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Chinese medicine rapid-release preparation for oral cavity and method for producing the same

A technology of quick-release preparations and manufacturing methods, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of low tablet strength, large amount of excipients, discomfort, etc., and achieve the effect of taking convenience and improving the dispersion rate

Inactive Publication Date: 2009-05-27
何煜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many defects in these preparations, such as: granular feeling after disintegration, complicated preparation method, excessive water absorption is difficult to store, low tablet strength, etc.
Because the rapid release of the tablet is inversely proportional to the strength of the tablet, the amount of excipients is large and the amount of the main drug is limited
These dosage forms rely entirely on a small amount of water in the mouth to produce immediate release. When the saliva in the mouth is insufficient, the tablet will adhere to the oral mucosa and cause discomfort.
These problems are difficult to break through in the existing preparation mode

Method used

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  • Chinese medicine rapid-release preparation for oral cavity and method for producing the same
  • Chinese medicine rapid-release preparation for oral cavity and method for producing the same
  • Chinese medicine rapid-release preparation for oral cavity and method for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Embodiment 1: the manufacture method of Shengmai preparation

[0119] (1) Material preparation: main ingredients (ginseng 100Kg, Ophiopogon japonicus 200Kg, Schisandra chinensis 100Kg), auxiliary materials (sugar 300Kg, hydrogenated vegetable oil 300Kg, lecithin 10kg)

[0120] (2) Slurry preparation: Semi-dry method, roller grinding method (see Figure 6 ). Specifically: crush 100Kg of ginseng, 200Kg of Ophiopogon japonicus, and 100Kg of schisandra to 200 mesh, add 300Kg of white sugar and 180Kg of hydrogenated vegetable oil (35-60°C), mix them, and pre-grind them in a two-roll mill (or three-roll mill) to 60- 150 microns, and then enter the five-roll mill (or three-roll mill) for grinding to 20-35 microns. Then put the material into a mixer (refiner) and stir (refine) for 5 hours, during which 90Kg of hydrogenated vegetable oil is gradually added according to the viscosity of the material, and 30Kg is reserved to add together with lecithin 1 hour before the end. Thi...

Embodiment 2

[0122] Embodiment 2: the manufacture method of Shengmai preparation

[0123] (1) Material preparation: main ingredients (ginseng 100Kg, Ophiopogon japonicus 200Kg, Schisandra chinensis 100Kg), auxiliary materials (sugar 300Kg, hydrogenated vegetable oil 300Kg, lecithin 10kg)

[0124] (2) Slurry preparation: wet method, fine grinding method (see Figure 7 ). Specifically: Grind 100Kg ginseng, 200Kg Ophiopogon japonicus, and 100Kg schisandra chinensis to 200 mesh, add 300Kg sugar powder and 270Kg hydrogenated vegetable oil (35-60°C) successively (or add after mixing) and grind them to 25 microns . Reserve 30Kg of hydrogenated vegetable oil and add it together with lecithin 1 hour before the end.

[0125] (3) Molding: after fine grinding, discharge the material, pour it into a pre-set mold, then cool and solidify, take it out of the package, 10g / piece.

Embodiment 3

[0126] Embodiment 3: the manufacture method of Shengmai preparation

[0127] (1) Material preparation: main ingredients (ginseng 100Kg, Ophiopogon japonicus 200Kg, Schisandra chinensis 100Kg), auxiliary materials (sugar 300Kg, hydrogenated vegetable oil 300Kg, lecithin 10kg)

[0128] (2) Slurry preparation: adopt wet method, ball milling method (see Figure 8 ). Specifically: Grind 100Kg ginseng, 200Kg Ophiopogon japonicus, and 100Kg schisandra chinensis to 200 mesh, add 300Kg white sugar (or powdered sugar) and 300Kg hydrogenated vegetable oil (35-60°C) successively (or add after mixing) in a ball mill and grind to 25 microns . Lecithin is added successively during the grinding process.

[0129] (3) Molding: Discharge after ball milling, pour into a pre-set mold, then cool and solidify, take out the package, 10g / piece.

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Abstract

The invention relates to a traditional Chinese medicine mouth immediate-release preparation and a preparation method thereof. Basic raw materials of the preparation include a main material and a subsidiary material. The main material is traditional Chinese medicine which includes traditional Chinese medicine materials, traditional Chinese medicine decoction pieces or traditional Chinese medicine extracts; the subsidiary material is oil dispersant and can be added with water-soluble dispersant, flavoring and surface active agent when necessary; and the weight percentage of the main material is 0.1 percent to 80 percent, and the weight percentage of the subsidiary material is 20 percent to 99.9 percent. The detail operating steps are as below: (1) preparation of the materials; (2) preparation of a sizing agent: thinning and liquefying are included, final fineness of the thinning is less than 200 microns in the case of 95 percent of the preparation by weight, the liquefying is that solid grains are dispersed in the oil dispersant by means of mixing, and the weight percentage of the addition of the oil dispersant meets the condition that oil content in a finished product is not less than 15 percent; and (3) formation: the finished preparation is obtained by adopting a cooling forming method or a powder forming method. The traditional Chinese medicine mouth immediate-release preparation improves the dispersing speed of the traditional Chinese medicine components in the mouth in the precondition of good mouth taste, no water drinking is needed, and the taking of the traditional Chinese medicine mouth immediate-release preparation is convenient.

Description

(1) Technical field: [0001] The invention provides a traditional Chinese medicine oral quick-release preparation and a manufacturing method thereof, belonging to the technical field of traditional Chinese medicine preparations. (two) background technology: [0002] In the manufacturing method of traditional Chinese medicine, pills and powders are common dosage forms of oral preparations of Chinese patent medicines, and are typical applications of standardization and commercialization of Chinese medicines. However, honeyed pills and watered pills have poor mouthfeel and slow dispersion; although powders have a quick onset of action, they are prone to moisture absorption and caking, and also have the disadvantages of poor mouthfeel. In the past two decades, traditional Chinese medicine formulations have been reformed by adopting western medicine preparations, such as capsules, tablets, oral liquids, concentrated pills, granules, granules, dripping pills and other oral preparat...

Claims

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Application Information

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IPC IPC(8): A61K36/00A61K47/44
CPCA61K36/8968A61K36/258A61K36/57A61K9/0056
Inventor 何煜
Owner 何煜
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