Method for preparing Cydiodine lozenge and Cydiodine lozenge

A technology of cedi iodine and weight percentage content, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulas, active ingredients of iodine compounds, etc., can solve serious environmental pollution, difficult implementation of industrial production, and stability of cedi iodine buccal tablets To improve the dissolution rate, overcome the easy sublimation and improve the stability

Inactive Publication Date: 2009-04-22
北京华素制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] An object of the present invention is to provide a stable, easy-to-implement, and non-environmentally polluting Sidi iodine-containing lozenge to solve problems such as poor stability of the prior art Sidi iodine lozenges, difficult implementation of industrial production, and serious environmental pollution. The preparation method of tablet and cediodine buccal tablet

Method used

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  • Method for preparing Cydiodine lozenge and Cydiodine lozenge
  • Method for preparing Cydiodine lozenge and Cydiodine lozenge
  • Method for preparing Cydiodine lozenge and Cydiodine lozenge

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Embodiment 1

[0050] The preparation of embodiment 1 cediodine

[0051] Put 30L55% ethanol solution or water into the reaction tank, add I 2 1kg, other auxiliary materials according to KI:I 2 : β-CD=1:1:1 (molar ratio) added, KI, I 2 Stir to make it completely dissolve, then add β-CD to rise to 85°C, reflux for 2 hours, release the mixed solution into a stainless steel bucket after cooling fully, and filter with a centrifuge to obtain a brown solid, which is removed from the filter bag of the centrifuge Take it out, dry it and crush it for later use.

Embodiment 2

[0052] The preparation of embodiment 2 cedicephalus

[0053] Put 30L of 55% ethanol solution or water into a reaction tank, heat it, add 5.0Kg of β-cyclodextrin, add 2kg of menthol under stirring, stir at a constant temperature of 60°C for 1 hour, discharge the material, and filter it with a centrifuge to obtain white Solid, the solid is taken out from the filter bag of the centrifuge, dried, sealed and stored for later use.

Embodiment 3

[0054] The preparation of embodiment 3 cediodine buccal tablets

[0055] 1. Prescription of cediodine lozenges

[0056] Name of raw material Specification Dosage (%) cediiodine Medicinal 3 Sidi Brain Medicinal 10 sucrose edible 82 Hydroxypropyl Methyl Cellulose

white Medicinal

3

Magnesium stearate Medicinal 2

[0057] 2. Add the prescribed amount of powdered sugar and cediodine into the wet mixing granulator, dry mix for 50 seconds, add hydroxypropyl methylcellulose aqueous solution, wet mix for 50 seconds, and discharge to obtain soft material. The prepared soft material is granulated through a 20-mesh sieve, and then dried.

[0058] 3. Add the dry granules together with the prescribed amount of magnesium stearate and cedibranch into the mixing tank, and mix for 2 minutes.

[0059] 4. Compress the above granules into tablets to obtain cediodine buccal tablets.

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Abstract

The invention relates to the field of cydiodine product, in particular to a preparation method for a cydiodine buccal tablet and the cydiodine buccal tablet. The invention solves the problems that the cydiodine buccal tablet in the prior art has poor stability and serious environmental pollution, is not easy to implement industrial production, and the like, and provides a preparation method for a stable cydiodine buccal tablet and the cydiodine buccal tablet. The method comprises the following steps: preparing cydiodine, that is, adding KI and I2 into a solvent, stirring the mixture for complete dissolution, adding beta-CD into the solvent, reacting, filtering, and obtaining a solid; preparing taste improving agent; and preparing the tablet. The cydiodine buccal tablet prepared by the method has the advantages that the cydiodine buccal tablet has good stability, is easy to implement, and does not cause environmental pollution.

Description

【Technical field】 [0001] The invention relates to the field of cediodine products, in particular to a preparation method of cediiodine buccal tablets and cediiodine buccal tablets. 【Background technique】 [0002] Oral diseases (oral ulcers, stomatitis, gingivitis, periodontitis, pericoronitis, etc.), throat diseases (acute and chronic pharyngitis, tonsillitis, etc.) Iodine (I 2 ) has been used as a disinfectant for more than 100 years. It has a non-selective killing effect on bacteria, fungi, and viruses, and it can be called a broad-spectrum high-efficiency fungicide. However, due to the poor stability of the physical and chemical properties of iodine itself, it has a strong odor and is highly irritating to the skin, oral cavity and throat mucous membranes. Therefore, the clinical application of iodine is limited. In the past, the most common dosage form used clinically was "Iodine Throat Syndrome Tablets". However, extensive clinical use and a large number of experimenta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K33/18A61K47/40A61K47/48A61P1/02A61K47/61
Inventor 裴莉肖文彬焦克芳韩晔张洪北高建华石庭森
Owner 北京华素制药股份有限公司
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