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Method for preparing environmental responsibility mesoporous silicon sphere

An environmentally responsive, mesoporous silicon sphere technology, which is used in medical preparations and pharmaceutical formulations with non-active ingredients, can solve the problems of blocking mesoporous channels and ineffective drug release, and achieves a wide range of applications.

Inactive Publication Date: 2012-05-23
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] As far as the environment-responsive mesoporous silica spheres are concerned, there are relatively few reports in the literature, and the atom group transfer polymerization (ATRP) method is mainly used to modify polymers on mesoporous spheres. One problem with this method is that the modified polymers are in The chain segment shrinks at high temperature, which easily blocks the mesoporous channels and cannot effectively achieve drug release

Method used

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  • Method for preparing environmental responsibility mesoporous silicon sphere
  • Method for preparing environmental responsibility mesoporous silicon sphere
  • Method for preparing environmental responsibility mesoporous silicon sphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: With the oil phase iron ferric oxide nanoparticles as the core, hexadecyltrimethylammonium bromide is the template agent, and the magnetic mesoporous spheres (aperture 3.1nm, size 170 ± 20nm), such as figure 1 The transmission electron micrograph of the magnetic mesoporous sphere is shown. Disperse 100 mg of magnetic mesoporous spheres without template removal in ethanol, add 3-trimethoxysilyl propyl methacrylate (MPS) at 80-85°C to modify the surface with double bonds, MPS and magnetic mesoporous spheres The mass ratio is 1:1~2:1. After reacting for 3~5h, the unreacted MPS is removed by centrifugation, and the product is dispersed in 20mL ammonium nitrate ethanol solution (10mg / mL), at 80~85℃ React for at least 6h to remove template agent. Purify the product by centrifugation, disperse in water, add N-isopropylacrylamide (NIPAM) 900mg, N-methylolacrylamide (NHMA) 100mg, N,N'-methylenebisacrylamide (MBA ) 50 mg, after ultrasonic dispersion was sufficien...

Embodiment 2

[0020] Embodiment 2: With the oil phase iron ferric oxide nanoparticles as the core, hexadecyltrimethylammonium bromide is the template agent, and the magnetic mesoporous spheres (aperture 3.1nm, size 170 ± 20nm). Disperse 100 mg of magnetic mesoporous spheres without template removal in ethanol, add 3-trimethoxysilyl propyl methacrylate (MPS) at 80-85°C to modify the surface with double bonds, MPS and magnetic mesoporous spheres The mass ratio is 1:1~2:1. After reacting for 3~5h, the unreacted MPS is removed by centrifugation, and the product is dispersed in 20mL ammonium nitrate ethanol solution (10mg / mL), at 80~85℃ React for at least 6h to remove template agent. Purify the product by centrifugation, disperse in water, add 850 mg of N-isopropylacrylamide (NIPAM), 150 mg of N-methylolacrylamide (NHMA), N, N'-methylenebisacrylamide (MBA ) 50 mg, after ultrasonic dispersion was sufficient, 30 mg of potassium persulfate (KPS) was added, and reacted at 75° C. for 6 h under nitr...

Embodiment 3

[0021] Embodiment 3: With the oil phase iron ferric oxide nanoparticles as the core, hexadecyltrimethylammonium bromide is the template agent, and the magnetic mesoporous spheres (aperture 3.1nm, size 170 ± 20nm). Disperse 100 mg of magnetic mesoporous spheres without template removal in ethanol, add 3-trimethoxysilyl propyl methacrylate (MPS) at 80-85°C to modify the surface with double bonds, MPS and magnetic mesoporous spheres The mass ratio is 1:1~2:1. After reacting for 3~5h, the unreacted MPS is removed by centrifugation, and the product is dispersed in 20mL ammonium nitrate ethanol solution (10mg / mL), at 80~85℃ React for at least 6h to remove template agent. Purify the product by centrifugation, disperse in water, add N-isopropylacrylamide (NIPAM) 800mg, N-methylolacrylamide (NHMA) 200mg, N,N'-methylenebisacrylamide (MBA ) 50 mg, after ultrasonic dispersion was sufficient, 30 mg of potassium persulfate (KPS) was added, and reacted at 75° C. for 6 h under nitrogen atmo...

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Abstract

The invention relates to a method for preparing an environmental responsibility meso-pore silicone bead. The method comprises the following steps: firstly taking oil phase ferroferric oxide nanometer particles as a core, taking hexadecyl trimethyl ammonia bromide as a template agent, and obtaining the magnetic meso-pore bead with the aperture of 3.1 nanometers and the size of between 150 and 190 nanometers through a sol-gel reaction; then carrying out the surface activation treatment on the magnetic meso-pore bead; and finally, polymerizing environmental responsibility polymers deposited on the surface of the magnetic meso-pore bead through a template to obtain the magnetic meso-pore bead the surface of which is decorated with temperature sensibility polymers. The method is simple, the raw materials are easily available, and the preparation amount is large. The environmental responsibility meso-pore bead can regulate the phase transition temperature of the polymers through controllingthe mixture ratio of different polymers. The product obtained through the method has bright application prospect in the field of effectively controlled medicine release.

Description

Technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for preparing an environment-responsive mesoporous silicon sphere. technical background [0002] Mesoporous silica spheres are porous molecular sieves with uniform pores and adjustable pore diameters prepared by nano-self-assembly technology. The pore diameters are generally between 2 and 50 nanometers. Due to the characteristics of large specific surface area, adjustable pore size, uniform pore size, and easy surface modification, mesoporous materials are widely used in the fields of catalysis, separation, and sensors. Due to the non-toxicity and good biocompatibility of silica spheres, microspheres with porous structure are widely used in the fields of drug loading and drug release. However, when mesoporous silica spheres are used for drug loading, they have certain disadvantages for the fixed-point release and bioseparation of encapsulated drugs...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F292/00C08F220/54C08F2/16A61K47/32
Inventor 杨武利刘聪颖
Owner FUDAN UNIV