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Preparation method of inorganic calcium phosphate salt/biodegradable polymer fiber film composite material

A biodegradable, calcium phosphate technology, applied in medical science, prosthesis, etc., can solve the problem that the biological activity and remineralization of calcium phosphate cannot be fully exerted, affect the morphology of composite fibers, the mechanical properties of orientation degree, and cannot be controlled. The distribution of mechanical properties in space of composite materials

Inactive Publication Date: 2009-08-19
SOUTHWEST JIAOTONG UNIV
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Problems solved by technology

However, this preparation method has disadvantages: 1. Due to the addition of calcium phosphate salt, the electrospinning performance of the polymer solution system is changed, thereby affecting the morphology, orientation, and mechanical properties of the composite fiber; 2. Calcium phosphate salt The distribution is not regular and controllable, the mechanical properties are unstable, and the biological activity and remineralization of calcium phosphate salt cannot be fully utilized; 3. The tensile properties of the prepared composite fiber membrane are uncontrollable in the direction, and the composite fiber membrane cannot be controlled The spatial mechanical properties distribution of the material; while the composite system of collagen fibers and hydroxyapatite nanoparticles in the body is staggered in three-dimensional space, and the bone tissue material has anisotropic characteristics that meet the requirements of the human body in terms of mechanical properties, such as: the bone material requirements of the knee joint It has isotropic mechanical (tensile) properties, and the femur material is required to have better mechanical properties in the longitudinal direction; therefore, the composite fiber membrane mechanically assisted bone repair tissue engineering support or parts prepared by the existing method, It is difficult to have mechanical properties and isotropic properties consistent with damaged bone tissue in three-dimensional space

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  • Preparation method of inorganic calcium phosphate salt/biodegradable polymer fiber film composite material

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specific Embodiment approach

[0024] A kind of embodiment of the present invention is, a kind of preparation method of inorganic calcium phosphate salt / biodegradable polymer fiber film composite material, and its method is:

[0025] Prepare polylactic acid fiber film with a thickness of 100 μm by electrospinning polylactic acid, and collect it with a high-speed roller with a line speed of 16.7m / s to obtain a polylactic acid oriented fiber film with a fiber orientation degree of more than 80%; soak the oriented fiber film In 2mg / mL gelatin / phosphate buffer, react at 2-4°C for 24 hours, after washing, the gelatin grafting amount is 0.02nmol / cm 2 The polylactic acid oriented fiber membrane; then mineralized in vitro, that is, soaking it in human simulated body fluid with a concentration of 1.5 times, soaking it for 7 days at 37°C, taking it out and cleaning it, and obtaining nano inorganic calcium phosphate / biodegradable polylactic acid Composite oriented fiber film, wherein the low crystalline calcium phosph...

Embodiment 2

[0028] Prepare polylactic acid fiber membranes with a thickness of 75 μm by electrospinning polylactic acid, and use a high-speed roller with a line speed of 16.7m / s to collect polylactic acid oriented fiber membranes with a fiber orientation of more than 80%; soak the oriented fiber membranes In 2mg / mL gelatin / phosphate buffer, react at 2-4°C for 24 hours, after washing, the gelatin grafting amount is 0.02nmol / cm 2 Polylactic acid oriented fiber membrane; then in vitro mineralization, that is, immersing it in 1.5 times the concentration of human simulated body fluid, immersing it at 37 ° C for 7 days, taking it out and cleaning it, and obtaining nano inorganic calcium phosphate / biodegradable polymer Lactic acid composite oriented fiber film, wherein the low crystalline calcium phosphate content is 15.1% (the preparation method of the polylactic acid composite oriented fiber film of this example is the same as that of Example 1).

[0029] 8 layers of composite fiber membranes ...

Embodiment 3

[0031] This embodiment is basically the same as Embodiment 2, the difference is only:

[0032] Polylactic acid fiber membranes with a thickness of 150 μm were prepared by electrospinning.

[0033] Four layers of composite fiber membranes with a thickness of 150 μm were superimposed and arranged according to the fiber orientation angle between adjacent layers at 45°, and then subjected to hot-pressing treatment to obtain a composite material.

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Abstract

The invention discloses a method for preparing composite material from inorganic calcium phosphate salt / biodegradable polymer fiber membrane. The method comprises the steps of superposing more than two inorganic calcium phosphate salt / biodegradable polymer fiber membranes to form a multilayer composite fiber membrane and hot press molding on the multilayer composite fiber membrane, wherein the orientation degree of fibers in the inorganic calcium phosphate salt / biodegradable polymer fiber membranes is more than 80 percent, and the included angle of the fiber orientation of adjacent layers of the multilayer composite fiber membrane is between 0 and 90 degrees. The method has the advantages of high adaptability, simple process, low cost and good repeatability. The prepared composite material has biological activity and remineralization performance, high mechanical properties and direction controllability.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable composite material. Background technique [0002] Biodegradable composite materials are widely used in biomedical engineering fields such as medical implants, tissue repair and regeneration. Since it is difficult for a single material to meet the requirements of clinical mechanical and biological properties, the combination of different materials to obtain composite materials with special properties has become a research hotspot in current biomedical materials. Inorganic calcium phosphate / biodegradable polymer composites have good biodegradability and biocompatibility, and have been widely studied and applied in the field of bone tissue engineering. The use of new composite materials requires uniform distribution of inorganic particles in the composite system, good bonding force between inorganic particles and polymer substrates, high mechanical properties of composite materials, and the...

Claims

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Application Information

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IPC IPC(8): A61L27/46
Inventor 李孝红陈建刚崔文国冯波周绍兵
Owner SOUTHWEST JIAOTONG UNIV
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