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Chinese medicine granule containing prepared rehmannia root extract and preparation method thereof

A technology of traditional Chinese medicine granules and extracts, which is applied in the field of traditional Chinese medicine granules containing Rehmannia glutinosa extract and its preparation, can solve the problems of lack of immediate release characteristics, low drug loading of granules, and unsightly appearance, and achieve good physical properties, The effect of small specific surface area and short dissolution time

Inactive Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Extraction of extract: Rehmannia glutinosa 80g, Cornus officinalis 40g, Moutan bark 30g, Chinese yam 50g, Poria cocos 40g and Alisma 40g for later use; the above six flavors, Moutan bark extract paeonol; medicine dregs and dogwood 15g, Rehmannia glutinosa, Poria cocos, Alisma alisma Add water and decoct 3 times, each time for 3 hours, combine the decoction, filter, and concentrate the filtrate to a thick paste with a relative density of 1.10-1.40; crush the yam and remaining dogwood into fine powder, sieve, and mix well; put the above thick paste , fine powder, and paeonol are mixed to obtain the Chinese medicine extract.

[0045] Preparation of masterbatch: Take the mixture of dextrin and starch (1:1) and pass it through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and take starch and extract (after being folded and dried to account for the masterbatch) 15% of the weight) is added with water to form a slurry...

Embodiment 2

[0048] Preparation of extracts: Rehmannia glutinosa 320g, Cornus officinalis 160g, Cortex Moutan 100g, Chinese yam 150g, Poria cocos 80g and Alisma 100g for later use; the above six flavors, Rehmannia glutinosa, Poria cocos and Alisma japonica are decocted twice, the decoction is filtered, and the filtrate is concentrated The relative density at 80°C is 1.10-1.45, and it is used for later use; Cornus officinalis, Chinese yam, and Moutan cortex are crushed into fine powder, and mixed with the concentrated solution to obtain the Chinese medicine extract;

[0049] Preparation of masterbatch: take a mixture of dextrin and polyethylene glycol at a ratio of 1:1 and pass through a 200-mesh sieve, 50% of which will be used as the base material and put into the side spray pot of the fluidized bed, and starch will be taken and dried to account for the weight of the masterbatch 25% of the extract is prepared by adding water to make a slurry and spray it in, and sieve out small particles w...

Embodiment 3

[0052] Preparation of extracts: Rehmannia glutinosa 200g, Cornus officinalis 100g, Cortex Moutan 100g, Chinese yam 90g, Poria cocos 70g and Alisma 70g for later use; the above six flavors, rehmannia glutinosa, Poria cocos, and Alisma japonica are decocted twice, the decoction is filtered, and the filtrate is concentrated The relative density at 80°C is 1.10-1.45, and it is used for later use; Cornus officinalis, Chinese yam, and Moutan cortex are crushed into fine powder, and mixed with the concentrated solution to obtain the Chinese medicine extract;

[0053] Preparation of masterbatch: Take the mixture of dextrin and starch (1:1) and pass it through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and take starch and extract (after being folded and dried to account for the masterbatch) 15% of the weight) is added with water to form a slurry and sprayed in, and sieve out small particles (180-250 μ) as the mother nucleus...

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Abstract

The invention provides a traditional Chinese medicine granular preparation and a preparation method thereof. In the invention, traditional Chinese medicine spheroidized particles are prepared by traditional Chinese medicine extractive and carriers acceptable in pharmacy. The outline of the traditional Chinese medicine spheroidized particles takes sphere shape or round type shape. The density of the preparation is 0.6-1.3 g / ml. The spheroidized particles of the invention have low single dose, are convenient in use, can be served as intermediate products of capsules, and also can be used for developing a traditional Chinese medicine controlled release preparation.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing rehmannia glutinosa extract and a preparation method thereof. Background technique [0002] Liuwei Dihuang Pills evolved from Qian Yi, a famous pediatrician in the Northern Song Dynasty, according to the representative prescription "Shenqi Pills" for nourishing kidney yang in "Synopsis of the Golden Chamber" written by medical sage Zhang Zhongjing. It is a basic prescription for nourishing kidney yin and has been widely used. Because of various diseases caused by kidney yin deficiency, it was praised by later generations as the founder of the "Yin Nourishing Method". With the promotion of clinical application, its dosage form has also evolved from a single dosage form of pills to water pills, dripping pills, concentrated pills, granules, etc. [0003] The traditional preparation method...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K36/8945A61K9/16A61P1/14A61P13/12
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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