Method and apparatus for refining D-glucuronolactone

Abstract

The invention relates to a method for refining crude products of glucurolactone, and a device for realizing the method. The method comprises the steps that: the crude products of glucurolactone are put into a dissolution kettle; purified water with the temperature of 80 DEG C to 90 DEG C from a purified water preheating gage tank and medical active carbon are put into the dissolution kettle according to a certain proportion; with the temperature kept constant, the mixture in the kettle is fully stirred and dissolved and put into a filter-pressing tank; clean air is pressurized to cause the material liquid to flow from the filter-pressing tank into a crystallization kettle; medical ethanol with the weight of about 10 percent to 20 percent of the crude products of glucurolactone is added into the crystallization kettle from an ethanol gauge tank; crystallized material liquid is dewatered and washed in a centrifuge and decompressed and dried to obtain the finished products of glucurolactone. The content of noxious substances in the finished products of glucurolactone produced by the method, such as iron, copper, arsenic, heavy metals, sulphate, chloride and the like, is greatly reduced, thus ensuring that the products are qualified in bacterial examination and the color dots do not exceed the standard.

Description

Technical field: [0001] The invention relates to a method and a device for refining glucuronolactone. Background technique: [0002] The full name of glucuronolactone in Chinese is glucuronolactone, commonly known as liver Taile, and its molecular formula is C 6 h 8 o 6 , its chemical composition is: D(+)-furanoglucuronic acid γ-lactone, English name: [D(ten)—Glucofuranurono—6,3—lactone]. As a liver detoxifier and immune function regulator, glucuronolactone is a conventional liver-protecting medicine; glucuronolactone and its follow-up products are also the main additives of functional drinks and foods, weight-loss drugs, cosmetic crystals, etc. It has the effects of replenishing physical energy, improving hypoxia, nourishing skin, and delaying aging. [0003] The main method for the current industrial production of glucuronolactone is the nitric acid oxidation method starting from starch. The process is: add starch to nitric acid with a content of about 80% (V / V) to oxi...

AI Technical Summary

Problems solved by technology

The main disadvantage of the method of suction filtration with multiple filter paper suction filters is that the device occupies a large area, consumes a lot of manpower and filter paper, and is not suitable for large-scale industrial production; the main disadvantage of the method of adding filter paper and filter cloth to the plate and frame filter press It consumes a lot of filter paper, and the plate and frame filter press has a large volume and is difficult to keep warm. As a result, glucuronide is easily crystallized in the plate and frame filter press and is lost.

These two refining methods will cause harmful substances such as iron, copper, arsenic, heavy metals, sulfates and chlorides in water, activated carbon and alcohol to enter the finished product, so that the product quality cannot meet the drug and food additive standards of developed countries such as Europe and the United States. ; These two refined methods will not be able to effectively filter out bacteria clusters and activated carbon particles visible to the naked eye due to the diafiltration of filter paper and filter cloth, making the product unqualified for bacterial inspection and color points exceeding the standard

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