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Ibuprofen suspension and method of preparing the same

A suspension and suspending agent technology, applied in the field of medicine, can solve the problems of affecting the therapeutic effect, difficulty in accurately controlling the dosage, and children's reluctance to actively take it, and achieve the effects of good compliance, easy storage, and easy production and operation

Inactive Publication Date: 2009-01-21
扬州市三药制药有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Most of the antipyretic and analgesic drugs with ibuprofen as the active ingredient in the market are solid preparations. Children need to divide a tablet or a pill into several doses to take. The dosage is difficult to control accurately. Secondly, it has a spicy taste of the drug. Children are unwilling to take it actively, which greatly affects the therapeutic effect

Method used

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  • Ibuprofen suspension and method of preparing the same

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Embodiment Construction

[0026] 1. The ratio of raw materials:

[0027] In 1000ml product, the content of each cube is:

[0028] Ibuprofen 25.0g Polytrilyte-80 4.0g

[0029] Sodium carboxymethyl cellulose 3.75g glycerin 100g

[0030] Hydroxypropyl methylcellulose 3.75g Hydroxypropyl cellulose 3.0g

[0031] Stevioside 1.8g Disodium ethylenediaminetetraacetic acid 0.5g

[0032] Carmine (color) 0.1g flavor 10g

[0033] Sucrose 500g Sodium Benzoate 3.0g

[0034] 2. Process steps:

[0035] 1. Make simple syrup

[0036] Add sucrose to boiling purified water, stir until it is completely dissolved, add an appropriate amount of preservative sodium benzoate, keep it warm for 50 minutes, and filter for use.

[0037] 2. Moist

[0038] Add ibuprofen with a particle size of ≤2μm to the wetting agent polytrilyte-80, stir well for 15 minutes and then leave it for 24 hours.

[0039] 3. Swelling

[0040] Swell the suspending agent sodium carboxymethyl cellulose and hydroxypropyl methyl cellulose in purified water with an a...

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Abstract

An ibuprofen suspension and a preparation method thereof relate to medicines, in particular to the pharmaceutical technical field of chemical drugs. The preparation method comprises the following steps: sucrose and an antiseptic are mixed with purified water to produce simple syrup, the ibuprofen is moistened in a moistening agent; suspending agents are respectively swelled; then the three mixtures are mixed and ground with glycerol, a deflocculating agent and the purified water to produce grinding liquid; the grinding liquid, the simple syrup, the antiseptic and a corrective agent are added into a liquid preparation tank and stirred evenly, thus the ibuprofen suspension is obtained. The ibuprofen suspension and the preparation method thereof have the advantages of simple process, being easy for manufacturing and operation, high qualification rate of the finished product, good drug effect and being easy for storage; the ibuprofen suspension has no spicy taste, is convenient to be taken by children, and can be directly absorbed by human body without disintegration and dissolution, thus the drug can be absorbed quickly and has quick effect.

Description

Technical field [0001] The present invention relates to medicine, especially the pharmaceutical technology field of chemical medicine. Background technique [0002] At present, most antipyretic and analgesic drugs with ibuprofen as the active ingredient on the market are solid preparations. For children, it is necessary to divide one tablet or one drug into several portions, which is difficult to accurately control the dosage. Secondly, it has the pungent taste of the drug. Children are unwilling to take the initiative, which greatly affects the treatment effect. Summary of the invention [0003] The purpose of the present invention is to invent an oral suspension of ibuprofen for children that has no pungent taste and is convenient for children to take. [0004] In addition to the active ingredient containing ibuprofen, the present invention also includes suspending agent, glycerin, wetting agent, deflocculant and flavoring agent. [0005] The function and effect characteristic...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/192A61P29/00
Inventor 解家顺祝瑞章
Owner 扬州市三药制药有限公司
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