DPP-IV inhibitor with sulfonamide formamide piperazine structure

A technology based on alkyl and cyano groups, which can be used in medical preparations containing active ingredients, organic chemistry, organic active ingredients, etc., and can solve problems such as limited drug varieties
CN101486689AActive Publication Date: 2009-07-22XUANZHU BIOPHARMACEUTICAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XUANZHU BIOPHARMACEUTICAL CO LTD
Publication Date
2009-07-22

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Abstract

The invention pertains to the field of medical technology, particularly relating to a DPP-IV inhibitor with a sulfamido formamide piperazine structure shown in the general formula (I), pharmaceutically acceptable salt or an isomer thereof, wherein, R, R, R and Ar are defined as the instruction book; the invention also relates to a preparation method of the compounds, a pharmaceutical composition containing the compounds and applications of the compounds in the preparation of medicaments for treatment and / or prevention of diabetes, noninsulin-dependent diabetes, hyperglycemia, insulin resistance.
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Description

1. Technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a DPP-IV inhibitor having a sulfonamidoformamide piperazine structure, a pharmaceutically acceptable salt or an isomer thereof, a preparation method of these compounds, and a pharmaceutical combination containing these compounds compounds, and the application of these compounds in the preparation of drugs for treating and / or preventing diabetes, non-insulin-dependent diabetes, hyperglycemia, and insulin resistance. 2. Background technology

[0002] Diabetes is a systemic chronic metabolic disease caused by uncontrolled blood sugar levels higher than normal. Basically divided into four categories, including: type I (insulin-dependent), type II (non-insulin-dependent), other types and gestational diabetes. Type 1 and type 2 diabetes belong to primary diabetes, the two most common forms, caused by the interaction of genetic and environmental factors. The etiology o...

Claims

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