules through hemiacetal groups...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H3/04A61K8/60
Inventor 郭占勇杨少丽薛钦昭王刚苗凤萍衣悦涛王艳
Owner 烟台大境生物科技有限公司
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