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Medical device with cell-regeneration reinforcing function and manufacture method thereof

A technology for medical equipment and sutures, applied in medical science, surgery, surgical instruments, etc., can solve the problems of complex design and difficult commercialization of technology

Inactive Publication Date: 2009-06-10
韩完锡
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, existing technologies are considered insufficient for these functions and face difficulties in commercializing the technology due to its complexity in design

Method used

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  • Medical device with cell-regeneration reinforcing function and manufacture method thereof
  • Medical device with cell-regeneration reinforcing function and manufacture method thereof
  • Medical device with cell-regeneration reinforcing function and manufacture method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1 separates and purifies dulcitol from dulcis

[0060] Separate the leaves, stems and roots of euonymus, wash with water, chop finely, and dry in a cool place until there is no change in weight. Each part of 1 kg of dried euonymus was added to 1 liter of ethanol, extracted at 60° C. for 8 hours, and filtered with gauze. The ethanol was then completely evaporated using a rotary vacuum evaporator (Heidolph WB2000, Germany), thereby obtaining fractions of extracts.

[0061] 200 ml of distilled water was added to the extracts of each fraction and fractionated using diethyl ether. Then, the fractionated aqueous layer was concentrated and fractionated using ethyl acetate to obtain an organic solvent layer. The organic solvent layer was treated by freeze-drying, thereby obtaining the extracted powder of each fraction.

[0062] The extracted powder of each part was dissolved in 100 ml of distilled water, and then separated by silica gel column chromatography, usin...

Embodiment 2-7

[0065] Examples 2-7: Preparation of Sutures with Different Collagen Contents

[0066] Bovine-derived collagen was dissolved in pure water at 50° C. to prepare collagen coating solutions having 30, 40, 50, 60, 70 and 80% by weight of collagen, respectively. The spools wound with polydioxanone monofilaments were soaked in the collagen coating solution for 30 min, stirred and dried at 22 °C to obtain collagen-coated polydioxanone sutures.

[0067] The dulcitol of Example 1 was dissolved in pure water at 50° C. to prepare a dulcitol coating solution having 10% by weight of dulcitol. The spools of wound polydioxanone monofilaments coated with collagen were soaked in dulcitol coating solution for 30 min, stirred and dried at 22 °C to obtain collagen and dulcitol-coated polydioxanone monofilaments. Oxanone sutures.

Embodiment 8-12

[0068] Examples 8-12: Preparation of sutures with different dulcitol contents

[0069] A collagen coating solution having 50% by weight of collagen was prepared by dissolving bovine-derived collagen in pure water at 50°C. The bobbins wound with polydioxanone monofilaments were soaked in the collagen coating solution for 30 minutes, stirred and dried at 22° C. to obtain collagen-coated polydioxanone sutures.

[0070] The dulcitol of Example 1 was dissolved in pure water at 50° C. to prepare dulcitol coating solutions having 3, 5, 10, 15 and 20% by weight of dulcitol, respectively. A spool of wound polydioxanone suture coated with collagen was soaked in dulcitol coating solution for 30 min, stirred and dried at 22 °C to obtain collagen and dulcitol-coated polydioxan Alkanone sutures.

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Abstract

The invention relates to a medical facility having cell regeneration function and a method thereof, in particularly, polydioxin anonesu azululanone single filament is coated with collagen and melampyrit for manufacturing the medical facility. The medical facility can promote healing of cutting wound that promotes cell regeneration and displays hemostasia function, also can improve skin elasticity. The medical facility is made of sewing material that has biocompatibility, suitable tensile-strength, perfect sliding characteristic, improved keeping quality and perfect skin regeneration ability, thereby, quality is not changed even if keeping for a long time, and the sewing area recovers rapidly after being sewed on skin. One end of a needle in the facility is installed on a handle, another end is equipped with a sharp top through human body, and a center space pass through by the sewing material. The center space includes the needle inside and the handle center part.

Description

technical field [0001] The invention relates to a medical device with cell regeneration function and a manufacturing method thereof. More specifically, the medical device was fabricated by coating polydioxanone monofilaments with collagen and dulcitol. The medical device enhances cell regeneration as it promotes healing at the incision site, and the medical device has a hemostatic effect and improves skin elasticity. The medical device is composed of a suture and a medical device, the suture has biocompatibility, suitable tensile strength, good sliding properties and improved preservation and good skin regeneration ability, thereby, treated with the suture After the skin, the quality of the suture does not change even if it is kept for a long time, and the suture area recovers quickly. This medical device has a needle with a handle on one end and a sharp tip that can penetrate the human body at the other end, and this medical device is useful In the interior space of the sut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61B17/06
Inventor 韩完锡
Owner 韩完锡