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Compound slow release preparation of acetyl aminophenol, pseudoephedrine and dextromethorphan

A paracetamol, sustained-release preparation technology, applied in the field of medicine, can solve the problems of large fluctuations in blood drug concentration, easy to cause side effects, short half-life of dextromethorphan, etc. Concentration stabilization effect

Inactive Publication Date: 2009-12-09
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the short half-life of dextromethorphan, the general dose is 15-30 mg, which needs to be administered 3-4 times a day, and the blood concentration fluctuates greatly, which is likely to cause side effects

Method used

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  • Compound slow release preparation of acetyl aminophenol, pseudoephedrine and dextromethorphan
  • Compound slow release preparation of acetyl aminophenol, pseudoephedrine and dextromethorphan
  • Compound slow release preparation of acetyl aminophenol, pseudoephedrine and dextromethorphan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription:

[0021] Acetaminophen

250g

Pseudoephedrine hydrochloride

90g

Hypromellose K4M

6g

Hypromellose E5

60g

microcrystalline cellulose

36g

10% Povidone K 30 aqueous solution

Appropriate amount

[0022] Coating prescription:

[0023] Dextromethorphan Hydrobromide

30g

Ethyl cellulose

30g

ethanol

Add to 1000ml

[0024] Preparation:

[0025] (1) Preparation of granules: Hypromellose K4M and hydroxypropylmethylcellulose E5 microcrystalline cellulose were passed through 80-mesh sieve respectively, fully mixed with equal increment method, and then mixed with para-acetyl Aminophenol and pseudoephedrine hydrochloride mixed evenly, with 10% povidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are prepared through a 20-mesh sieve, dried at 60°C, granulated through a 20-mesh sieve, and set aside.

[0026] ...

Embodiment 2

[0036] prescription:

[0037] Acetaminophen

240g

Pseudoephedrine hydrochloride

50g

Hypromellose K4M

6g

Hypromellose E5

75g

microcrystalline cellulose

45g

10% Povidone K 30 aqueous solution

Appropriate amount

[0038] Coating prescription:

[0039] Pseudoephedrine hydrochloride

50g

Dextromethorphan Hydrobromide

20g

Cellulose acetate

70.5g

water

Appropriate amount until completely dissolved

[0040] Preparation:

[0041] (1) Preparation of granules: Hypromellose K4M, hydroxypropylmethylcellulose E5, and microcrystalline cellulose were passed through 80 mesh sieves respectively, fully mixed with the method of equal increments, and then mixed with the same amount of increments. Mix acetaminophen and pseudoephedrine hydrochloride evenly with 10% povidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are ...

Embodiment 3

[0053] prescription:

[0054] Acetaminophen

250g

pseudoephedrine sulfate

40g

Dextromethorphan Hydrobromide

20g

Hypromellose K100M

10g

Hydroxyethyl cellulose

72g

microcrystalline cellulose

50g

10% Povidone K 30 aqueous solution

Appropriate amount

[0055] Coating prescription:

[0056] pseudoephedrine sulfate

50g

Dextromethorphan Hydrobromide

10g

Cellulose diacetate

35g

ethanol

Appropriate amount until completely dissolved

[0057] Preparation:

[0058] (1) Preparation of granules: Hypromellose K100M, hydroxyethyl cellulose, and microcrystalline cellulose are passed through 80-mesh sieves respectively, fully mixed with equal increments, and then mixed with para-acetamide in equal increments. Phenol, dextromethorphan hydrobromide and pseudoephedrine sulfate were mixed evenly, and mixed with 10% povidone K 30 The aqueo...

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PUM

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Abstract

The invention relates to a slow release preparation taking acetyl aminophenol, pseudoephedrine or physiologically acceptable slat thereof and dextromethorphan or physiologically acceptable slat thereof as active ingredients. The slow release preparation is characterized in that a releasing system comprises a tablet core and / or pill core capable of enabling a medicament to slowly release and a coating, wherein one part and / or all of the active ingredients exist in the tablet core and / or pill core, and the rest of the active ingredients exist in the coating.

Description

technical field [0001] The invention relates to a sustained-release preparation with acetaminophen, pseudoephedrine or a physiologically acceptable salt thereof and dextromethorphan or a physiologically acceptable salt thereof as active components, belonging to the field of medicine. Background technique [0002] A cold is an infection of the upper respiratory tract mucosa caused by many different types of viruses. The main symptoms are nasal congestion, sneezing, dry cough, mild sore throat, and fever. Systemic symptoms include general discomfort, headache, and muscle pain. Because there is no specific treatment at all, it is not necessary to make the virus firm, and only symptomatic treatment can be used to promote the relief of many symptoms of the cold. Since there is still no one drug to alleviate the coexisting symptoms, various compound preparations have been listed one after another. These compound preparations are composed of drugs with different curative effects t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/485A61K31/167A61K31/137A61K47/30A61P11/00A61P31/12
Inventor 李育巧郑顺利林鹏
Owner COSCI MED TECH CO LTD
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