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Multi-cavity composite micro/nano capsule and preparation method and device thereof

A nanocapsule and nanosphere technology, which is applied in the preparation and application of micro-nano materials, can solve the problem that composite particles do not have core-shell structure and sub-cavity structure, it is difficult to avoid mutual diffusion, mutual reaction, and it is not suitable for precise control of processing and preparation, etc. problem, to achieve the effect of independent coating

Inactive Publication Date: 2009-03-25
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this composite particle does not have a core-shell structure and a sub-cavity structure, that is, there is no separation layer between each component and each component and the external environment, and it is difficult to avoid mutual diffusion and mutual reaction between the components. It is suitable for the processing and preparation of environmentally sensitive materials, reactive materials and precise control of the distribution of composite components

Method used

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  • Multi-cavity composite micro/nano capsule and preparation method and device thereof
  • Multi-cavity composite micro/nano capsule and preparation method and device thereof
  • Multi-cavity composite micro/nano capsule and preparation method and device thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0062] See figure 1 . use as figure 1 The shown device prepares multi-cavity composite micro / nanocapsules, and the device is composed of an outer nozzle 2 and two inner nozzles 3. A multi-fluid composite nozzle 1, a high-voltage electrostatic generator 4, a ground wire 5, and a static flat metal plate ( or coagulation bath) as a collection plate 6, a liquid storage tank 7, a liquid supply pump 8, an infusion pipeline 9 and the like.

[0063] The outer fluid contained in the liquid storage tank 7 is delivered to the outer spray pipe 2 at a certain flow rate through the liquid supply pump 8 and the infusion tube 9; similarly, the inner fluid is delivered to the inner spray tube at a certain flow rate through the liquid supply pump and the infusion tube. Tube 3; the inner and outer fluids meet at the nozzle of the composite nozzle to form a composite fluid. The inner and outer nozzles are made of metal materials and connected to the positive pole of the high-voltage electrosta...

Embodiment 2

[0067] The device of Example 1 was used.

[0068] 2.0 g of polycaprolactone was dissolved in 8 g of chloroform and ethanol mixture (2 / 1, w / w) as the external fluid. The external fluid is passed through the liquid supply pump and the infusion tube at a rate of 1.0-5.0mL·h -1 The velocity is delivered to the outer nozzle. Dissolve 2.5g polyethylene glycol in 6.5g deionized water, then add it to 0.1g acetylsalicylic acid in 0.9g ethanol solution as internal fluid 1; dissolve 2.5g polyethylene glycol in 7.4g deionized Add 0.1g of penicillin to the water as the internal fluid 2, and inject 0.1-1mL·h through the liquid supply pump and infusion tube -1 The velocity of the inner fluid 1 and the inner fluid 2 are delivered to the two inner nozzles respectively. Composite EFI was performed using the same conditions as described in Example 1. A functional microcapsule with a layer of polycaprolactone as the shell material and two drug components loaded in two cavities can be obtained...

Embodiment 3

[0071] The device of Example 1 was used.

[0072] 2.0 g of polymethyl methacrylate was dissolved in 8.0 g of N,N-dimethylformamide as an external fluid. The external fluid is passed through the liquid supply pump and the infusion tube at a rate of 1.0-5.0mL·h -1 The velocity is delivered to the outer nozzle. Dissolve 0.5mg of rhodamine B in 5g of ethylene glycol as internal fluid 1, and dissolve 0.5mg of fluorescein isothiocyanate in 5g of ethylene glycol as internal fluid 2. h -1 The velocity of the inner fluid 1 and the inner fluid 2 are delivered to the two inner nozzles respectively. The composite nozzle is connected to the positive electrode of the high-voltage electrostatic generator, and the metal plate covered with aluminum foil is grounded and used as a collecting plate. The working voltage is 15-25KV, and the distance between the composite nozzle and the collecting plate is 35cm. After multi-fluid compound electrospraying, the functional microcapsules with polyme...

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Abstract

The invention belongs to the field of micron-nanometer material preparation and application, more particular relates to a multi-cavity composite micron / nanometer capsule and a multi-cavity micron / nanometer ball as well as the preparation method and device thereof. The multi-cavity composite micron / nanometer capsule is of a ball structure with micron and nanometer size, a plurality of cavities are arranged inside the ball, and the number of the cavities can be controlled; the cavities are separated and mutually independent by inner walls made of shell material; the cavities can respectively load different nuclear materials or same nuclear material, and the variety, the number and the distribution in the ball can be accurately controlled; the nuclear materials are mutually independent, do not contact mutually and do not contact with the outside environment directly; the shell material which forms the multi-cavity composite micron / nanometer capsule is different from the nuclear material; and the nuclear materials are selectively removed to obtain the micron / nanometer structure with multiple cavities. The preparation method is a multiple-fluid composite electric injection method, and the device has the characteristic that a multiple-fluid composite spray head is adopted. The multi-cavity micron / nanometer capsule provided by the invention is applied to coatings for environment sensitive materials and reactive materials, and the like.

Description

technical field [0001] The invention belongs to the field of preparation and application of micro-nano materials, in particular to multi-cavity composite micro / nano capsules, multi-cavity micro / nano balls and their preparation methods and devices. Background technique [0002] In recent years, micro / nanocapsules with a core-shell structure have broad application prospects in the fields of pharmaceuticals, food industry, cosmetics, and catalysts. Compared with ordinary particles, micro / nanocapsules have the following advantages: the shell material separates the coated material from the external environment, which can protect the environmentally sensitive or easily decomposed coated material, reduce the toxicity, odor, and modification of the coated material. The nature of the coated material, etc., has received widespread attention. Many effective methods for preparing micro / nanocapsules have been proposed, such as microfluidic technology, template method, emulsification met...

Claims

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Application Information

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IPC IPC(8): B01J13/04
Inventor 陈洪燕赵勇江雷
Owner INST OF CHEM CHINESE ACAD OF SCI
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