Pharmaceutical composition containing lycopene and preparation method thereof

A technology for lycopene and solid pharmaceutical preparations is applied in the field of lycopene-containing pharmaceutical compositions and their preparation, and can solve the problems of low bioavailability, low solubility of lycopene, poor dissolution and the like

Inactive Publication Date: 2009-05-27
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report of preparing lycopene into a preparation with high solubility, fast dissolution and stability. CN200610037859.5 discloses a "β-cyclodextrin and hydroxypropyl-β-cyclodextrin mixed clathrate tomato Composition of lycopene and its preparation method", this method improves the solubility of lycopene to a certain extent by preparing lycopene into

Method used

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  • Pharmaceutical composition containing lycopene and preparation method thereof
  • Pharmaceutical composition containing lycopene and preparation method thereof
  • Pharmaceutical composition containing lycopene and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of Lycopene Solid Dispersion and Its Tablets

[0046] Take 5g of lycopene and 1885g of poloxamer, add 600ml of tetrahydrofuran to ultrasound to dissolve, evaporate most of the solvent on a rotary evaporator, water bath temperature of 40℃, put it in vacuum for 24h, grind the dried product to obtain a solid dispersion .

[0047] Mix 256 g of lactose with the solid dispersion first, then add 5.6 g of differential silica gel, 2.8 g of cross-linked polyvinylpyrrolidone, and 5.6 g of magnesium stearate, mix well, and press 1000 tablets.

[0048] The tablets dissolve 75% in water in 45 minutes (n=6).

Embodiment 2

[0050] Preparation of Lycopene Solid Dispersion and Its Tablets

[0051] Take 5g of lycopene and 18815g of poloxamer, add 600ml of tetrahydrofuran to ultrasonically dissolve, and evaporate most of the solvent on a rotary evaporator. The temperature of the water bath is 40℃, and it is dried in vacuum for 24h. The dried product is ground to obtain a solid dispersion. .

[0052] Mix 251.6g of lactose with the solid dispersion first, 2.8g of cross-linked polyvinylpyrrolidone and 5.6g of magnesium stearate, mix evenly, and press 1000 tablets.

[0053] The tablets dissolve 76% in water in 45 minutes (n=6).

Embodiment 3

[0055] Preparation of Lycopene Solid Dispersion and Its Tablets

[0056] Take 5g of lycopene and 18825g of poloxamer, add 600ml of tetrahydrofuran to ultrasonically dissolve, evaporate most of the solvent on a rotary evaporator, water bath temperature of 40℃, put it in vacuum for 24h, grind the dried product to obtain a solid dispersion .

[0057] Mix 241.6g of lactose with the solid dispersion, dry granulation and granulate, add 2.8g of cross-linked polyvinylpyrrolidone and 5.6g of magnesium stearate, mix well, and press 1000 tablets.

[0058] The tablet can dissolve 83% in water in 45 minutes (n=6).

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Abstract

The invention relates to the pharmaceutical preparation field, in particular to a pharmaceutical composition with lycopene. The pharmaceutical composition is characterized in that poloxamer 188 is added so as to greatly improve the water solubility of the lycopene; in particular, after the lycopene and the poloxamer 188 are prepared into solid dispersion or, together with cyclodextrin, are prepared into a cyclodextrin iclusion complex, bioavailability of the lycopene is remarkably improved.

Description

Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition containing lycopene and a preparation method thereof. Background technique [0002] Lycopene, molecular formula C 40 H 36 , With a molecular weight of 536.85, is a kind of carotenoid. Among all carotenoids, it has the strongest function of eliminating singlet oxygen and eliminating free radicals. Its ability to eliminate singlet oxygen is carotene 2 times, 100 times that of vitamin E; it can slow down the oxidation of low-density lipoprotein, reduce cholesterol in plasma, and prevent cardiovascular disease; it can effectively inhibit the growth of cancer cells, has anti-cancer and anti-cancer effects, especially for prostate cancer It has a very good therapeutic effect. In addition, it has the function of activating immune cells, which can enhance the body's immunity and anti-aging. Lycopene has such a wide range of effects and has such unparalle...

Claims

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Application Information

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IPC IPC(8): A61K31/01A61K47/34A61P39/06A61K47/10A61K47/40
Inventor 平其能吕文莉戎飞毛毛
Owner CHINA PHARM UNIV
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