Hollow nanostructured hydroxyapatite and method for producing the same

A technology of hydroxyapatite and hollow nanometers, which is applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as limited applications, and achieve low raw material costs, simple experimental equipment, and good dispersion

Inactive Publication Date: 2009-05-13
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the diameter of the hydroxyapatite hollow spheres they prepared is as high as 5 microns, which limits its application in biomedicine and its industry

Method used

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  • Hollow nanostructured hydroxyapatite and method for producing the same
  • Hollow nanostructured hydroxyapatite and method for producing the same
  • Hollow nanostructured hydroxyapatite and method for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Preparation of elliptical hydroxyapatite hollow nanostructures with a length of 600-1000nm:

[0051] Add 0.005mol calcium nitrate, 0.003mol diammonium hydrogen phosphate, 0.005mol citric acid, 0.0013mol edetate disodium, 0.001mol sodium fluoride, 80mL deionized water to a 250mL three-necked flask, and place the three-necked flask at In a 40°C water bath, mechanically stir for 10 minutes. The resulting solution was a clear transparent liquid. The pH of the solution was then adjusted to 5.2 with 2M NaOH solution. After stirring for 5 min, the above solution was transferred into a 100 mL tetrafluoroethylene-lined hydrothermal kettle, and reacted at 150 °C for 4 h. After the product is centrifuged (4000hr / min, 10min), it is washed three times with deionized water and twice with absolute ethanol, and finally the product is placed in a vacuum drying oven and dried at 60°C for 8 hours. The resulting product was subjected to characterization tests.

[0052] figure 1 For th...

Embodiment 2

[0055] Preparation of elliptical hydroxyapatite hollow nanostructures with a length of 600-800nm:

[0056] Add 0.005mol calcium nitrate, 0.003mol ammonium dihydrogen phosphate, 0.005mol citric acid, 0.0025mol edetate disodium, 0.001mol sodium fluoride, 80mL deionized water to a 250mL three-necked flask, and place the three-necked flask at In a 40°C water bath, mechanically stir for 10 minutes. The resulting solution was a clear transparent liquid. The pH of the solution was then adjusted to 4.5 with 2M NaOH solution. After stirring for 5 min, the above solution was transferred into a 100 mL tetrafluoroethylene-lined hydrothermal kettle, and reacted at 130 °C for 2 h. After the product is centrifuged (4000hr / min, 10min), it is washed three times with deionized water and twice with absolute ethanol, and finally the product is placed in a vacuum drying oven and dried at 60°C for 8 hours. The resulting product was subjected to characterization tests.

[0057] image 3 For the...

Embodiment 3

[0060] Preparation of spindle-shaped hollow nanostructures of hydroxyapatite with a length of 1000-1200nm:

[0061] Add 0.005mol calcium nitrate, 0.003mol diammonium hydrogen phosphate, 0.005mol citric acid, 0.004mol edetate disodium, 0.001mol sodium fluoride, 80mL deionized water to a 250mL three-necked flask, and place the three-necked flask at In a 40°C water bath, mechanically stir for 10 minutes. The resulting solution was a clear transparent liquid. The pH of the solution was then adjusted to 3.6 with 2M NaOH solution. After stirring for 5 min, the above solution was transferred into a 100 mL tetrafluoroethylene-lined hydrothermal kettle, and reacted at 120 °C for 4 h. After the product is centrifuged (4000hr / min, 10min), it is washed three times with deionized water and twice with absolute ethanol, and finally the product is placed in a vacuum drying oven and dried at 60°C for 8 hours. The resulting product was subjected to characterization tests.

[0062] Figure ...

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Abstract

The invention relates to the technical field of nanometer materials and the preparation thereof, in particular to a hydroxyapatite with a hollow nanometer structure and a preparation method thereof. The outer appearance of the hydroxyapatite with the hollow nanometer structure is elliptic, spindle-shaped or hexagonal prism-shaped; and the nanometer structure is a hollow structure. The preparation method comprises the following steps: dissolving a certain quantity of calcium sources, phosphor sources, fluoride and chelating agents into deionized water; then adjusting the pH value of the solution; transferring the solution into a hydrothermal kettle and carrying out hydro-thermal reaction for a period time; and centrifuging, washing and drying after the reaction. Any templates and surface active agent are not used in the invention; the hollow nanometer structure of the hydroxyapatite is synthesized for one step; and the invention has the advantages of low cost, mild reaction conditions and simple devices required. The hollow nanometer structure of the hydroxyapatite prepared in the invention has uniform dimension, good dispersivity and large volume of a hollow part, and can be used as medicine and catalyst carriers.

Description

technical field [0001] The invention relates to the technical field of nanomaterials and their preparation, in particular to hollow nanostructured hydroxyapatite with three different shapes of oval, spindle and hexagonal columns and a preparation method thereof. technical background [0002] In recent years, nanostructures with special morphology have attracted extensive attention. As a special structure and morphology, hollow nanostructure has become a frontier field of chemistry and material science research. Due to its low density and high specific surface area, and its hollow part can accommodate a large number of guest molecules, hollow nanostructure materials can produce some peculiar properties based on the microscopic "wrapping" effect, making hollow nanostructures in micro-scale reactors, There are important applications in many technical fields such as drug carriers, photonic crystals, catalysts and energy storage. Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
Inventor 谢吉民姜德立陈敏朱建军李娣
Owner JIANGSU UNIV
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