Production method of high-content beta-sitosterin

A production method and technology for sitosterol are applied in the production field of high-content β-sitosterol, can solve problems such as trivial details, difficulty in separation, no production method for β-sitosterol, etc., achieve full utilization of resources, improve purity and yield , the effect of large-scale industrial production value and social benefits

Inactive Publication Date: 2009-05-20
西安蓝天生物工程有限责任公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the mixed phytosterols on the market contain about 40% β-sitosterol. Due to the extremely similar molecular structure and physical and chemical properties, it is a compar

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example one:

[0020] 1. 3000kg of vegetable oil deodorized distillate. The raw material of the present invention contains about 4% β-sitosterol, in addition to 80% fatty acid, 5% natural VE, about 3% other sterols and a small amount of triglycerides, etc. Other ingredients, put in 5m 3 In the enamel reactor, put 1200kg of methanol (input at room temperature) to start stirring, add 210kg of concentrated sulfuric acid, and at a temperature of 80℃, the esterification reaction uses acid as a catalyst and lower alcohol as the reaction solvent to carry out the esterification reaction. In 4 hours, the fatty acid containing 80% is esterified into fatty acid methyl ester to facilitate separation from the raw material. The end of the reaction of the esterification process takes the acid value less than 2 as the indicator. Set aside to separate the methanol and sulfuric acid mixture.

[0021] 2. Add 450kg of methanol to the enamel reactor containing 3000kg of esterified oil, start st...

Example Embodiment

[0026] Embodiment two:

[0027] 1. Take 500kg of vegetable oil deodorized distillate (containing about 7% of β-sitosterol), 3 Add 150kg of ethanol to the reaction kettle, stir to dissolve, add 30kg of phosphoric acid, reflux and stir at 70°C for 3 hours, stand still to separate ethanol and phosphoric acid.

[0028] 2. Add 100 kg of ethanol to the kettle, start stirring, add 5 kg of KOH, and stir at 70°C under reflux for 1 hour.

[0029] 3. Add 70kg, 80°C water to wash the oily reaction material, wash 3 times, to PH=7.

[0030] 4. Put the water-washed oil into the short-path distillation unit, and feed 4 liters per minute at 150°C and 50 Pa, and 200kg of fatty acid methyl esters can be separated.

[0031] 5. About 300kg of the reconstituted portion enters the filter press to filter at 70°C to obtain about 290kg of filtrate. At 70°C, 12kg of regulator is added, and the regulator is 10% sulfuric acid and water in a weight ratio of 1:2.5. Gradually reduce the temperature and cool to 3...

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PUM

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Abstract

The invention relates to a method for producing high-content Beta-sitosterin, which comprises the steps that: deodorized distillate of vegetable oil containing 4 percent to 7 percent of Beta-sitosterin is taken as the raw material and goes through the processes of esterification, alcoholysis, short-range separation, cold setting, filtering, washing of filter cakes, vacuum drying and the like. The method has the advantages that: (1) the high-content Beta-sitosterin (with the content higher than 80 percent) can be prepared directly from the deodorized distillate of the vegetable oil, thereby avoiding the complex processes that mixed phytosterin is obtained from the deodorized distillate of the vegetable oil and then purified and separated to obtain Beta-sitosterin, and creating great industrial productive value and social benefits; (2) the method uses a special non-toxic organic solvent and appropriate process conditions, thus greatly improving the purity and yield of the Beta-sitosterin and resulting in no environmental pollution; and (3) other by-products and solvents can be recycled, thereby fully utilizing resources and reducing production cost.

Description

technical field [0001] The invention relates to a production method of high-content β-sitosterol. Background technique [0002] β-sitosterol (β-sitosterol) widely exists in the fruits and seeds of various plants, and also exists in various vegetables and fruits. It forms a mixture with brassicasterol, campesterol, and stigmasterol. β-sitosterol can inhibit the absorption of cholesterol by the human body, promote the biochemical synthesis of cholesterol, and reduce cholesterol, while other phytosterol components have no value in inhibiting the absorption of cholesterol. Therefore, the content of β-sitosterol as a drug raw material must be more than 80%. At present, the mixed phytosterols on the market contain about 40% β-sitosterol. Due to the extremely similar molecular structure and physical and chemical properties, it is a comparison to separate 80% monomeric β-sitosterol with a higher purity. Difficult and cumbersome work, there is no mature production method of more th...

Claims

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Application Information

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IPC IPC(8): C07J9/00
Inventor 于佑世
Owner 西安蓝天生物工程有限责任公司
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