Silicon dioxide magnetic composite particle and preparation

A technology of silica and composite particles, which is applied in the field of magnetic materials, can solve the problems of small specific surface area and large particle size, and achieve the effect of large specific surface area, low equipment requirements and easy control of conditions

Active Publication Date: 2009-03-18
长春市博坤生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large particle size and small specific surface area, the adsorption activity and adsorption capacity are significantly lower than those of nano-sized particles.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: 200nm γ-Fe 2 o 3 — Preparation of silica magnetic composite particles

[0017] Synthesis of 15nm γ-Fe by published method 2 o 3 — For silica core-shell nanoparticles, mix 700ml of water and 300ml of ethanol, add 4.0g of sodium chloride and 1.0g of pentamethylenediamine, stir to dissolve, then add 2.0g of 15nm γ-Fe 2 o 3—Silicon dioxide core-shell nanoparticles were reacted for 15 minutes at a stirring speed of 150 rpm. Then, 20 ml of concentrated ammonia water with a mass percent concentration of 25-28% was added to the solution, and 0.1 ml of tetraethyl orthosilicate was added dropwise at a stirring speed of 400 rpm for 5 hours of reaction. Use a permanent magnet to separate the solid from the reaction solution, and wash the solid with high-purity water for 3 times to obtain γ-Fe 2 o 3 - Silica magnetic composite particles, the average size of which is 200nm.

Embodiment 2

[0018] Example 2: 600nm Fe 3 o 4 — Preparation of silica magnetic composite particles

[0019] 30nm Fe was synthesized by the method reported in the literature 3 o 4 - Silica core-shell nanoparticles. After mixing 500ml of water and 500ml of propanol, add 50.0g of aluminum chloride and 2.0g of tetraethylenepentamine, stir and dissolve, then add 5.0g of 30nm Fe 3 o 4 —Silicon dioxide core-shell nanoparticles were reacted for 15 minutes at a stirring speed of 50 rpm. Then, 30 ml of concentrated ammonia water with a mass percent concentration of 25-28% was added to the solution, and at a stirring speed of 300 rpm, 0.2 ml of tetraethyl orthosilicate was added dropwise and reacted for 12 hours. Use a permanent magnet to separate the solid from the reaction solution, and wash the resulting solid 3 times with high-purity water to obtain Fe 3 o 4 - Silica magnetic composite particles, the average size of which is 600nm.

Embodiment 3

[0020] Example 3: 1 μm Co 3 o 4 — Preparation of silica magnetic composite particles

[0021] 50nm Co was synthesized by the method reported in the literature 3 o 4 - Silica core-shell nanoparticles. After mixing 300ml of water and 700ml of methanol, add 15.0g of magnesium nitrate and 2.0g of polyethylene diamine, stir to dissolve, add 12g of 50nmCo 3 o 4 —Silicon dioxide core-shell nanoparticles, reacted for 30 minutes under the condition that the stirring speed was 80 rpm. Then, 40 ml of concentrated ammonia water with a mass percent concentration of 25-28% was added to the solution, and 0.35 ml of tetraethyl orthosilicate was added dropwise at a stirring speed of 300 rpm for 8 hours of reaction. Use a permanent magnet to separate the solid from the reaction solution, and wash the resulting solid with high-purity water for 3 times to obtain Co 3 o 4 - Silica magnetic composite particles with an average size of 1 μm.

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Abstract

The invention belongs to the field of magnetic materials, in particular to a silicon dioxide magnetic composite particle and a method for preparation. Ferrite-silicon dioxide core-shell nano particles are dispersed to alcohol-water mixed solvent, inorganic salt and organic cross-linking agent are added, then ammonia and a little silicon source are added to solution, thereby forming a steady cross bonding body. During the process of preparation, the size and the specific surface of the silicon dioxide magnetic composite particles can be controlled and formed through changing the size and the concentration of the ferrite-silicon dioxide core-shell nano particles, the concentration of inorganic salt, the concentration of the organic cross-linking agent and the addition of the silicon source. The surface of the particle is equipped with small-sized nanometer processes, the specific surface area thereof is bigger, the adsorption activity is stronger, and the adsorption capacity is also bigger. The silicon dioxide magnetic composite particle and the method for preparation are very suitable for separation, purification, marking and detection of various biological materials and medical products. The method for preparation has simple technical process, has low requirements for equipment, is easy to control conditions, and is easy to achieve batch production.

Description

technical field [0001] The invention belongs to the field of magnetic materials, in particular to a novel silicon dioxide magnetic composite particle and a preparation method thereof. Background technique [0002] Ferrite nanoparticles with superparamagnetism are widely used in biological and medical fields such as separation and purification of biological materials, biomolecular labeling and immunodetection. Due to the strong magnetic dipole interaction between ferrite nanoparticles, it is easy to form large aggregates, and the chemical stability of pure ferrite nanoparticles is poor, easy to oxidize and dissolve under acidic conditions, so the specific application When it is used, it is often necessary to combine ferrite nanoparticles with organic materials or inorganic materials to form magnetic composite particles to improve the dispersibility and chemical stability of the particles. In recent years, the use of inorganic silica to composite ferrite nanoparticles has att...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/11B22F1/02
Inventor 王刚杨百全董涛胡海吴晓明
Owner 长春市博坤生物科技有限公司
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