Swertia diluta extract and preparation method and use thereof

A medicinal extract and extract technology are applied in the field of medicinal extract and its preparation and application, which can solve the problems of difficulty in extraction and purification, few literatures, and weak functional group specificity, so as to improve the curative effect of medicine, easy to operate, and reliable. Strong implementation effect

Inactive Publication Date: 2009-04-01
BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Modern pharmacological experiments have shown that split iridoids such as swertiamarin in the drug are chemical components related to hepatoprotective activity, but due to the lack of specificity of functional groups in the st

Method used

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  • Swertia diluta extract and preparation method and use thereof
  • Swertia diluta extract and preparation method and use thereof
  • Swertia diluta extract and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 10Kg of medicinal materials, cut them into pieces by 2-5 cm, add 120L of water, soak for 1 hour, reflux extraction for 1 hour, filter; add 100L of water to the dregs, reflux extraction for 1 hour, filter, and extract the dregs once more in the same way. Combine the filtrates, concentrate until the volume ratio of the medicinal solution to the medicinal material is 2:1, and centrifuge at 4000rpm for 10min. Get the supernatant and add it to the processed HPD300 (Cangzhou Baoen Chemical Co., Ltd.) macroporous adsorption resin column (the volume of the resin bed is about 33L, which is equivalent to the weight ratio of dry resin and medicinal material being 0.75:1, and the diameter-to-height ratio 1:7), first use 3 times the volume of the resin bed (3BV) for water elution to almost colorless, discard the eluent, and then elute with 25% aqueous ethanol, collect 1 part per 7500ml, collect 16 parts (equivalent to about 4BV), test, according to the test results, decide to c...

Embodiment 2

[0023] Take 6Kg of the medicinal material, crush it properly, add 72L of water, soak for 1 hour, reflux for 1 hour, filter; add 60L of water to the dregs, reflux for 1 hour, filter, extract the dregs again in the same way, combine the filtrate, and concentrate Until the volume of the medicinal liquid and the mass ratio of the medicinal material are 2:1, filter, get the filtrate, and add it to the processed HPD100 (Cangzhou Baoen Chemical Co., Ltd.) type macroporous adsorption resin column (resin bed volume 24L, which is equivalent to dry resin and The weight ratio of the medicinal material is 0.9:1, and the diameter-to-height ratio is 1:5), first wash and elute with water twice the resin bed volume (2BV), discard the eluent, and then elute with 40% ethanol aqueous solution, Collect 1 fraction per 6000ml, collect up to 16 fractions (equivalent to about 4BV), test, decide to combine the 2nd to 13th fractions of eluents according to the test results, and recover ethanol under redu...

Embodiment 3

[0026] Take 2Kg of medicinal materials, cut into pieces 2-5 cm, add 24L of water, soak for 1 hour, reflux extraction for 1 hour, filter; add 20L of water to the dregs, reflux extraction for 1 hour, filter, and extract the dregs once more in the same way, Combine the filtrates, concentrate until the volume of the medicinal liquid and the mass ratio of the medicinal materials are 2:1 (v / w), filter, take the filtrate, and add it to the D101 (Tianjin Haiguang Chemical Co., Ltd.) type macroporous adsorption resin column (resin Bed volume 6L, equivalent to the weight ratio of dry resin and medicinal material is 0.6: 1, the ratio of diameter to height is 1: 6), first use 4 times of resin bed volume (4BV) water elution, discard eluent, Then elute with 60% ethanol aqueous solution, collect 1 part per 1500ml, collect to 16 parts (equivalent to about 4BV), detect, and decide to combine the 2nd to 12th eluents according to the test results, and recover ethanol under reduced pressure at 60°...

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Abstract

The invention relates to a false Chinese swertia herb extract, a preparation method and an application thereof. The method takes false Chinese swertia herb as raw material, and the false Chinese swertia herb extract which contains more than 50 percent of secoiridoid compounds, more than 40 percent of single ingredient of swertiamain and more than 45 percent of three ingredients of chiratin, gentiopicroside, and the like, is obtained by using only one step of the macroporous absorption resin purification process after the extraction. The extract has significant effects on the protection, the prevention and the treatment of liver injury. The product has simple method and operation, high product yield, good repeatability and strong feasibility.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine extract and its preparation method and application, in particular to the medicinal extract, its preparation method and the application of the extract in medicines for protecting, preventing and treating liver damage. Background technique [0002] Liver damage is the result of various liver diseases. Many factors, such as viruses, organisms, drugs, physical chemistry, alcohol, etc., can cause liver damage. The study of liver injury in modern medicine is relatively in-depth. The mechanism of liver injury has been explored from many aspects, and liver protection drugs such as membrane protective agents, anti-lipid peroxidation agents, and anti-immune reaction agents have been developed, but the curative effect is still difficult. Satisfactory, and because of its toxic and side effects, the clinical application is limited. [0003] The extraction and separation of active components of traditi...

Claims

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Application Information

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IPC IPC(8): A61K36/51A61P1/16
Inventor 叶祖光黄文哲
Owner BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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