Single-optical fiber multiphoton fluorescence scanning endoscope

Abstract

The invention relates to a single-fiber multi-photon fluorescent scanning endoscope, applied in early screening and diagnosis of various mucosa cancers of human body. A single mode fiber is carried inside an endoscope system to enter a human body and guide extracorporeal ultrashort pulse laser into intracorporeal target cell, and an acousto-optic deflector is adopted to carry out laser deflexion in two orthogonal directions; moreover, the endoscope adopts a piezocrystal to perform fine adjustment on the focus of the lens group so as to adjust fluorescence excitation depth, and adopts a multi-photon fluorescent imaging mechanism to eliminate confocal pinholes; therefore, the endoscope reduces the process difficulty of making acousto-optic deflexion scanning front end and also overcomes mechanical inertia of devices adopting micromechanics to realize deflexion scanning so as to ensure convenient integrated molding and miniaturization of an entire scanning imaging tail end. The system provided by the invention can carry out cell morphologic analysis on suspect cancer cells at low cost during routine endoscope examination.

Description

technical field [0001] The invention relates to an optical system, in particular to an optical system applied in the technical field of early screening and diagnosis of various mucosal cancers of the human body. Background technique [0002] The current gold standard for cancer diagnosis is the pathological section of diseased tissue cells. Diagnostic doctors use a microscope to zoom in on the pathological section to obtain the morphological characteristics of the tissue cells, so as to determine whether the pathological section contains cancerous cells. [0003] Although the method of pathological section is of great significance for the diagnosis of advanced cancer, but this method is invasive, the diagnosis cycle is long, and it may cause the artificial spread of cancer cells in the process of obtaining tissue cells; on the other hand, early detection of cancer can Greatly improve the cure rate of cancer and prolong the survival period of cancer patients. [0004] For so...

AI Technical Summary

Problems solved by technology

The multi-photon scanning mechanisms and methods recorded in the current literature and patents all use micromechanical mechanisms, or piezoelectric crystals to drive the end of the optical fiber, and scan the target area along a certain horizontal and vertical axes. Since the mechanical vibration is nonlinear vibration, and The structure is complex, the production cost is high, and there is mechanical inertia, which is not conducive to the improvement of scanning speed, and the human organs are always wriggling, resulting in motion blur of the image

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