Huperzine A mono-layer osmotic pump controlled release tablets
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A single-layer osmotic pump and huperzine A technology, applied in the field of medicines containing huperzine A, can solve problems such as pain, fast drug release, complicated preparation process, etc., achieve stable drug release rate, and reduce the number of medications , The effect of constant blood drug concentration
Inactive Publication Date: 2009-07-22
普尔药物科技开发(深圳)有限公司
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Problems solved by technology
[0005] Existing huperzine A oral and injection preparations have the following defects: (1) in order to avoid gastrointestinal adverse reactions, regular injections are required, causing
Method used
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Embodiment 1
[0108] prescription:
[0109] Drug-containing layer of tablet core Huperzine A 0.2g
[0110] Yellow iron oxide 0.5g
[0111] Sodium chloride 10.0g
[0112] Mannitol 127.5g
[0113] Povidone K30 10.0g
[0114] Magnesium Stearate Appropriate amount
[0115] 150.0mg per tablet
[0116] A total of 1000 pieces
[0117] Coating liquid cellulose acetate 25.0g
[0118] Polyethylene glycol 4.125g
[0119] Acetone 850mL
[0120] Ethanol 150mL
[0121] Preparation Process:
[0122] Including the following steps:
[0123] a. Mix huperzine A and other pharmaceutical excipients according to the method of equal increase to make a mixture;
[0124] b. Mix the mixture with 10% povidone K30 ethanol solution to make a soft material, the amount of the added ethanol solution is to make the s...
Embodiment 2
[0130] prescription:
[0131] Drug-containing layer of tablet core Huperzine A 0.015g
[0132] Yellow iron oxide 0.5g
[0133] Sodium chloride 60g
[0134] Lactose 75.96g
[0135] Povidone K30 12.0g
[0136] Magnesium stearate 1.525g
[0137] 150.0mg per tablet
[0138] A total of 1000 pieces
[0139] Coating liquid cellulose acetate 25.0g
[0140] Polyethylene glycol 1.25g
[0141] Acetone 850mL
[0142] Ethanol 150mL
[0143] Preparation process: with embodiment 1.
[0144] Film weight gain: 19mg per tablet.
Embodiment 3
[0146] prescription:
[0147] Drug-containing layer of tablet core Huperzine A 0.75g
[0148] Yellow iron oxide 0.5g
[0149] Sodium chloride 60.5g
[0150] Starch 60g
[0151] Tartaric acid 12g
[0152] Povidone K30 15.0g
[0153] Magnesium Stearate 1.25g
[0154] 150.0mg per tablet
[0155] A total of 1000 pieces
[0156] Coating liquid cellulose acetate 25.0g
[0157] Polyethylene glycol 6.25g
[0158] Acetone 850mL
[0159] Ethanol 150mL
[0160] Preparation process: with embodiment 1.
[0161] Film weight gain: 17mg per tablet.
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Abstract
The invention discloses a huperzine A single-layer osmotic pump controlled-release tablet. The controlled-release tablet comprises a tablet core containing huperzine A and pharmaceutic adjuvants in effective dosage, and a semipermeable coating membrane coating the tablet core, wherein the coating membrane is provided with a drug release hole. The controlled-release tablet is characterized in that: the tablet core contains the following components in percentage by weight: 0.01 to 1.0 percent of huperzine A, 1.0 to 10 percent of retarder and 1.0 to 40 percent of permeation enhancer; and the weight ratio of polyethylene glycol 6,000 contained in the coating liquid to cellulose acetate is (0.05-0.25):1, and the weight gain of the coating membrane against the weight of the tablet core is between 5 and 25 percent. The controlled-release tablet has the advantages that the drug release rate is stable, the blood consentration of patients is relatively constant after the patients take the controlled-release tablet, and the drug taking frequency of the patients is reduced, so that the controlled-release tablet is a novel drug formulation which is safer, more effective, stable, controllable and convenient for application in clinically treating senile dementia.
Description
technical field [0001] The invention relates to a medicine containing huperzine A component, in particular to a huperzine A monolayer osmotic pump controlled release preparation. Background technique [0002] Huperzine A (Huperzine A) is a lycopodium alkaloid extracted from Huperziaserrata (Thunb) Trev, a plant of the Huperzaceae family. It has remarkable effects in enhancing learning and memory, improving spatial memory impairment, etc., and has become one of the research hotspots of global concern. In recent years, the research on the pharmacological effects of huperzine A has continued to deepen and expand, showing multi-directional and multi-angle anti-aging and nootropic effects. The main manifestations are: inhibiting the activity of acetylcholinease, regulating the oxygen free radical system, protecting the brain from hypoxic-ischemic damage, and improving the ability of learning and memory. Both animal experiments and clinical studies have shown that huperzine A, a...
Claims
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Application Information
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