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Alopecia prevention composition and production method thereof

A composition and the technology of the next group, applied in the field of traditional Chinese medicine, can solve the problems of small side effects and lack of curative effect

Inactive Publication Date: 2009-05-06
GREEN VALLEY GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although Chinese pharmacy has accumulated a lot of valuable experience for the prevention and treatment of hair loss, and has also developed a variety of traditional Chinese medicine hair loss prevention and treatment preparations, there is still a lack of hair loss prevention and treatment preparations with unique curative effect, overall regulation, and small side effects.

Method used

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  • Alopecia prevention composition and production method thereof
  • Alopecia prevention composition and production method thereof
  • Alopecia prevention composition and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1-8

[0156] Take the crude medicinal material of amount shown in table 4,

[0157] Table 4

[0158]

[0159] Wash, dry, and process the medicinal materials in the above weight ratio (prescription dosage 1 to 4) to coarse particles, mix them, add 10 times the amount (total weight of raw medicinal materials) of water and soak for 0.5 hours, heat and reflux for extraction 3 times, the first 4 hours for the first time, 3 hours for the second and third extractions respectively, filtered, combined, heated and concentrated the liquid extracts to a relative density of about 1.0-1.1 (60°C), and spray-dried to obtain brown-yellow powder samples 1-4.

[0160] (A) Preparation of spray

[0161] Dissolve the above extract powder samples 1 to 4 with water to a concentration of 0.5% (m / v), and add the prescribed amount of auxiliary materials polyoxyethylene, sodium thiosulfate, sodium lauryl sulfate and sodium benzoate, stir to fully dissolve, Filtrate, sub-package, respectively prepare spray...

Embodiment 9-16

[0165] According to the dosage ratio of the raw materials shown in Table 5, the method for preparing the extracts of formulas 1-4 was repeated to prepare the extracts of formulas 5-8, the difference was that the medicinal material mixture additionally contained peach kernels or Chuanxiong.

[0166] table 5

[0167]

[0168] With the method of embodiment 1-4, the sample of embodiment 5-8 is made spray e, f, g, h (respectively corresponding to embodiment 9,10,11 and 12) and gel e', f', g', h' (corresponding to Examples 13, 14, 15 and 16, respectively).

Embodiment 17

[0170] Animals: Wister rats, body weight 200-250 g, both male and female.

[0171] Reagent: The gel prepared in Example 5 (ie gel a') was diluted 1 time and concentrated 1 time respectively. Low, middle and high dose groups were obtained. Select blank group (negative sample preparation) and positive control group (Zhangguang 101 hair growth agent group) as comparison groups.

[0172] 1. The influence of the traditional Chinese medicine prescription of the present invention on the "scoring" of rat depilatory area body hair growth

[0173] Shorten the back hair of Wister rats, apply the depilatory agent (10% sodium sulfide) on the back of the rat for about 2 to 3 minutes, wash it with warm water, and take the back of the rat as smooth, without injury or residual hair as the net, the depilated area About 3×4cm. The next day, the rats were smeared with 75% ethanol, Zhangguang 101 hair growth agent, and the traditional Chinese medicine prescription of the present invention respe...

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PUM

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Abstract

The invention discloses a combination which can prevent or cure alopecia, and contains (a) carriers acceptable in pharmacy, and (b) effective quantity of water extracts or water organic solvent extracts of raw material medicines which are selected from angelica, tuber of multiflower knotweed, prepared rhizome of rehmannia, cacumen platycladi, angelica dahurica, tribulus terrestris, pangolin, etc. The invention also discloses a preparation method of the combination and the applications thereof in preventing and curing alopecia. The combination is prepared by pure natural components, thereby being safer and having little side effect.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine; more specifically, the invention relates to a composition containing extracts of Chinese herbal medicines, and the invention also relates to a preparation method and application of the composition. Background technique [0002] Hair loss, which is called "ghost shaved head" or "oil wind" in traditional Chinese medicine, is a common skin disease. Clinically, the main manifestations are large pieces of hair loss and thinning, and some patients are accompanied by loss of eyebrows and beards. Alopecia patients are often caused by certain factors that cause the hair to enter the resting phase of hair growth prematurely from the growth phase, the hair follicles and hair bulbs shrink, and the terminal hairs become fine vellus hairs. Alopecia is usually divided into seborrheic alopecia, alopecia areata etc., and seborrheic alopecia is the modal alopecia, accounts for more than 95% of alopecia...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K36/73A61K36/704A61K36/28A61K9/00A61K9/06A61K9/12A61P17/14A61K35/36
Inventor 陈海泉李素美
Owner GREEN VALLEY GROUP CO LTD
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