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Dexmedetomidine and use of pharmaceutical salt thereof

A technology of dexmedetomidine and medicinal salt, which is applied in the field of pharmaceutical preparations, can solve problems such as hypertriglyceridemia, and achieve the effects of reducing incidence, expanding medical use, and reducing usage

Inactive Publication Date: 2009-08-05
四川国瑞药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The solvent of propofol is emulsified fat, which provides calories 1.1 calories / ml, and long-term or large-scale application may also cause hypertriglyceridemia
[0005] Opioid analgesics, represented by morphine, also have dual effects of analgesia and sedation, but usually clinical use is mainly based on analgesic effect, and therapeutic doses of morphine can sometimes cause dizziness, nausea, vomiting, constipation, dysuria, and biliary colic , respiratory depression, drowsiness and other side effects

Method used

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  • Dexmedetomidine and use of pharmaceutical salt thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] This example studies the preoperative and intraoperative sedative effects of dexmedetomidine.

[0024] Select 50 young patients (ASA I~II) and randomly divide them into two groups, Dex sedation group (group D) and control group (group C), with 25 cases in each group. All patients do not use preoperative drugs.

[0025] After entering the operating room, the median cubital vein was opened. After resting on the supine position for 10 minutes before epidural puncture catheterization, group D used a Graseby 3500 pump to intravenously infuse dexmedetomidine hydrochloride with a loading dose of 0.4 μg / kg (after 5 minutes of pumping), and then with 0.4 μg / (kg h) Intravenous infusion was maintained for 30 minutes; group C was infused with normal saline in the same way.

[0026] Monitor all patients' EEG bispectral index (BIS), auditory evoked potential index (A-line ARXIndex, AAI), MAP (mean arterial pressure), HR (heart rate), SpO 2 (pulse oximetry), PETCO 2 (end-tidal part...

Embodiment 2

[0035] This example studies the preoperative and intraoperative sedative effects of dexmedetomidine (Dex) and its influence on the depth of anesthesia in patients under general anesthesia.

[0036] There were 60 patients scheduled for elective surgery (ASA I-II class). They were divided into sedation group and anesthesia group according to different medication periods, 40 cases in each group.

[0037] The 40 cases in the sedation group were further divided into the Dex group (D 1 group) and control group (C 1 group), 20 cases in each group. All patients did not use premedication. D. 1 Dex was added intravenously before operation in the group; C 1 The group did not use Dex before operation. After entering the room and lying down for 10 minutes, D 1Dex was infused intravenously with a Graseby 3500 pump, with a loading dose of 0.4ug / kg (after 5min pumping), and then 0.4ug·kg-1·h -1 Maintain intravenous infusion for 30 minutes; C 1 The control group was infused with norma...

Embodiment 3

[0043] This example studies the intraoperative induction effect of dexmedetomidine, propofol and etomidate and the influence on the circulatory system.

[0044] Forty-five cases of elective surgery patients of grade I~II were randomly divided into three groups, namely, dexmedetomidine (group D), isopofol (P) group and etomidate (E) group. There were 15 cases in each group, and the induction effects of the three drugs and the effects on the circulatory system were mainly observed.

[0045] There was no significant difference in gender, age, weight and height among the above groups (P>0.05). The types of surgery include lobectomy, brain surgery, radical mastectomy, radical gastrectomy, cholecystectomy, etc. Anesthesia method: phenobarbital sodium 0.1mg, atropine 0.5mg, intramuscular injection 1 hour before operation. During the induction, after 5 minutes of oxygen inhalation by face mask, intravenous injection of dexmedetomidine 0.8ug / kg was completed within 5 minutes, and pro...

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Abstract

The invention discloses application of dexmedetomidine and medicinal salts of the same. The dexmedetomidine or the medicinal salts of the same are used for preparing a medicine used for sedateness by preoperative patients, intraoperative patients, postoperative patients and patients requiring trachea cannulas and endoscope cannulas. The medicine contains clinically effective quantity of the dexmedetomidine or the medicinal salts of the same, and the dexmedetomidine or the medicinal salts of the same is an only active agent and made into the medicine for intravenous administration; and the medicine is fed under the condition of administration until the blood plasma concentration is between 0.1 and 2 ng / ml. The invention increases a method for using the dexmedetomidine or the medicinal salts of the same, and not only widens the medicine application of the dexmedetomidine but also can make more non-ICU patients acquire good mitigative and analgesic effects and reduce the dosage of other similar medicines and the incidence rate of untoward reactions.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to the preparation of dexmedetomidine and its pharmaceutically acceptable salts for sedation and sedation of patients before, during, and after surgery and patients who need tracheal intubation or endoscopic intubation. Analgesic drug use. Background technique [0002] In clinical practice, patients usually feel anxiety, fear and uneasiness before and after various operations, and patients need to use analgesics to relieve pain after operations. The commonly used drugs are benzodiazepines (to reduce anxiety), propofol (to reduce anxiety), opioids (to reduce pain) and so on. [0003] Benzodiazepines include midazolam, lorazepam, and diazepam, etc. Midazolam can cause respiratory depression and blood pressure drop when injected too quickly or in large doses, especially in patients with hypovolaemia. , Continuous slow intravenous infusion can effectively reduce it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164A61P25/20A61P25/04
Inventor 朱义陈颖
Owner 四川国瑞药业有限责任公司
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