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Method for purifying ficus microcarpa leaf flavonoid compound with large-hole adsorption resin

A ficus leaf flavonoid and pore adsorption technology, applied in chemical instruments and methods, sugar derivatives, sugar derivatives and other directions, can solve the problems of low total flavonoid content, restricting drug efficacy, etc., and achieve no toxic side effects and significant economic benefits. and social benefits, the effect of low production costs

Inactive Publication Date: 2009-05-13
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the low content of total flavonoids, its efficacy is restricted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Accurately weigh 3.97g (filter paper blotted) pretreated DM130 macroporous adsorption resin in a 250ml Erlenmeyer flask; weigh 4.28g of Ficus microphylla water extract, add deionized water to dissolve, and let it stand for 6h to stratify once After filtration, the filter residue was dried and weighed, and the filtrate was adjusted to 50ml with water to obtain a sample stock solution with a mass concentration of 50.79mg / ml (the ratio of extract to deionized water was 1:20 (g / ml)). Add a few drops of 10% acetic acid aqueous solution to the original solution, adjust the pH of the original sample solution to 5.0, pipette 40ml of the original solution into a conical flask (the ratio of the amount of macroporous adsorption resin to the amount of adsorption solution is 1:10 (g / ml)), seal Put the mouth of the bottle into a constant temperature shaker to shake, the temperature is 0°C, the speed is 40rad / min, take out the adsorption solution after 24h; add 10ml of deionized water,...

Embodiment 2

[0027] Accurately weigh 4.21g (filter paper blotted) pretreated X-5 macroporous adsorption resin in a 250ml Erlenmeyer flask; weigh 0.84g of Ficus microphylla water extract, add deionized water to dissolve, let stand for 3h After one layer, filter, dry and weigh the filter residue, add water to the filtrate to 100ml, and obtain a sample stock solution with a mass concentration of 5.03mg / ml (the ratio of extract to deionized water is 1:200 (g / ml)). Add a few drops of 95% acetic acid aqueous solution to the original solution, adjust the pH to 1.0, pipette 80ml of the original solution into the Erlenmeyer flask (the ratio of the amount of macroporous adsorption resin to the amount of adsorption solution is 1:20 (g / ml)), seal the bottle mouth , placed in a constant temperature shaker to shake, the temperature is 80°C, the speed is 200rad / min, and the adsorption solution is taken out after 12 hours; 8ml of deionized water is added, shaken fully at room temperature for 6min, and the ...

Embodiment 3

[0029] Accurately weigh 4.52g (filter paper blotted) pretreated D101 macroporous adsorption resin in a 250ml Erlenmeyer flask; weigh 0.94g of Ficus microphylla water extract, add deionized water to dissolve, let stand for 3h and layer once After filtration, the filter residue was dried and weighed, and the filtrate was added with water to make up to 100ml to obtain a sample stock solution with a mass concentration of 5.53mg / ml (the ratio of extract to deionized water was 1:200 (g / ml)). Add a few drops of 95% acetic acid aqueous solution to the original solution, adjust the pH to 1.0, pipette 80ml of the original solution into the Erlenmeyer flask (the ratio of the amount of macroporous adsorption resin to the amount of adsorption solution is 1:20 (g / ml)), seal the bottle mouth , put into a constant temperature shaker and shake, the temperature is 80°C, the rotating speed is 200rad / min, take out the adsorption solution after 0.1h; add 8ml of deionized water, shake fully at room ...

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Abstract

The invention relates to a method for purifying folium fici microcarpae flavonoid compound by using macroporous absorbent resin technology. The purification method comprises the following steps: the aqueous extract extractum of the folium fici microcarpae is dissolved in deionized water, and is fully dissolved, and then the undissolved component is removed through pressure reducing and suction filtration; the PH value is adjusted to 1.0 to 10.0; the static adsorption and desorption in the bottle or the macroporous absorbent resin column dynamic adsorption is carried out, the eluting is carried out by using the ethanol-water combination, the eluent of each section is collected, and the folium fici microcarpae extractum with high-content flavone is obtained by pressure reducing and concentration. As for the folium fici microcarpae extractum produced by using the method, the content of the total flavone is more than 50 percent and is increased by more than three times than that of the prior folium fici microcarpae extractum, and the folium fici microcarpae extractum can be directly used as medicine. The invention has the advantages of low production cost, safety, non-toxicity, no side-effect and remarkable economic benefits.

Description

technical field [0001] The invention belongs to a method for purifying flavonoids from Ficus microphylla leaves by macroporous adsorption resin technology. Background technique [0002] Ficus microcarpa L.f. is a fig tree Ficus microcarpa L.f. of the family Moraceae. The leaves of Ficus xiaoye mainly contain flavonoids, triterpenoids, tannins, aliphatic compounds and steroidal compounds, etc., and its leaves are mainly used as medicine. Keteling Capsules, a drug for treating asthma and chronic bronchitis with its extract as the main component, has been collected in the Ministry Standards. Flavonoids and other active ingredients in the leaves of Ficus lobosa have significant effects on the treatment of coronary heart disease, senile dementia, cerebral thrombosis, nervous system diseases, elimination of free radicals, anti-inflammation, antibacterial, anti-cancer, etc., without toxic side effects, and In this way, various medicines and health food are developed. Therefore, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P9/10A61P25/28C07D311/30C07H1/08A61K127/00
Inventor 王立升刘力恒冯丹丹李鑫王元春
Owner GUANGXI UNIV
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