Use of Mosla non-volatile extract in preparing anti-influenza medicine

A non-volatile, influenza virus technology, applied in antiviral agents, pharmaceutical formulations, plant raw materials, etc.

Inactive Publication Date: 2009-02-11
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report that the non-volatile extract of Camelina chinensis has the medi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Preparation of non-volatile extract of Camelina chinensis

[0019] Take 1000g of medicinal material Mosla hangchowensis Matsuda, grind or cut into small pieces, add 20 times of 70% (v / v) ethanol solution, extract at 70°C for 2h, and concentrate to obtain 283g of extract (yield 28.3 %), the extract is extracted with 1800-2400 mL of ethyl acetate until the hydrochloric acid-magnesium powder reaction is weakly positive or negative [add a little magnesium powder to the ethanol or methanol solution of the extract and shake, then add a few drops of concentrated hydrochloric acid, 1 ~2 minutes (heating on a water bath if necessary) will show red to purple red, then the reaction will be shown as positive, and if there is no color reaction, then it will be shown as negative]. That is the non-volatile extract of ramie ramie, wherein the total flavonoid content of ramie ramie is 50.1%, and the yield is 3.9%.

[0020] chemically separated, 13 C. 1 H-NMR measurement...

Embodiment 2

[0021] Example 2: Experimental research on anti-influenza virus of non-volatile extract of Camelina chinensis

[0022] Take 18-22g ICR mice (provided by Shanghai Experimental Animal Center of Chinese Academy of Sciences / Shanghai Slack Experimental Animal Co., Ltd.), and set up normal control group, virus model group, Tamiflu control group (0.02g / kg) and extract Low dose group (2g crude drug / kg, i.e. 0.15g embodiment 1 extract / kg), middle dose group (4g crude drug / kg, i.e. 0.3g embodiment 1 extract / kg), high dose group (6g crude drug / kg , namely 0.45g embodiment 1 extract / kg). Each group was pre-administered by intragastric administration for 3 days before the challenge, at a rate of 0.2 mL / 10 g of mouse body weight, and continued to administer until the end of the experiment. On the third day, 2 hours after the administration, under light ether anesthesia, the mouse lung-adapted strain A / PR / 8 / 34 of influenza A virus (provided by the Zhejiang Provincial Center for Disease Cont...

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PUM

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Abstract

The invention provides the application of a mosla non-volatile extraction in preparing medicines for preventing influenza virus. The active ingredients of the mosla non-volatile extraction are ursolic acid, mosla flavones I, mosla flavones II, apigenin, acacetin and the like. Verified by an animal model test, the mosla non-volatile extraction has relatively strong effect on resisting influenza virus and provides basis for the development of new medicines.

Description

(1) Technical field [0001] The invention relates to the application of the non-volatile extract of ramie ramie in the preparation of anti-influenza virus medicine. (2) Background technology [0002] Influenza is a common infectious disease caused by influenza virus infection that seriously endangers human health. At present, the clinically used drugs are mainly western medicines, such as ribavirin, Zimbavirin, ribavirin and so on. Chinese herbal medicine has played an important role in the prevention and treatment of influenza (especially during the SARS period). It has unique advantages and broad development prospects in the prevention and treatment of influenza. [0003] Lamiaceae is an annual herbaceous plant. It is widely distributed in my country and rich in resources. It is a commonly used Chinese herbal medicine in Jiangsu and Zhejiang. Ramie and so on. According to "Zhejiang Folk Commonly Used Herbs", it is warm in nature, slightly pungent, and enters the lung and...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P31/16
Inventor 吴巧凤熊耀康严云良余陈欢俞冰黄家卫吕佩惠盛振华上官海燕文欣欣
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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