Pharmaceutical composition containing sympathomimetic amine salt and co-distillable additive

Abstract

A pharmaceutical composition is provided which contains a water soluble acid salt of a sympathomimetic amine, e.g., pseudoephedrine, and an additive, e.g., a volatile amine or other odorant, that is co-distillable, e.g., by steam distillation, with the sympathomimetic amine and / or its derivatives, e.g., its free base.

Description

technical field [0001] The present invention generally relates to pharmaceutical compositions comprising salts of sympathomimetic amines, wherein the amines are particularly difficult to isolate by distillation for use in illicit drug manufacture. Background technique [0002] As the name implies, sympathomimetic compounds exert biological effects similar to those produced by activation of the sympathetic nervous system. For example, the pharmaceutical compound pseudoephedrine acts as an indirect mimic by causing the release of norepinephrine from adrenergic nerve endings, thereby stimulating alpha- and beta-noradrenergic receptors, especially in blood vessels of the upper airway. Sympathetic agents. This in turn causes blood vessels to constrict and swollen tissue in the sinuses and nasal passages to shrink, making the compound useful as a decongestant. [0003] Despite the legitimate use of such sympathomimetic compounds, sympathomimetic compounds such as the ubiquitous ...

AI Technical Summary

Problems solved by technology

[0014] Although the various methods set forth above inhibit the isolation of sympathomimetic amines or otherwise inhibit illicit synthetic attempts, techniques have been developed to limit the effectiveness of these methods