Preparation method of inorganic calcium phosphate salt/biodegradable polymer fiber film composite material

A biodegradable, calcium phosphate technology, applied in medical science, prosthesis, etc., can solve the problem that the biological activity and remineralization of calcium phosphate cannot be fully exerted, affect the morphology of composite fibers, the mechanical properties of orientation degree, and cannot be controlled. The distribution of mechanical properties in space of composite materials

Inactive Publication Date: 2009-08-19
SOUTHWEST JIAOTONG UNIV
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Problems solved by technology

However, this preparation method has disadvantages: 1. Due to the addition of calcium phosphate salt, the electrospinning performance of the polymer solution system is changed, thereby affecting the morphology, orientation, and mechanical properties of the composite fiber; 2. Calcium phosphate salt The distribution is not regular and controllable, the mechanical properties are unstable, and the biological activity and remineralization of calcium phosphate salt cannot be fully utilized; 3. The tensile properties of the prepared composite fiber membrane are uncontrollable in the direction, and the composite fiber membrane cannot be controlled The spatial mechanical properties distribution of the material; while the composite sys

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  • Preparation method of inorganic calcium phosphate salt/biodegradable polymer fiber film composite material

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Example Embodiment

[0023] Example 1:

Example Embodiment

[0024] A specific embodiment of the present invention is, a preparation method of inorganic calcium phosphate / biodegradable polymer fiber membrane composite material, the method is:

[0025] Polylactic acid is prepared by electrospinning to prepare a polylactic acid fiber film with a thickness of 100 μm, and a high-speed roller with a linear speed of 16.7 m / s is used to collect a polylactic acid oriented fiber film with a fiber orientation degree of more than 80%; soak the oriented fiber film. In 2mg / mL gelatin / phosphate buffer, react at 2-4°C for 24 hours, after washing, the grafted amount of gelatin is 0.02nmol / cm 2 Then, in vitro mineralization was carried out, that is, it was soaked in 1.5 times the concentration of human simulated body fluid, soaked at 37 °C for 7 days, taken out and cleaned, to obtain nano inorganic calcium phosphate / biodegradable polylactic acid The composite oriented fiber membrane, wherein the content of low crystallinity calcium phosphate salt is 15....

Example Embodiment

[0027] Embodiment 2:

[0028] Polylactic acid is prepared by electrospinning to prepare a polylactic acid fiber film with a thickness of 75 μm, and a high-speed roller with a linear speed of 16.7 m / s is used to collect a polylactic acid oriented fiber film with a fiber orientation degree of more than 80%; the oriented fiber film is soaked In 2mg / mL gelatin / phosphate buffer, react at 2-4°C for 24 hours, after washing, the grafted amount of gelatin is 0.02nmol / cm 2 The polylactic acid oriented fibrous membrane; then mineralized in vitro, that is, immersed in 1.5 times the concentration of human simulated body fluid, soaked at 37 ° C for 7 days, taken out and cleaned to obtain nano-inorganic calcium phosphate / biodegradable polymer Lactic acid composite oriented fiber membrane, wherein the content of low-crystalline calcium phosphate salt is 15.1% (the preparation method of the polylactic acid composite oriented fiber membrane in this example is the same as that of Example 1).

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Abstract

The invention discloses a method for preparing composite material from inorganic calcium phosphate salt/biodegradable polymer fiber membrane. The method comprises the steps of superposing more than two inorganic calcium phosphate salt/biodegradable polymer fiber membranes to form a multilayer composite fiber membrane and hot press molding on the multilayer composite fiber membrane, wherein the orientation degree of fibers in the inorganic calcium phosphate salt/biodegradable polymer fiber membranes is more than 80 percent, and the included angle of the fiber orientation of adjacent layers of the multilayer composite fiber membrane is between 0 and 90 degrees. The method has the advantages of high adaptability, simple process, low cost and good repeatability. The prepared composite material has biological activity and remineralization performance, high mechanical properties and direction controllability.

Description

technical field [0001] The invention relates to a preparation method of a biodegradable composite material. Background technique [0002] Biodegradable composite materials are widely used in biomedical engineering fields such as medical implants, tissue repair and regeneration. Since it is difficult for a single material to meet the requirements of clinical mechanical and biological properties, the combination of different materials to obtain composite materials with special properties has become a research hotspot in current biomedical materials. Inorganic calcium phosphate / biodegradable polymer composites have good biodegradability and biocompatibility, and have been widely studied and applied in the field of bone tissue engineering. The use of new composite materials requires uniform distribution of inorganic particles in the composite system, good bonding force between inorganic particles and polymer substrates, high mechanical properties of composite materials, and the...

Claims

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Application Information

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IPC IPC(8): A61L27/46
Inventor 李孝红陈建刚崔文国冯波周绍兵
Owner SOUTHWEST JIAOTONG UNIV
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